#	Pagina
attuale pagina	/open-h2020/projects/221722/index.html

Opendata, web and dolomites

OSTers SIGNED

Role of OligoSaccharyl Transferase enzymes in developmental signaling and congenital disorders of glycosylation

Total Cost €

EC-Contrib. €

Partnership

Views

OSTers project word cloud

Explore the words cloud of the OSTers project. It provides you a very rough idea of what is the project "OSTers" about.

manipulation insights defects cdgs function reticulum lacking vivo regulation broad deciphering proteins genetic transferase disorders glycosylation mutations asparagine precise therapeutic assembly components cdg oligosaccharyl final endoplasmic understand heterogeneity ost mechanisms glycans signaling animal phenotypic framework congenital patients clinical developmental occurs frameworks individual

Project "OSTers" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	183˙473 €
EC max contribution	183˙473 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-RI
Starting year	2019
Duration (year-month-day)	from 2019-06-01 to 2021-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	183˙473.00

Map

Project objective

Congenital disorders of glycosylation (CDGs) are genetic defects affecting the assembly and addition of asparagine (N)-glycans to proteins. N-glycosylation occurs in the endoplasmic reticulum by the Oligosaccharyl transferase (OST) complex. Mutations in components of OST complex are identified in CDG patients with broad clinical features. However, the mechanisms by which OST mutations cause phenotypic heterogeneity are not known. Moreover, in vivo studies on the precise role of individual OST components in animal development are lacking. In this framework, the goal of this proposal is to understand the function of OST complex during animal development, with a focus on their role in the regulation of developmental signaling pathways. The final aim will be to provide insights for deciphering some aspects of patients’ clinical features with OST mutations. This might lead to new frameworks for targeted therapeutic manipulation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "OSTERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "OSTERS" are provided by the European Opendata Portal: CORDIS opendata.