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TARGLIO SIGNED

Improved glioblastoma treatment through targeted, local drug delivery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "TARGLIO" data sheet

The following table provides information about the project.

Coordinator
DOUBLE BOND PHARMACEUTICAL AB 

Organization address
address: VIRDINGS ALLE 32 B LTR
city: UPPSALA
postcode: 75450
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.doublebp.com/products/brain-cancer/
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DOUBLE BOND PHARMACEUTICAL AB SE (UPPSALA) coordinator 50˙000.00

Map

 Project objective

The aim of this project is to develop a business plan to guide clinical development and commercialisation of SI053; a novel gel formulation for the treatment of the most common and aggressive type of brain cancer called glioblastoma. Glioblastoma affects approximately 2-3 people in every 100,000 each year in Europe and has an extremely poor prognosis. 50% of patients die within a year and 90% die within three years. A combination of treatments are used to treat patients but are limited in their efficacy due to the physical location of the tumour and the aggressiveness of the condition. Double Bond has developed SI053, a unique polymer matrix that contains temozolomide to locally treat brain tumours without harming healthy tissue. Temozolomide is a first line, highly potent chemotherapeutic. When administered systemically, it is highly toxic to healthy tissue and its final concentration is significantlly reduced since it has to cross the blood brain barrier. Also, it cannot be administered right after surgery, delaying chemotherapy by a few weeks. Double Bond’s drug delivery platform allows a high concentration of temozolomide to be released slowly and directly to the tumour right after surgery. Research to date on SI053’s use as a treatment for glioblastoma has been highly promising. Double Bond now aims to clinically validate SI053 in a clinical trial, demonstrating proof of concept. The current proposed Phase 1 project will facilitate in the development process and help define clinical and business strategies. SME Instrument funding will allow SI053 to take a substantial step along the path of commercialisation.

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The information about "TARGLIO" are provided by the European Opendata Portal: CORDIS opendata.

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