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MacrophInt SIGNED

Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MacrophInt project word cloud

Explore the words cloud of the MacrophInt project. It provides you a very rough idea of what is the project "MacrophInt" about.

correlates    healthy    integrin    limit    regulators    disease    combat    blockade    distinctive    lowers    sharp    ecm    tams    stromal    human    macrophage    chronic    critical    independent    simultaneously    subcellular    cancer    roles    cells    matrix    halt    pro    extended    homeostasis    therapeutic    mice    manipulate    prognosis    avenues    mesenchymal    anticancer    synergize    function    revealed    complicate    models    migration    proteolysis    experiments    elegant    functions    involve    reduces    requirement    preserving    knockout    cancers    knock    podosomes    breast    therapies    recruitment    solid    surrounding    paradigm    morbidity    contrast    largely    employ    insights    specimens    unanticipated    exploring    inflammation    mouse    combination    signaling    infiltration    endeavours    contexts    death    mode    utilize    tumours    integrins    tumour    mediated    primarily    amoeboid    tam    poor    implications    adherence    migratory    macrophages    extracellular    immune    strategy    progression    reaching   

Project "MacrophInt" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 116˙953 €
 EC max contribution 116˙953 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 116˙953.00

Map

 Project objective

Cancer is the most common cause of death and morbidity in Europe. New therapeutic targets to combat this disease are critical. Across many solid cancers, poor prognosis largely correlates with the infiltration of tumour-associated macrophages (TAMs). TAMs enhance tumour progression and complicate various anticancer therapies. Although macrophages primarily employ amoeboid migration for homeostasis and immune functions, TAMs primarily utilize mesenchymal migration. Experiments in mice revealed that blockade of TAM mesenchymal migration lowers infiltration within tumours and reduces tumour growth. Targeting this distinctive feature has the potential to limit TAM recruitment in tumours and halt disease progression, while preserving healthy macrophage functions. The mesenchymal migratory mode involves podosomes and is characterized by integrin-mediated adherence to the surrounding extracellular matrix (ECM), and the requirement of ECM proteolysis. In sharp contrast, amoeboid migration is independent of podosomes and integrins. We will investigate and evaluate the potential of targeting integrin signaling as a new strategy to manipulate TAM infiltration into tumours. Elegant knock-in and knockout mouse models will be used to establish the key regulators of integrin signaling in TAM mesenchymal migration. This novel paradigm will be extended to TAM migration in human breast tumour specimens. We will also provide new insights at the subcellular level by exploring the roles of integrin signaling in the formation and function of podosomes. Our study endeavours to identify novel and unanticipated avenues for blockade of TAM mesenchymal migration and tumour infiltration to synergize with current combination therapies that simultaneously target both pro-tumour stromal cells and cancer cells. Targeting mesenchymal migration in macrophages could have far-reaching implications beyond cancer in other disease contexts that involve macrophages including chronic inflammation.

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The information about "MACROPHINT" are provided by the European Opendata Portal: CORDIS opendata.

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