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cmRNAbone SIGNED

3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Total Cost €

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EC-Contrib. €

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Partnership

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 cmRNAbone project word cloud

Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.

medical    lipids    group    socio    functional    endothelial    presenting    sema3a    formulations    printed    peptides    fabrication    bb    printing    fracture    ingrowth    style    auditing    human    regenerative    modified    ink    commercial    consisting    chemically    regulatory    polysaccharide    printer    bioprinting    deciphering    1st    optimizing    economic    solution    bone    therapies    osteogenesis    until    calcium    promises    extrusion    due    pdgf    industrialized    loading    solutions    effort    overreaching    osteoporosis    amenable    clinical    realized    trial    conjunction    mechanisms    3d    injuries    vivo    experts    preparing    neurons    ratio    vasculogenesis    biomaterial    ageing    preclinical    laminin    synthesized    enormous    loaded    formulated    cells    release    life    cmrnabone    phosphate    keeping    hyaluronan    intrinsic    patient    sensory    facilities    create    nanocapsules    clinically    proof    tools    strategies    patients    bmp7    guiding    vegf    candidate    gmp    combination    vitro    dosage    nations    traumatic    cmrnas    rnas    osteoinductivity    fragile    failed    neurogenesis    therapeutic    vectors   

Project "cmRNAbone" data sheet

The following table provides information about the project.

Coordinator
AO-FORSCHUNGSINSTITUT DAVOS 

Organization address
address: CLAVADELERSTRASSE 8
city: DAVOS PLATZ
postcode: 7270
website: www.aofoundation.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 6˙256˙758 €
 EC max contribution 6˙256˙758 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AO-FORSCHUNGSINSTITUT DAVOS CH (DAVOS PLATZ) coordinator 710˙750.00
2    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 1˙117˙558.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 999˙748.00
4    UNIVERSITAT BASEL CH (BASEL) participant 659˙570.00
5    ETHRIS GMBH DE (PLANEGG) participant 490˙526.00
6    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 457˙500.00
7    OZ BIOSCIENCES SAS FR (MARSEILLE) participant 447˙750.00
8    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 443˙500.00
9    KUROS BIOSCIENCES BV NL (BILTHOVEN) participant 435˙138.00
10    FUNDACION IDONIAL ES (GIJON) participant 310˙500.00
11    QBEX GMBH AT (KLAGENFURT) participant 184˙216.00

Map

 Project objective

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.

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