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NEUMACS SIGNED

Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEUMACS project word cloud

Explore the words cloud of the NEUMACS project. It provides you a very rough idea of what is the project "NEUMACS" about.

patients    treatment    first    distress    pain    thereto    secretion    mechanisms    spinal    diabetes    function    requiring    impaired    pose    neuropathies    neural    absorption    resident    hypothesis    models    neurons    constipation    cord    survival    neuroprotective    breaking    continuous    disorders    subsequently    chronic    incidence    prevalent    line    food    bloating    provocative    ageing    motility    brain    gut    insights    luminal    mf    expressing    protect    absorb    animal    exponentially    ground    obesity    population    malabsorption    macrophages    significantly    contributors    equipped    transcriptome    collected    century    impacts    neuron    na    guaranteed    supportive    representing    lacking    wall    21st    severely    global    independently    apoptosis    ingested    vital    neuropathy    severe    ens    dysfunction    burden    subpopulation    tract    enteric    input    closely    vascularization    therapeutic    unravel    digest    stasis    contents    health    gastrointestinal    vomiting    coordinated    depletion    nervous    integration    ing    limited    despite   

Project "NEUMACS" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙500˙000.00

Map

 Project objective

The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function independently of input from brain or spinal cord. Reduction in number or dysfunction of the neurons within the gut wall, also referred to as enteric neuropathy, significantly impacts on gut function, resulting in stasis of luminal contents and malabsorption, chronic pain, vomiting, bloating and severe constipation. Enteric neuropathies are common in prevalent disorders such as obesity, diabetes, and ageing, all major contributors to the health burden. Despite the continuous global increase in incidence of these disorders, the insight in the mechanisms leading to the reduction or dysfunction of enteric neurons is limited and most importantly, adequate treatment is lacking. Recently, we collected evidence that survival of enteric neurons is guaranteed by a unique subpopulation of resident macrophages closely associated to the ENS and expressing a typical neuroprotective / -supportive transcriptome. In line, depletion of these neuron-associated macrophages (NA-MF) results in apoptosis and a reduction in number of enteric neurons leading to severely impaired gastrointestinal motility. We pose the provocative hypothesis that enteric neuropathy results from impaired support to the ENS by NA-MF, leading to neural distress and apoptosis. Using state-of-the-art methods, we will first characterize in depth the NA-MF population to subsequently unravel the mechanisms leading to failure of NA-MF to support and protect the ENS in animal models and in patients. These ground-breaking insights will allow us to identify therapeutic targets for the treatment of enteric neuropathies, representing an exponentially growing health problem of the 21st century.

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