Opendata, web and dolomites

INVADERS SIGNED

Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INVADERS project word cloud

Explore the words cloud of the INVADERS project. It provides you a very rough idea of what is the project "INVADERS" about.

relationship    benefits    clinical    distance    dire    morbid    protect    appropriately    previously    modulate    inner    reported    central    inflammation    encroachment    community    promotion    costly    promoted    abnormalities    diverse    investigation    cardiovascular    counteract    hypothesis    provides    overwhelm    models    incidence    preclinical    inter    threatens    layer    diseases    herein    penetrate    bacteria    epithelial    detrimentally    grade    drive    hepatic    resistance    class    mechanism    steatosis    disease    economies    alterations    microbiota    intestinal    inhabited    hyperlipidemia    metabolic    altogether    hyperglycemia    invaders    safe    maintained    additives    tract    inflammatory    ultimately    public    monolayer    chronic    penetrating    homeostasis    host    mucus    therapeutic    genetic    world    care    cell    insulin    disturbance    obesity    emulsifiers    health    epidemic    humanity    ing    characterization    disorders    collectively    alter    downstream    food    original    stably    mechanisms    ubiquitous   

Project "INVADERS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙850˙000 €
 EC max contribution 1˙850˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙850˙000.00

Map

 Project objective

Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease

Humanity is facing an epidemic of inter-related metabolic disorders, including obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hepatic steatosis, that altogether have major impact on the promotion of cardiovascular diseases. The increasing incidence of these complex metabolic disorders and their highly morbid, chronic and costly downstream diseases threatens to overwhelm the world’s health care systems and economies, making it a top public health priority in dire need of investigation. The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the intestinal microbiota. When stably maintained at an appropriately safe distance from the epithelial cell monolayer, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship, promoted by genetic or non-genetic factors, can alter intestinal homeostasis and drive chronic low-grade intestinal inflammation, ultimately leading to metabolic abnormalities. We previously reported that a ubiquitous class of food additives, emulsifiers, detrimentally impact the microbiota resulting in its encroachment into the mucus layer that associated with low-grade inflammation and development of metabolic disorders. The central goal of this proposal is to investigate the hypothesis that bacteria that penetrate the inner part of the mucus layer, referred as invaders, promote development of metabolic alterations. We herein propose to identify mucus-invaders, in preclinical models and clinical conditions, and investigate mechanisms by which they promote inflammatory and metabolic abnormalities. Furthermore, we propose to define original approaches to modulate the intestinal microbiota in order to counteract microbiota encroachment and protect against associated metabolic abnormalities.

 Publications

year authors and title journal last update
List of publications.
2019 Hao Q. Tran, Ruth E. Ley, Andrew T. Gewirtz, Benoit Chassaing
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13538-y
Nature Communications 10/1 2020-02-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INVADERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INVADERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EVOMENS (2020)

The evolution of menstruation in primates

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

ECOLBEH (2020)

The Ecology of Collective Behaviour

Read More