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Boosting Ethionamide efficacy and lowering the dose with a small molecule transcriptional modulators, to overcoming MDR-TB infections and define a new place for Ethionamide in 1st-line TB treatments.

Total Cost €


EC-Contrib. €






 TRIC-TB project word cloud

Explore the words cloud of the TRIC-TB project. It provides you a very rough idea of what is the project "TRIC-TB" about.

time    mtb    treatment    gsk038    leads    optimization    eth    exploration    proven    once    bioversys    mdr    independently    regimen    placement    benefit    clinically    million    infectious    active    action    scientific    outcomes    xdr    lille    status    patient    mycobacterium    dosing    list    starting    transcriptional    pd    clinical    resistance    communities    rates    relapse       2016    medicines    ethionamide    collaborators    compound    again    synergistic    kill    gsk098    lower    vital    boosted    extensively    line    480    resistant    compounds    drug    glaxosmithkline    2nd    human    70    safety    suffers    people    tuberculosis    percent    bvl    boost    extensive    sensitive    restore    previously    reported    vivo    multidrug    vitro    mechanism    acting    strains    therapeutic    pk    first    universal    modulators    world    significantly    levels    mortality    class    killed    ind    proprietary    infection    ultimately    cure    therapy    tb    doses    overcoming    disease    combinations    university   

Project "TRIC-TB" data sheet

The following table provides information about the project.


Organization address
city: BASEL
postcode: 4057

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 8˙373˙250 €
 EC max contribution 6˙926˙375 € (83%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2018-16-single-stage
 Funding Scheme IMI2-RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOVERSYS AG CH (BASEL) coordinator 6˙926˙375.00


 Project objective

Tuberculosis (TB) is the world’s leading infectious disease. It killed 1.7 million people in 2016 and 10.4 million people developed active TB in the same year. In 2016, 480’000 of TB cases were multidrug-resistant (MDR-TB) and 9% percent of those cases are extensively drug-resistant (XDR), with mortality rates as high as 70%. Ethionamide (ETH) is a vital part of the WHO essential medicines list of 2nd-line TB therapy for MDR-TB, however, ETH suffers from significant levels of resistance and side effects at current dosing levels. BVL-GSK038 and BVL-GSK098 are proprietary to BioVersys/GlaxoSmithKline and have been developed through an extensive Lead Optimization program with collaborators from Lille University. Low doses of both compounds fully restore and “boost” the activity of ETH to rapidly kill Mycobacterium tuberculosis (Mtb) including MDR strains at significantly lower doses of ETH than previously reported, thus making MDR-TB sensitive to ETH once again. Through a comprehensive IND enabling package including in vitro and in vivo assessment of ETH with BVL-GSK038 and BVL-GSK098, including PK/PD, resistance development, safety, mechanism of action and synergistic studies with different drug compound combinations and then first in human clinical studies the consortium aims to:

i) Define the future placement of a boosted ETH (ETH BVL-GSK038 or BVL-GSK098) in a universal TB treatment regimen, including overcoming MDR-TB with improved safety, time to cure and relapse rates;

Ultimately, we expect to identify a new and clinically proven TB regimen that leads to better patient outcomes independently of the starting resistance status of the TB infection. The TB and wider scientific communities will benefit from an improved understanding of ETH and the exploration of a novel class of therapeutic compounds acting on transcriptional modulators (BVL-GSK038 and BVL-GSK098).

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The information about "TRIC-TB" are provided by the European Opendata Portal: CORDIS opendata.

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