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HITSCIL SIGNED

How intraflagellar transport shapes the cilium: a single-molecule systems study

Total Cost €

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EC-Contrib. €

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Partnership

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 HITSCIL project word cloud

Explore the words cloud of the HITSCIL project. It provides you a very rough idea of what is the project "HITSCIL" about.

push    substantially    cilia    water    environment    microtubules    exposure    axoneme    sensors    ciliary    length    dynamics    microtubule    sense    regulated    eukaryotic    indicated    structure    unprecedented    shed    molecule    toolbox    animal    understand    axonemal    versa    sensory    chemotaxis    dynamically    enveloped    consist    laboratory    lab    membrane    intraflagellar    driving    place    preliminary    signalling    molecules    organelle    cooperation    experiments    animals    elegans    soluble    quantify    visualize    connection    organelles    vice    cells    mechanism    shown    functions    solutions    single    microscopy    tools    specialized    perturbations    fundamental    instrumentation    position    zoom    critically    antennas    nbsp    perspective    function    maintenance    proteins    sensing    repellent    external    intracellular    living    relationship    probes    transport    quantitative    fascinating    chemosensory    disturbances    directional    light    fluorescence    fluorescent    ift    motor   

Project "HITSCIL" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙499˙580 €
 EC max contribution 2˙499˙580 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 2˙499˙580.00

Map

 Project objective

Sensory cilia are organelles extending like antennas from many eukaryotic cells, with crucial functions in sensing and signalling. Cilia consist of an axoneme built of microtubules, enveloped by a specialized membrane. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). In my laboratory, we study the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environment for chemotaxis. Over the past years, we have developed a unique set of quantitative, single-molecule fluorescence microscopy tools that allow us to visualize and quantify IFT dynamics with unprecedented detail in living animals. So far, our focus has been on the cooperation of the motor proteins driving IFT. The overall objective of my current proposal is to zoom out and shed light on the connection between ciliary structure, chemosensory function and IFT, from a systems perspective. Recent work has indicated that axoneme length is controlled by IFT. Preliminary results from my laboratory show that axoneme length changes dynamically in response to perturbations of IFT or cilia. Furthermore, we have shown that IFT is substantially affected upon exposure of animals to known repellent solutions. The four major aims in my proposal are to: • determine how directional changes in IFT are regulated and are affected by external disturbances, • understand the dynamics of the axonemal microtubules and how IFT affects these dynamics and vice versa, • study how sensory ciliary function affects IFT and ciliary structure, • further develop our (single-molecule) fluorescence microscopy toolbox by improving instrumentation and using better fluorescent probes and sensors. These experiments will place my lab in a unique position to push forward our understanding of the relationship between structure, function and dynamics of transport of this fascinating and fundamental organelle.

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The information about "HITSCIL" are provided by the European Opendata Portal: CORDIS opendata.

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