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NEUMACS SIGNED

Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEUMACS project word cloud

Explore the words cloud of the NEUMACS project. It provides you a very rough idea of what is the project "NEUMACS" about.

health    transcriptome    insights    enteric    mf    secretion    supportive    independently    line    collected    depletion    unravel    spinal    constipation    subpopulation    malabsorption    neuroprotective    therapeutic    coordinated    models    requiring    subsequently    ens    dysfunction    neural    treatment    macrophages    global    gut    closely    expressing    diabetes    lacking    breaking    cord    input    mechanisms    luminal    patients    severe    stasis    chronic    representing    disorders    digest    first    ground    distress    resident    absorb    food    protect    gastrointestinal    neuron    contents    pain    exponentially    equipped    significantly    absorption    limited    survival    despite    apoptosis    impaired    animal    vascularization    21st    impacts    continuous    vomiting    function    neurons    ing    contributors    burden    tract    hypothesis    provocative    prevalent    thereto    pose    integration    population    neuropathies    severely    incidence    bloating    ingested    wall    guaranteed    century    ageing    na    brain    nervous    neuropathy    motility    vital    obesity   

Project "NEUMACS" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙500˙000.00

Map

 Project objective

The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function independently of input from brain or spinal cord. Reduction in number or dysfunction of the neurons within the gut wall, also referred to as enteric neuropathy, significantly impacts on gut function, resulting in stasis of luminal contents and malabsorption, chronic pain, vomiting, bloating and severe constipation. Enteric neuropathies are common in prevalent disorders such as obesity, diabetes, and ageing, all major contributors to the health burden. Despite the continuous global increase in incidence of these disorders, the insight in the mechanisms leading to the reduction or dysfunction of enteric neurons is limited and most importantly, adequate treatment is lacking. Recently, we collected evidence that survival of enteric neurons is guaranteed by a unique subpopulation of resident macrophages closely associated to the ENS and expressing a typical neuroprotective / -supportive transcriptome. In line, depletion of these neuron-associated macrophages (NA-MF) results in apoptosis and a reduction in number of enteric neurons leading to severely impaired gastrointestinal motility. We pose the provocative hypothesis that enteric neuropathy results from impaired support to the ENS by NA-MF, leading to neural distress and apoptosis. Using state-of-the-art methods, we will first characterize in depth the NA-MF population to subsequently unravel the mechanisms leading to failure of NA-MF to support and protect the ENS in animal models and in patients. These ground-breaking insights will allow us to identify therapeutic targets for the treatment of enteric neuropathies, representing an exponentially growing health problem of the 21st century.

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The information about "NEUMACS" are provided by the European Opendata Portal: CORDIS opendata.

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