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NEUMACS SIGNED

Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NEUMACS project word cloud

Explore the words cloud of the NEUMACS project. It provides you a very rough idea of what is the project "NEUMACS" about.

malabsorption    dysfunction    guaranteed    neural    luminal    coordinated    population    expressing    absorb    impacts    enteric    incidence    mf    integration    protect    diabetes    vomiting    thereto    survival    disorders    wall    tract    neuroprotective    treatment    depletion    century    21st    motility    absorption    stasis    line    equipped    global    significantly    secretion    input    patients    exponentially    severe    hypothesis    obesity    severely    representing    brain    digest    closely    health    ground    gut    therapeutic    lacking    subpopulation    constipation    first    resident    continuous    na    gastrointestinal    vital    collected    provocative    impaired    contributors    pain    ingested    despite    transcriptome    unravel    supportive    mechanisms    neuropathies    macrophages    subsequently    requiring    spinal    prevalent    pose    animal    ageing    vascularization    ing    limited    neurons    function    chronic    cord    ens    neuropathy    contents    insights    apoptosis    breaking    nervous    models    burden    bloating    distress    independently    neuron    food   

Project "NEUMACS" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙500˙000.00

Map

 Project objective

The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function independently of input from brain or spinal cord. Reduction in number or dysfunction of the neurons within the gut wall, also referred to as enteric neuropathy, significantly impacts on gut function, resulting in stasis of luminal contents and malabsorption, chronic pain, vomiting, bloating and severe constipation. Enteric neuropathies are common in prevalent disorders such as obesity, diabetes, and ageing, all major contributors to the health burden. Despite the continuous global increase in incidence of these disorders, the insight in the mechanisms leading to the reduction or dysfunction of enteric neurons is limited and most importantly, adequate treatment is lacking. Recently, we collected evidence that survival of enteric neurons is guaranteed by a unique subpopulation of resident macrophages closely associated to the ENS and expressing a typical neuroprotective / -supportive transcriptome. In line, depletion of these neuron-associated macrophages (NA-MF) results in apoptosis and a reduction in number of enteric neurons leading to severely impaired gastrointestinal motility. We pose the provocative hypothesis that enteric neuropathy results from impaired support to the ENS by NA-MF, leading to neural distress and apoptosis. Using state-of-the-art methods, we will first characterize in depth the NA-MF population to subsequently unravel the mechanisms leading to failure of NA-MF to support and protect the ENS in animal models and in patients. These ground-breaking insights will allow us to identify therapeutic targets for the treatment of enteric neuropathies, representing an exponentially growing health problem of the 21st century.

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The information about "NEUMACS" are provided by the European Opendata Portal: CORDIS opendata.

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