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Structural and functional studies of enterovirus 2C proteins: promising targets for antiviral therapy.

Total Cost €


EC-Contrib. €






 EV-2C project word cloud

Explore the words cloud of the EV-2C project. It provides you a very rough idea of what is the project "EV-2C" about.

resistance    sepsis    3a    cell    basis    ssrna    sequence    seven    cycle    comprise    membranes    vivo    helicase    paralysis    homeostasis    replication    host    genomes    mutations    search    shed    responsible    array    2b    neonatal    resolution    interactions    drug    viruses    genome    characterise    cooperatively    enteroviral    hijack    pathogens    ex    lipid    aaa    rhinoviruses    ligand    membranous    positive    option    threatening    human    hexameric    disparate    microscopy    light    virus    enteroviruses    effect    electron    map    poliovirus    vaccination    requirement    molecular    inhibitor    cryo    encapsidation    coxsackieviruses    attractive    spectrum    vp1    conservation    serve    protein    diseases    template    2c    tomography    structural    d68    functional    organelles    morphogenesis    lifecycle    anti    virion    proteins    urgently    life    complexes    organisation    enterovirus    reorganisation    mild    2a    structurally    structure    alter    ranging    functions    sense    atpase    generate    situ    platforms    drugs    urgent    hundreds    encodes    ev    sought    a71    antivirals    viral    broad    cellular    genus   

Project "EV-2C" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 175˙572.00


 Project objective

The enterovirus (EV) genus comprises many important human pathogens including poliovirus, coxsackieviruses, EV-A71, EV-D68 and rhinoviruses. These viruses are responsible for a wide array of diseases ranging from mild to life-threatening, such as neonatal sepsis and paralysis. There are hundreds of enteroviruses, and vaccination to all of these is not a viable option. As such, there is an urgent requirement for effective broad-spectrum antivirals.

Enterovirus genomes comprise a positive-sense ssRNA genome which encodes four structural proteins (VP1--4) and seven non-structural proteins (2A--C, 3A--D). The non-structural proteins 2B, 2C and 3A cooperatively hijack host cell proteins and alter host cell membranes and lipid homeostasis to generate membranous replication organelles, which serve as platforms for genome replication and virion morphogenesis.

The 2C protein is a particularly attractive target for the development of antivirals due to its high level of sequence conservation. 2C is an AAA ATPase with many proposed functions within the virus lifecycle including helicase activity, reorganisation of cellular membranes and encapsidation. Several structurally disparate drugs target 2C on the basis that resistance mutations map to this protein; however, the molecular basis of their effect on 2C is not understood.

This project has two main objectives: 1. Determine the high-resolution structure of the functional hexameric 2C and inhibitor/ligand complexes by cryo-electron microscopy. 2. Use cryo-electron tomography to characterise the interactions 2C makes with viral and host proteins within ex-vivo and in situ replication organelles.

Understanding the organisation of 2C within replication organelles will shed new light on its role in the enterovirus life cycle, and the high-resolution structure of 2C will serve as a long sought-after search template for structure-based drug design of urgently-needed anti-enteroviral drugs.

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The information about "EV-2C" are provided by the European Opendata Portal: CORDIS opendata.

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