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INVADERS SIGNED

Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 INVADERS project word cloud

Explore the words cloud of the INVADERS project. It provides you a very rough idea of what is the project "INVADERS" about.

disease    class    abnormalities    hypothesis    relationship    previously    food    diseases    emulsifiers    host    inhabited    bacteria    mechanisms    mucus    protect    reported    intestinal    homeostasis    health    overwhelm    ubiquitous    diverse    additives    incidence    inflammation    benefits    drive    public    therapeutic    dire    stably    downstream    penetrate    microbiota    mechanism    alterations    genetic    herein    characterization    investigation    alter    encroachment    promoted    appropriately    humanity    steatosis    detrimentally    invaders    distance    penetrating    collectively    threatens    original    safe    chronic    care    metabolic    maintained    promotion    disorders    inflammatory    ing    provides    clinical    resistance    morbid    central    models    costly    inter    obesity    world    layer    preclinical    epithelial    tract    altogether    insulin    hepatic    grade    ultimately    monolayer    economies    hyperlipidemia    cardiovascular    disturbance    community    counteract    epidemic    hyperglycemia    modulate    cell    inner   

Project "INVADERS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙850˙000 €
 EC max contribution 1˙850˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙850˙000.00

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 Project objective

Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease

Humanity is facing an epidemic of inter-related metabolic disorders, including obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hepatic steatosis, that altogether have major impact on the promotion of cardiovascular diseases. The increasing incidence of these complex metabolic disorders and their highly morbid, chronic and costly downstream diseases threatens to overwhelm the world’s health care systems and economies, making it a top public health priority in dire need of investigation. The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the intestinal microbiota. When stably maintained at an appropriately safe distance from the epithelial cell monolayer, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship, promoted by genetic or non-genetic factors, can alter intestinal homeostasis and drive chronic low-grade intestinal inflammation, ultimately leading to metabolic abnormalities. We previously reported that a ubiquitous class of food additives, emulsifiers, detrimentally impact the microbiota resulting in its encroachment into the mucus layer that associated with low-grade inflammation and development of metabolic disorders. The central goal of this proposal is to investigate the hypothesis that bacteria that penetrate the inner part of the mucus layer, referred as invaders, promote development of metabolic alterations. We herein propose to identify mucus-invaders, in preclinical models and clinical conditions, and investigate mechanisms by which they promote inflammatory and metabolic abnormalities. Furthermore, we propose to define original approaches to modulate the intestinal microbiota in order to counteract microbiota encroachment and protect against associated metabolic abnormalities.

 Publications

year authors and title journal last update
List of publications.
2019 Hao Q. Tran, Ruth E. Ley, Andrew T. Gewirtz, Benoit Chassaing
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13538-y
Nature Communications 10/1 2020-02-05

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