Opendata, web and dolomites

MetD-AO SIGNED

Methyl Donating artificial organelles to support liver cells in Non-alcoholic fatty liver disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MetD-AO project word cloud

Explore the words cloud of the MetD-AO project. It provides you a very rough idea of what is the project "MetD-AO" about.

organelles    functional    entirely    reaction    prior    successful    intracellular    copolymers    chemist    structurally    career    pharmaceutical    assemble    methacrylate    perform    assembly    hepatocytes    me    conduction    missing    hydrophilic    mimicking    acrylate    medical    science    stadler    latter    biocatalytic    prospects    tail    few    fatty    reactive    enzyme    compartment    nano    outcome    vitro    synthetase    methyl    intact    artificial    lysosomal    started    preserving    deficiencies    chronic    single    nonalcoholic    lost    lysosome    encompassing    donating    employing    expertise    self    spectrum    biology    amphiphilic    liver    therapeutic    disease    adenosylmethionine    multiple    cellular    characterization    nanoparticles    homeostasis    sized    carrier    poly    escape    dr    nafld    reported    polymer    colloidal    function    organic    metd    cytosol    membranolytic    biosynthesis    substitute    consisting    trained    host    oxygen    damage    protein    cell    respectively    western    release    complementary    gaining    failing    reactors    carboxypentyl    cholesterol    ao    encapsulated    cargo    world    destroyed    synth    aos   

Project "MetD-AO" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 219˙312.00

Map

 Project objective

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, encompassing a spectrum of liver damage. Multiple issues are involved on the cellular level in failing liver often including enzyme deficiencies such as reduced biosynthesis of S-adenosylmethionine (SAMe). Preserving SAMe homeostasis has only recently started to be considered as a potential therapeutic target in liver-related medical conditions. However, employing the required enzyme, SAMe synthetase (SAMe-synth), as a pharmaceutical, is challenging due to the general issues involved in intact (functional) protein delivery. The aim of the MetD-AO project is to assemble organic SAMe-synth activity mimicking polymer nanoparticles as artificial organelles (AO) and their in vitro characterization of intracellular function in hepatocytes. AOs are typically nano-sized single compartment reactors, aimed to perform a specific encapsulated biocatalytic reaction within a cell to substitute for missing or lost function. The AO will be based on amphiphilic copolymers consisting of a methyl-donating unit, cholesterol methacrylate and poly(5-carboxypentyl acrylate) as membranolytic hydrophilic tail. The latter two will aim at facilitating self-assembly and lysosomal escape, respectively. To allow structurally intact AO to escape the lysosome is unique since typically, the carrier is destroyed and only the therapeutic cargo is release into the cytosol. The proposed AOs with methyl-donating ability are highly advanced because the few prior reported AOs with intracellular activity all considered reactive oxygen related aspects at best. The successful outcome of MetD-AO has the potential to open up entirely new therapeutic opportunities in NAFLD. The complementary expertise of my host Dr. Stadler and me, a trained polymer chemist, will ensure a successful conduction of MetD-AO while it will enhance my future career prospects gaining experience in colloidal science and cell biology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "METD-AO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "METD-AO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

iRhomADAM (2020)

Uncovering the role of the iRhom2-ADAM17 interaction in inflammatory signalling

Read More