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LYSOKIN SIGNED

Architecture and regulation of PI3KC2β lipid kinase complex for nutrient signaling at the lysosome

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "LYSOKIN" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSVERBUND BERLIN EV 

Organization address
address: RUDOWER CHAUSSEE 17
city: BERLIN
postcode: 12489
website: www.fv-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-15   to  2022-04-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) coordinator 162˙806.00

Map

 Project objective

The lysosome is a eukaryotic organelle that coordinates degradative pathways with nutrient sensing and signalling. It therefore dictates cell growth and survival depending on nutrient availability. Dissecting the molecular machinery that enables these functions is of key importance to cell biology. The mTORC1 complex controls cell proliferation and metabolism by nutrient sensing at lysosomes and late endosomes (LyLEs). Recent work from the host revealed that during nutrient starvation, mTORC1 is repressed by the lipid PI(3,4)P2 at LyLEs which is produced by the class II phosphoinositide 3-kinase PI3KC2β. PI3KC2β is recruited to LyLEs via an interaction of its N-terminus with the Raptor subunit of mTORC1. The precise mechanisms of PI3KC2β regulation at LyLEs are unknown. Using a diverse suite of structural and biochemical methods, I propose to define how complex formation of PI3KC2β with mTORC1 and other LyLE associated proteins governs nutrient signaling and protein turnover at LyLEs. The proposed research may pave the way to combat diseases ranging from diabetes to cancer.

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The information about "LYSOKIN" are provided by the European Opendata Portal: CORDIS opendata.

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relatedResult rcn (865519) AGGIORNATO correttamente
lastchecktime (2022-09-28 16:49:30) correctly updated