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ProTeCT SIGNED

Proteasome as a target to combat trichomoniasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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Project "ProTeCT" data sheet

The following table provides information about the project.

Coordinator
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. 

Organization address
address: FLEMINGOVO NAM. 542/2
city: PRAHA 6
postcode: 16610
website: www.uochb.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 237˙756 €
 EC max contribution 237˙756 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2022-11-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. CZ (PRAHA 6) coordinator 237˙756.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

Trichomoniasis, caused by the protozoan parasite Trichomonas spp., is the most common, non-viral, sexually transmitted infection in the world. Only two closely related antibiotic drugs are approved for its treatment. The accelerating emergence of resistance to current antibiotics and no alternative treatment options pose an increasing threat to public health, resulting in an urgent need for novel effective anti-parasitic compounds. This project focuses on Trichomonas proteasome that is an underexploited enzyme critical for parasite survival. In this proposal, the proteasome will be functionally and structurally characterized. The substrate specificity of each subunit will be determined and fluorescent substrates that can monitor activity of each subunit will be designed. Libraries of proteasome inhibitors will be screened and hit compounds will be analyzed in co-crystallization studies with Tv proteasome. Ultimately, biochemical and structural data will be used to rationally design inhibitors for treatment of trichomoniasis.

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The information about "PROTECT" are provided by the European Opendata Portal: CORDIS opendata.

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