Opendata, web and dolomites

Magicbullet Reloaded SIGNED

Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Magicbullet Reloaded project word cloud

Explore the words cloud of the Magicbullet Reloaded project. It provides you a very rough idea of what is the project "Magicbullet Reloaded" about.

idea    antigens    versa    brings    2015    efforts    delivered    array    had    perfectly    stimulate    overcome    interdisciplinary    tissue    expand    efficient    outstanding    selectivity    compound    pharmacokinetic    broad    expanded    smdcs    causing    faceted    continuing    magicbullet    synthesize    special    disease    refers    drugs    pharmacology    molecule    death    esrs    organic    complementarity    industry    vision    antitumor    immune    environment    642004    toxin    biochemistry    recruited    title    grant    resistance    drug    basis    etn    physiology    bold    cells    implication    biology    expert    academia    premature    agent    kills    therapeutic    despite    conjugates    cell    competences    exposed    treatments    tumor    medicinal    acquired    made    immuno    selectively    scientific    therapy    paul    builds    reloaded    pdcs    peptide    bullet    ideal    ehrlich    1908    2018    small    cancer    substantially    vice    successful    worldwide    chemistry    discovery    organism    magic    direction    nobel    investigation    pipeline    consequence    laureate   

Project "Magicbullet Reloaded" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BIELEFELD 

Organization address
address: UNIVERSITAETSSTRASSE 25
city: BIELEFELD
postcode: 33615
website: www.uni-bielefeld.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙915˙902 €
 EC max contribution 3˙915˙902 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BIELEFELD DE (BIELEFELD) coordinator 252˙788.00
2    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 303˙172.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 281˙276.00
4    PHILOCHEM AG CH (OTELFINGEN) participant 281˙276.00
5    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 280˙805.00
6    EXIRIS SRL IT (ROMA) participant 261˙499.00
7    TAKIS SRL IT (ROMA) participant 261˙499.00
8    UNIVERSITA DEGLI STUDI DELL'INSUBRIA IT (VARESE) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 261˙499.00
10    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 252˙788.00
11    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 252˙788.00
12    TECHNISCHE UNIVERSITAT DARMSTADT DE (DARMSTADT) participant 252˙788.00
13    UNIVERSITAET ZU KOELN DE (KOELN) participant 252˙788.00
14    EOTVOS LORAND TUDOMANYEGYETEM HU (BUDAPEST) participant 229˙715.00
15    Orszagos Onkologiai Intezet HU (Budapest) participant 229˙715.00

Map

 Project objective

'Despite the continuing development of new and more efficient treatments, cancer remains the second cause of premature death worldwide. Multi-faceted interdisciplinary research efforts in industry and academia on different aspects of cancer have provided a knowledge basis for the development of novel therapeutic approaches. Paul Ehrlich, Nobel laureate in Physiology of 1908, had the early vision that a compound could be made to selectively target a disease-causing organism or tumor. A toxin for the particular tissue could be delivered by an agent of selectivity. Such an ideal therapeutic agent would be a 'magic bullet' that only kills the target cells. This ETN initiative with the title Magicbullet::reloaded refers to Ehrlich’s bold idea and builds on the previous experience of the highly successful ETN MAGICBULLET (2015-2018, grant agreement No. 642004). As a consequence of the outstanding results, the ETN Magicbullet::reloaded will expand the field of investigation from peptide-drug conjugates (PDCs) to small molecule-drug conjugates (SMDCs) with a special focus on drugs capable to stimulate tumor immune responses and overcome resistance to immuno-therapy. The consortium has been substantially expanded to perfectly address the needs of the new research direction. The planned ETN will design and synthesize an array of SMDCs (including PDCs), also targeting less investigated tumor antigens, investigate their pharmacokinetic behaviour, their implication on the immune system, as well as their tumor selectivity and antitumor activity. The consortium brings together interdisciplinary expert knowledge in Organic Chemistry, Peptide Chemistry, Medicinal Chemistry, Drug Discovery, Biochemistry, Pharmacology and Cell Biology. This high complementarity is required for the different scientific tasks in the development pipeline. Vice versa, the recruited ESRs will be exposed to a challenging research environment leading to a broad range of scientific competences to be acquired.'

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MAGICBULLET RELOADED" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MAGICBULLET RELOADED" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.1.)

i-CONN (2019)

Interdisciplinary connectivity: Understanding and managing complex systems using connectivity science

Read More  

CHANGE (2019)

Cultural Heritage Analysis for New GEnerations

Read More  

Shape-IT (2019)

Supporting the interaction of Humans and Automated vehicles: Preparing for the EnvIronment of Tomorrow

Read More