Opendata, web and dolomites

Prion Respiration SIGNED

The Role of Complex I Assembly Factors during Prion Diseases: Insights into Mitochondrial Neurobiology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Prion Respiration project word cloud

Explore the words cloud of the Prion Respiration project. It provides you a very rough idea of what is the project "Prion Respiration" about.

animal    interfering    aberrant    function    survival    syndrome    biology    functional    neurodegenerative    age    denoted    neurological    acad9    demonstrates    neurodegeneration    altered    broad    structure    prion    respiration    disorders    declines    neuronal    dysfunctions    mitochondrial    prions    helping    encoded    misassembly    energetic    oxidative    responsible    levels    drug    afs    cryo    identification    apoptosis    electron    disease    defects    diminish    diseases    parkinson    subsequently    strategies    mechanisms    exacerbated    biological    components    aging    mitochondria    cells    underlying    found    alzheimer    respiratory    assembly    proteins    decrease    childhood    structural    mutations    insights    characterization    lived    em    correct    energy    models    generate    chain    integrity    spectrum    cell    cellular    saxs    constitute    leigh    transport    stresses    dieseas    prevent    nuclear    complexes    neurons    ndufaf1    ecsit   

Project "Prion Respiration" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRENTO 

Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122
website: www.unitn.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 171˙473.00

Map

 Project objective

Mitochondria have a crucial role in cell survival and apoptosis, in particular in long-lived cells such as neurons. Mitochondria generate energetic potential through respiratory complexes I to IV, which constitute the electron transport chain. A number of studies demonstrates that mitochondrial integrity declines as a function of aging and dysfunctions may be exacerbated by age-related neurodegenerative diseases. Altered levels of complex I proteins have been found to be directly responsible for a decrease in energy production in Alzheimer’s and Parkinson's disease. Recently, a number of nuclear encoded mitochondrial proteins, denoted as “assembly factors” (AFs), have been identified as crucial components helping the complex I assembly. Defects in AFs (due to mutations or aberrant AFs processing) may cause complex I misassembly and mitochondrial dysfunctions leading to a broad spectrum of diseases, including neurological disorders in childhood-related dieseas as Leigh syndrome. The functional role of AFs during neurodegeneration has not been investigated yet. With the “Prion Respiration” project I propose to develop a research approach aimed at the identification of the biological role of three crucial complex I AFs (namely ECSIT, NDUFAF1 and ACAD9) in cellular and animal models using prion diseases as robust system to study neurodegenerative diseases. Subsequently, the role of prions in interfering the with the correct assembly of the AFs will be investigated using structural biology approaches, as SAXS and cryo-EM methods. The structural and functional characterization of key proteins involved in mitochondrial respiration will provide insights into the underlying mechanisms involved in neuronal function and may represent novel targets for structure-based drug design strategies to prevent or diminish the oxidative stresses underlying neurodegeneration.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRION RESPIRATION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRION RESPIRATION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ERA (2020)

Epigenetic Regulation in Acinetobacter baumannii

Read More  

WomInPubS (2019)

The modes and outcomes of interaction of (im) mobile Kurdish women with public space: a cross-cultural comparative study of different urban contexts

Read More  

PopulistFP (2019)

The Populist Politics of Foreign Policy

Read More