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Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies

Total Cost €


EC-Contrib. €






 NEUMACS project word cloud

Explore the words cloud of the NEUMACS project. It provides you a very rough idea of what is the project "NEUMACS" about.

disorders    therapeutic    constipation    macrophages    severe    distress    animal    ground    stasis    transcriptome    protect    apoptosis    absorb    coordinated    mf    requiring    luminal    wall    dysfunction    neuroprotective    unravel    severely    century    expressing    contents    food    neurons    collected    provocative    mechanisms    secretion    na    integration    equipped    impaired    depletion    representing    patients    motility    neuropathies    absorption    contributors    treatment    vital    pain    limited    closely    subsequently    pose    neuropathy    gut    cord    ens    prevalent    line    nervous    breaking    burden    insights    resident    independently    global    population    exponentially    ing    incidence    input    neuron    bloating    survival    despite    spinal    tract    21st    hypothesis    chronic    significantly    neural    thereto    lacking    vascularization    vomiting    gastrointestinal    function    obesity    health    ageing    impacts    models    ingested    continuous    first    supportive    digest    malabsorption    guaranteed    enteric    diabetes    brain    subpopulation   

Project "NEUMACS" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙500˙000.00


 Project objective

The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function independently of input from brain or spinal cord. Reduction in number or dysfunction of the neurons within the gut wall, also referred to as enteric neuropathy, significantly impacts on gut function, resulting in stasis of luminal contents and malabsorption, chronic pain, vomiting, bloating and severe constipation. Enteric neuropathies are common in prevalent disorders such as obesity, diabetes, and ageing, all major contributors to the health burden. Despite the continuous global increase in incidence of these disorders, the insight in the mechanisms leading to the reduction or dysfunction of enteric neurons is limited and most importantly, adequate treatment is lacking. Recently, we collected evidence that survival of enteric neurons is guaranteed by a unique subpopulation of resident macrophages closely associated to the ENS and expressing a typical neuroprotective / -supportive transcriptome. In line, depletion of these neuron-associated macrophages (NA-MF) results in apoptosis and a reduction in number of enteric neurons leading to severely impaired gastrointestinal motility. We pose the provocative hypothesis that enteric neuropathy results from impaired support to the ENS by NA-MF, leading to neural distress and apoptosis. Using state-of-the-art methods, we will first characterize in depth the NA-MF population to subsequently unravel the mechanisms leading to failure of NA-MF to support and protect the ENS in animal models and in patients. These ground-breaking insights will allow us to identify therapeutic targets for the treatment of enteric neuropathies, representing an exponentially growing health problem of the 21st century.

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