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An Implantable Peritoneal Ultrafiltration Device that actively and continuously prevents fluid overload in congestive heart failure patients

Total Cost €


EC-Contrib. €






 IPUD project word cloud

Explore the words cloud of the IPUD project. It provides you a very rough idea of what is the project "IPUD" about.

efficacy    congestion    recurrence    quality    24    treatments    people    reduce    shock    absorbs    preclinical    eliminates    million    peritoneal    diuresis    paragate    monitoring    catheter    dialysis    direct    intravenous    aggressive    recurred    acute    chf    patients    fluid    validation    healthcare    arrhythmia    thanks    moderate    accumulation    eliminating    complications    minimally    device    significantly    body    continuous    chronic    verification    worsening    instability    pump    pilot    hospitalizations    prevent    removal    therapy    carry    billion    medical    drains    overload    guarantees    hemodynamic    isotonic    invasive    treatment    health    26    validate    function    severe    diuretic    patient    resistant    metabolic    slowly    life    extracellular    implantable    fluids    ultrafiltration    congestive    safety    platform    water    perform    volume    infusion    global    preventing    sensing    worldwide    solutions    systemic    urinary    clinical    physicians    accumulates    pathologic    frequent    ipud    trial    renal    heart    laparoscopic   

Project "IPUD" data sheet

The following table provides information about the project.


Organization address
address: 13 WADI EL HADJ
postcode: n.a.
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙909˙785 €
 EC max contribution 2˙036˙849 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PARAGATE MEDICAL LTD IL (NAZARETH) coordinator 2˙036˙849.00


 Project objective

Pathologic fluid overload (congestion) is a medical condition when high volume of fluid (water) accumulates in the body leading to congestive heart failure (CHF). CHF is a severe global health problem affecting each year ~26 million people worldwide, of which 8 million are chronic and diuretic resistant patients. Current solutions for fluid overload in diuretic resistant patients such as infusion pump for intravenous (IV) diuresis, catheter-based device for ultrafiltration therapy and peritoneal dialysis all carry complications and are acute treatments which do not prevent recurrence. Paragate developed IPUD a unique implantable peritoneal ultrafiltration system for continuous monitoring and removal of extracellular fluids in CHF patients. It is minimally invasive (laparoscopic approach) and continuously (24/7) and slowly absorbs systemic isotonic extracellular fluid and drains it to the urinary system preventing recurred accumulation. In addition, IPUD guarantees a continuous monitoring of the fluid as well as the urinary system function thanks to a sensing system (embedded into the implantable system) and a treatment management platform. In this way, physicians have a direct control of the treatment and patient’s condition. The controlled, moderate non-aggressive fluid removal eliminates the main complications associated with the acute and aggressive treatments that lead to hemodynamic shock, worsening of renal function, arrhythmia and metabolic instability. Thanks to IPUD, patients will improve their quality of life eliminating frequent hospitalizations with a more effective treatment and healthcare systems will significantly reduce the €100 billion/year cost for frequent hospitalizations and treatment costs. The Phase 2 project will enable Paragate to scale-up production, perform validation and verification activities including a preclinical study; and validate the safety and efficacy of IPUD in a pilot clinical trial.

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The information about "IPUD" are provided by the European Opendata Portal: CORDIS opendata.

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