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Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies

Total Cost €


EC-Contrib. €






 NEUMACS project word cloud

Explore the words cloud of the NEUMACS project. It provides you a very rough idea of what is the project "NEUMACS" about.

models    coordinated    requiring    neuropathy    lacking    cord    representing    brain    vital    supportive    hypothesis    expressing    guaranteed    ingested    contributors    severe    despite    integration    exponentially    animal    protect    limited    resident    transcriptome    line    wall    global    ens    insights    ageing    neuron    mf    21st    luminal    treatment    contents    ground    depletion    motility    vomiting    gut    dysfunction    digest    obesity    equipped    first    therapeutic    century    nervous    unravel    thereto    population    food    disorders    breaking    secretion    diabetes    mechanisms    absorption    function    independently    neurons    neuroprotective    spinal    impacts    closely    tract    subpopulation    vascularization    pose    ing    incidence    chronic    significantly    constipation    collected    gastrointestinal    burden    stasis    apoptosis    enteric    provocative    malabsorption    absorb    patients    subsequently    macrophages    impaired    input    bloating    na    survival    distress    severely    pain    continuous    neuropathies    neural    prevalent    health   

Project "NEUMACS" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙500˙000.00


 Project objective

The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function independently of input from brain or spinal cord. Reduction in number or dysfunction of the neurons within the gut wall, also referred to as enteric neuropathy, significantly impacts on gut function, resulting in stasis of luminal contents and malabsorption, chronic pain, vomiting, bloating and severe constipation. Enteric neuropathies are common in prevalent disorders such as obesity, diabetes, and ageing, all major contributors to the health burden. Despite the continuous global increase in incidence of these disorders, the insight in the mechanisms leading to the reduction or dysfunction of enteric neurons is limited and most importantly, adequate treatment is lacking. Recently, we collected evidence that survival of enteric neurons is guaranteed by a unique subpopulation of resident macrophages closely associated to the ENS and expressing a typical neuroprotective / -supportive transcriptome. In line, depletion of these neuron-associated macrophages (NA-MF) results in apoptosis and a reduction in number of enteric neurons leading to severely impaired gastrointestinal motility. We pose the provocative hypothesis that enteric neuropathy results from impaired support to the ENS by NA-MF, leading to neural distress and apoptosis. Using state-of-the-art methods, we will first characterize in depth the NA-MF population to subsequently unravel the mechanisms leading to failure of NA-MF to support and protect the ENS in animal models and in patients. These ground-breaking insights will allow us to identify therapeutic targets for the treatment of enteric neuropathies, representing an exponentially growing health problem of the 21st century.

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