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MacrophInt SIGNED

Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MacrophInt project word cloud

Explore the words cloud of the MacrophInt project. It provides you a very rough idea of what is the project "MacrophInt" about.

pro    breast    knock    specimens    correlates    chronic    extracellular    mode    independent    exploring    cancers    elegant    mediated    immune    revealed    employ    migratory    sharp    subcellular    tam    extended    limit    human    reduces    surrounding    contexts    tumours    homeostasis    critical    synergize    strategy    amoeboid    paradigm    regulators    involve    cancer    inflammation    podosomes    tams    macrophage    complicate    ecm    morbidity    migration    anticancer    experiments    knockout    solid    unanticipated    macrophages    poor    function    blockade    lowers    death    disease    therapeutic    distinctive    largely    mesenchymal    tumour    reaching    implications    preserving    combat    recruitment    infiltration    combination    roles    primarily    requirement    adherence    matrix    simultaneously    healthy    insights    functions    integrin    models    signaling    utilize    endeavours    progression    mice    avenues    cells    mouse    proteolysis    stromal    contrast    halt    therapies    prognosis    manipulate    integrins   

Project "MacrophInt" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 116˙953 €
 EC max contribution 116˙953 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 116˙953.00

Map

 Project objective

Cancer is the most common cause of death and morbidity in Europe. New therapeutic targets to combat this disease are critical. Across many solid cancers, poor prognosis largely correlates with the infiltration of tumour-associated macrophages (TAMs). TAMs enhance tumour progression and complicate various anticancer therapies. Although macrophages primarily employ amoeboid migration for homeostasis and immune functions, TAMs primarily utilize mesenchymal migration. Experiments in mice revealed that blockade of TAM mesenchymal migration lowers infiltration within tumours and reduces tumour growth. Targeting this distinctive feature has the potential to limit TAM recruitment in tumours and halt disease progression, while preserving healthy macrophage functions. The mesenchymal migratory mode involves podosomes and is characterized by integrin-mediated adherence to the surrounding extracellular matrix (ECM), and the requirement of ECM proteolysis. In sharp contrast, amoeboid migration is independent of podosomes and integrins. We will investigate and evaluate the potential of targeting integrin signaling as a new strategy to manipulate TAM infiltration into tumours. Elegant knock-in and knockout mouse models will be used to establish the key regulators of integrin signaling in TAM mesenchymal migration. This novel paradigm will be extended to TAM migration in human breast tumour specimens. We will also provide new insights at the subcellular level by exploring the roles of integrin signaling in the formation and function of podosomes. Our study endeavours to identify novel and unanticipated avenues for blockade of TAM mesenchymal migration and tumour infiltration to synergize with current combination therapies that simultaneously target both pro-tumour stromal cells and cancer cells. Targeting mesenchymal migration in macrophages could have far-reaching implications beyond cancer in other disease contexts that involve macrophages including chronic inflammation.

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The information about "MACROPHINT" are provided by the European Opendata Portal: CORDIS opendata.

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