Explore the words cloud of the ENTRAIN project. It provides you a very rough idea of what is the project "ENTRAIN" about.
The following table provides information about the project.
UNIVERSITAET zu LUEBECK
|Coordinator Country||Germany [DE]|
|Total cost||3˙664˙173 €|
|EC max contribution||3˙664˙173 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2019-05-01 to 2023-04-30|
Take a look of project's partnership.
|1||UNIVERSITAET zu LUEBECK||DE (LUBECK)||coordinator||505˙576.00|
|2||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||participant||281˙276.00|
|3||UNIVERSITAET BERN||CH (BERN)||participant||281˙276.00|
|4||HELSINGIN YLIOPISTO||FI (HELSINGIN YLIOPISTO)||participant||280˙805.00|
|5||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||participant||274˙802.00|
|6||MIMETAS BV||NL (Leiden)||participant||265˙619.00|
|7||STICHTING VUMC||NL (AMSTERDAM)||participant||265˙619.00|
|8||ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI||IT (MILANO)||participant||261˙499.00|
|9||UNIVERSITA DEGLI STUDI DI BRESCIA||IT (BRESCIA)||participant||261˙499.00|
|10||UNIVERSITAETSKLINIKUM FREIBURG||DE (FREIBURG)||participant||252˙788.00|
|11||WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER||DE (MUENSTER)||participant||252˙788.00|
|12||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||participant||250˙904.00|
|13||INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES||HU (Budapest)||participant||229˙715.00|
|14||BOEHRINGER INGELHEIM PHARMA GMBH &CO KG||DE (INGELHEIM)||partner||0.00|
|15||BRENDINN THERAPEUTICS B.V.||NL (HEEMSKERK)||partner||0.00|
|16||Dualsystems Biotech AG||CH (Zurich-Schlieren)||partner||0.00|
|17||Incontinentia Pigmenti France||FR (saint didier au mont d'or)||partner||0.00|
|18||POLYGENE AG||CH (RÜMLANG)||partner||0.00|
|19||STROKE ALLIANCE FOR EUROPE||BE (BRUSSELS)||partner||0.00|
|20||UNIVERSITEIT LEIDEN||NL (LEIDEN)||partner||0.00|
Neurological diseases cause enormous suffering and a great economic burden. Almost 20 million Europeans are affected by the most frequently occurring and disabling disease entities, such as stroke, Alzheimer’s disease (AD), or multiple sclerosis (MS), and these numbers do not include the large group of rare diseases that affect the CNS. Overall, the annual costs for patient care amount to 400 billion Euros. Common features of many neurological diseases are a vascular pathology with impaired blood-brain barrier (BBB) function or with reduced blood flow and inflammatory changes. As the two are often associated, disentangling their intricate and mutual relationship is a major task for translational neuroscience that could improve the treatment of many neurological diseases. At the cellular level, key players are brain endothelial cells as the building blocks of cerebral vessels and macrophages as the main inflammatory cells of the brain. Recent discoveries indicate that endothelial cells and brain macrophages are in intimate contact and closely interact. However, there is a huge gap of knowledge regarding the specific mode and the consequences of these interactions. Therefore, in-depth analyses of the molecular mechanisms involved are essential to identify and understand key features of macrophage-endothelial cross-talk, and exploitation of this information for the development of treatments of neurological diseases. ENTRAIN will undertake this task, using novel and emerging technologies, such as cutting-edge chemoproteomics, unique genetic and viral tools for targeting of defined cell populations, and high resolution intravital imaging. By characterising the pas de deux of endothelial cells and macrophages at the functional and morphological level, we will lay the foundation for better therapies for neurological diseases. The results will impact on the understanding of neuroinflammation, but also on the rarefaction of vessels.
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The information about "ENTRAIN" are provided by the European Opendata Portal: CORDIS opendata.
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