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How intraflagellar transport shapes the cilium: a single-molecule systems study

Total Cost €


EC-Contrib. €






 HITSCIL project word cloud

Explore the words cloud of the HITSCIL project. It provides you a very rough idea of what is the project "HITSCIL" about.

fundamental    experiments    transport    vice    fascinating    critically    chemosensory    repellent    maintenance    perturbations    versa    exposure    shed    instrumentation    living    preliminary    intraflagellar    quantify    unprecedented    zoom    water    elegans    sensors    function    quantitative    toolbox    axoneme    antennas    push    dynamics    cilia    intracellular    ift    specialized    fluorescent    length    solutions    microtubule    single    substantially    nbsp    molecules    fluorescence    place    sense    perspective    ciliary    cooperation    eukaryotic    indicated    sensing    microtubules    signalling    organelles    visualize    organelle    cells    animals    shown    environment    laboratory    light    mechanism    understand    functions    enveloped    proteins    relationship    sensory    animal    position    lab    directional    consist    regulated    structure    molecule    disturbances    connection    external    driving    probes    membrane    soluble    motor    tools    microscopy    axonemal    chemotaxis    dynamically   

Project "HITSCIL" data sheet

The following table provides information about the project.


Organization address
address: DE BOELELAAN 1105
postcode: 1081 HV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙499˙580 €
 EC max contribution 2˙499˙580 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 2˙499˙580.00


 Project objective

Sensory cilia are organelles extending like antennas from many eukaryotic cells, with crucial functions in sensing and signalling. Cilia consist of an axoneme built of microtubules, enveloped by a specialized membrane. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). In my laboratory, we study the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environment for chemotaxis. Over the past years, we have developed a unique set of quantitative, single-molecule fluorescence microscopy tools that allow us to visualize and quantify IFT dynamics with unprecedented detail in living animals. So far, our focus has been on the cooperation of the motor proteins driving IFT. The overall objective of my current proposal is to zoom out and shed light on the connection between ciliary structure, chemosensory function and IFT, from a systems perspective. Recent work has indicated that axoneme length is controlled by IFT. Preliminary results from my laboratory show that axoneme length changes dynamically in response to perturbations of IFT or cilia. Furthermore, we have shown that IFT is substantially affected upon exposure of animals to known repellent solutions. The four major aims in my proposal are to: • determine how directional changes in IFT are regulated and are affected by external disturbances, • understand the dynamics of the axonemal microtubules and how IFT affects these dynamics and vice versa, • study how sensory ciliary function affects IFT and ciliary structure, • further develop our (single-molecule) fluorescence microscopy toolbox by improving instrumentation and using better fluorescent probes and sensors. These experiments will place my lab in a unique position to push forward our understanding of the relationship between structure, function and dynamics of transport of this fascinating and fundamental organelle.

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The information about "HITSCIL" are provided by the European Opendata Portal: CORDIS opendata.

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