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ENTRAIN SIGNED

ENdoThelial macRophage Alliance In Neuroinflammation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ENTRAIN project word cloud

Explore the words cloud of the ENTRAIN project. It provides you a very rough idea of what is the project "ENTRAIN" about.

morphological    mutual    deux    pas    closely    frequently    sclerosis    chemoproteomics    contact    gap    suffering    cell    discoveries    cerebral    endothelial    rarefaction    disease    inflammatory    burden    function    barrier    occurring    treatment    brain    interactions    pathology    talk    cross    annual    de    mechanisms    intricate    cutting    functional    viral    macrophages    europeans    populations    cells    neurological    technologies    huge    foundation    imaging    stroke    lay    building    million    intimate    cns    resolution    molecular    relationship    intravital    vascular    disabling    care    disentangling    amount    group    economic    euros    blocks    understand    players    flow    cellular    blood    translational    almost    ms    vessels    multiple    billion    characterising    treatments    enormous    400    neuroinflammation    impaired    macrophage    entrain    entities    indicate    therapies    alzheimer    genetic    rare    bbb    mode    patient    regarding    neuroscience    interact    edge    diseases    ad    tools   

Project "ENTRAIN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET zu LUEBECK 

Organization address
address: RATZEBURGER ALLEE 160
city: LUBECK
postcode: 23562
website: http://www.uni-luebeck.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙664˙173 €
 EC max contribution 3˙664˙173 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET zu LUEBECK DE (LUBECK) coordinator 505˙576.00
2    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 281˙276.00
3    UNIVERSITAET BERN CH (BERN) participant 281˙276.00
4    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 280˙805.00
5    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 274˙802.00
6    MIMETAS BV NL (Leiden) participant 265˙619.00
7    STICHTING VUMC NL (AMSTERDAM) participant 265˙619.00
8    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI IT (MILANO) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI BRESCIA IT (BRESCIA) participant 261˙499.00
10    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 252˙788.00
11    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 252˙788.00
12    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 250˙904.00
13    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) participant 229˙715.00
14    BOEHRINGER INGELHEIM PHARMA GMBH &CO KG DE (INGELHEIM) partner 0.00
15    BRENDINN THERAPEUTICS B.V. NL (HEEMSKERK) partner 0.00
16    Dualsystems Biotech AG CH (Zurich-Schlieren) partner 0.00
17    Incontinentia Pigmenti France FR (saint didier au mont d'or) partner 0.00
18    POLYGENE AG CH (RÜMLANG) partner 0.00
19    STROKE ALLIANCE FOR EUROPE BE (BRUSSELS) partner 0.00
20    UNIVERSITEIT LEIDEN NL (LEIDEN) partner 0.00

Map

 Project objective

Neurological diseases cause enormous suffering and a great economic burden. Almost 20 million Europeans are affected by the most frequently occurring and disabling disease entities, such as stroke, Alzheimer’s disease (AD), or multiple sclerosis (MS), and these numbers do not include the large group of rare diseases that affect the CNS. Overall, the annual costs for patient care amount to 400 billion Euros. Common features of many neurological diseases are a vascular pathology with impaired blood-brain barrier (BBB) function or with reduced blood flow and inflammatory changes. As the two are often associated, disentangling their intricate and mutual relationship is a major task for translational neuroscience that could improve the treatment of many neurological diseases. At the cellular level, key players are brain endothelial cells as the building blocks of cerebral vessels and macrophages as the main inflammatory cells of the brain. Recent discoveries indicate that endothelial cells and brain macrophages are in intimate contact and closely interact. However, there is a huge gap of knowledge regarding the specific mode and the consequences of these interactions. Therefore, in-depth analyses of the molecular mechanisms involved are essential to identify and understand key features of macrophage-endothelial cross-talk, and exploitation of this information for the development of treatments of neurological diseases. ENTRAIN will undertake this task, using novel and emerging technologies, such as cutting-edge chemoproteomics, unique genetic and viral tools for targeting of defined cell populations, and high resolution intravital imaging. By characterising the pas de deux of endothelial cells and macrophages at the functional and morphological level, we will lay the foundation for better therapies for neurological diseases. The results will impact on the understanding of neuroinflammation, but also on the rarefaction of vessels.

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The information about "ENTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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