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HITSCIL SIGNED

How intraflagellar transport shapes the cilium: a single-molecule systems study

Total Cost €

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EC-Contrib. €

0

Partnership

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 HITSCIL project word cloud

Explore the words cloud of the HITSCIL project. It provides you a very rough idea of what is the project "HITSCIL" about.

cells    experiments    sensors    driving    exposure    indicated    sensory    living    lab    molecule    elegans    consist    axonemal    specialized    maintenance    probes    structure    quantitative    cooperation    tools    mechanism    eukaryotic    solutions    light    chemotaxis    nbsp    axoneme    cilia    preliminary    shown    motor    functions    substantially    position    ift    proteins    shed    water    chemosensory    repellent    intracellular    ciliary    environment    vice    fluorescent    organelles    unprecedented    place    visualize    disturbances    enveloped    organelle    microscopy    transport    fascinating    zoom    intraflagellar    perspective    laboratory    regulated    sense    connection    instrumentation    sensing    directional    fundamental    quantify    push    microtubule    dynamics    relationship    antennas    perturbations    understand    single    function    toolbox    soluble    membrane    external    microtubules    critically    molecules    animal    signalling    dynamically    length    fluorescence    versa    animals   

Project "HITSCIL" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙499˙580 €
 EC max contribution 2˙499˙580 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 2˙499˙580.00

Map

 Project objective

Sensory cilia are organelles extending like antennas from many eukaryotic cells, with crucial functions in sensing and signalling. Cilia consist of an axoneme built of microtubules, enveloped by a specialized membrane. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). In my laboratory, we study the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environment for chemotaxis. Over the past years, we have developed a unique set of quantitative, single-molecule fluorescence microscopy tools that allow us to visualize and quantify IFT dynamics with unprecedented detail in living animals. So far, our focus has been on the cooperation of the motor proteins driving IFT. The overall objective of my current proposal is to zoom out and shed light on the connection between ciliary structure, chemosensory function and IFT, from a systems perspective. Recent work has indicated that axoneme length is controlled by IFT. Preliminary results from my laboratory show that axoneme length changes dynamically in response to perturbations of IFT or cilia. Furthermore, we have shown that IFT is substantially affected upon exposure of animals to known repellent solutions. The four major aims in my proposal are to: • determine how directional changes in IFT are regulated and are affected by external disturbances, • understand the dynamics of the axonemal microtubules and how IFT affects these dynamics and vice versa, • study how sensory ciliary function affects IFT and ciliary structure, • further develop our (single-molecule) fluorescence microscopy toolbox by improving instrumentation and using better fluorescent probes and sensors. These experiments will place my lab in a unique position to push forward our understanding of the relationship between structure, function and dynamics of transport of this fascinating and fundamental organelle.

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The information about "HITSCIL" are provided by the European Opendata Portal: CORDIS opendata.

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