Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.
The following table provides information about the project.
|Coordinator Country||Switzerland [CH]|
|Total cost||6˙256˙758 €|
|EC max contribution||6˙256˙758 € (100%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2020-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||AO-FORSCHUNGSINSTITUT DAVOS||CH (DAVOS PLATZ)||coordinator||710˙750.00|
|2||UNIVERSITE DE BORDEAUX||FR (BORDEAUX)||participant||1˙117˙558.00|
|3||UNIVERSITEIT MAASTRICHT||NL (MAASTRICHT)||participant||999˙748.00|
|4||UNIVERSITAT BASEL||CH (BASEL)||participant||659˙570.00|
|5||ETHRIS GMBH||DE (PLANEGG)||participant||490˙526.00|
|6||EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH||DE (ST INGBERT)||participant||457˙500.00|
|7||OZ BIOSCIENCES SAS||FR (MARSEILLE)||participant||447˙750.00|
|8||FUNDACION CIDETEC||ES (SAN SEBASTIAN)||participant||443˙500.00|
|9||KUROS BIOSCIENCES BV||NL (BILTHOVEN)||participant||435˙138.00|
|10||FUNDACION IDONIAL||ES (GIJON)||participant||310˙500.00|
|11||QBEX GMBH||AT (KLAGENFURT)||participant||184˙216.00|
Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.
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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.
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