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HITSCIL SIGNED

How intraflagellar transport shapes the cilium: a single-molecule systems study

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HITSCIL project word cloud

Explore the words cloud of the HITSCIL project. It provides you a very rough idea of what is the project "HITSCIL" about.

fluorescence    light    directional    animal    indicated    vice    molecule    organelles    probes    cilia    consist    dynamics    zoom    tools    disturbances    sensors    proteins    animals    elegans    position    organelle    shed    perspective    unprecedented    perturbations    lab    substantially    toolbox    structure    fundamental    external    intraflagellar    solutions    eukaryotic    cells    specialized    microscopy    repellent    membrane    environment    chemotaxis    preliminary    motor    transport    driving    experiments    soluble    versa    exposure    visualize    nbsp    laboratory    sensing    length    water    quantitative    dynamically    shown    ciliary    chemosensory    critically    fluorescent    enveloped    living    antennas    functions    fascinating    maintenance    microtubule    axoneme    sense    signalling    instrumentation    place    relationship    push    sensory    single    quantify    mechanism    cooperation    function    microtubules    intracellular    understand    regulated    molecules    axonemal    connection    ift   

Project "HITSCIL" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙499˙580 €
 EC max contribution 2˙499˙580 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 2˙499˙580.00

Map

 Project objective

Sensory cilia are organelles extending like antennas from many eukaryotic cells, with crucial functions in sensing and signalling. Cilia consist of an axoneme built of microtubules, enveloped by a specialized membrane. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). In my laboratory, we study the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environment for chemotaxis. Over the past years, we have developed a unique set of quantitative, single-molecule fluorescence microscopy tools that allow us to visualize and quantify IFT dynamics with unprecedented detail in living animals. So far, our focus has been on the cooperation of the motor proteins driving IFT. The overall objective of my current proposal is to zoom out and shed light on the connection between ciliary structure, chemosensory function and IFT, from a systems perspective. Recent work has indicated that axoneme length is controlled by IFT. Preliminary results from my laboratory show that axoneme length changes dynamically in response to perturbations of IFT or cilia. Furthermore, we have shown that IFT is substantially affected upon exposure of animals to known repellent solutions. The four major aims in my proposal are to: • determine how directional changes in IFT are regulated and are affected by external disturbances, • understand the dynamics of the axonemal microtubules and how IFT affects these dynamics and vice versa, • study how sensory ciliary function affects IFT and ciliary structure, • further develop our (single-molecule) fluorescence microscopy toolbox by improving instrumentation and using better fluorescent probes and sensors. These experiments will place my lab in a unique position to push forward our understanding of the relationship between structure, function and dynamics of transport of this fascinating and fundamental organelle.

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The information about "HITSCIL" are provided by the European Opendata Portal: CORDIS opendata.

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