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cmRNAbone SIGNED

3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Total Cost €

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EC-Contrib. €

0

Partnership

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 cmRNAbone project word cloud

Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.

preparing    trial    traumatic    optimizing    bb    solution    1st    patients    regenerative    biomaterial    group    fragile    bioprinting    bmp7    vitro    vegf    printing    gmp    clinical    bone    calcium    proof    fabrication    cmrnabone    facilities    consisting    laminin    human    therapeutic    printer    failed    guiding    overreaching    peptides    promises    enormous    medical    cmrnas    extrusion    phosphate    nanocapsules    intrinsic    commercial    rnas    neurons    osteoinductivity    functional    due    modified    loading    patient    preclinical    printed    neurogenesis    sensory    nations    ratio    vectors    synthesized    cells    osteoporosis    loaded    until    osteogenesis    clinically    mechanisms    experts    pdgf    socio    ink    formulated    3d    ageing    sema3a    polysaccharide    candidate    style    chemically    strategies    vivo    amenable    ingrowth    tools    regulatory    economic    fracture    hyaluronan    lipids    combination    formulations    release    industrialized    deciphering    endothelial    vasculogenesis    injuries    auditing    create    conjunction    presenting    therapies    realized    effort    solutions    life    keeping    dosage   

Project "cmRNAbone" data sheet

The following table provides information about the project.

Coordinator
AO-FORSCHUNGSINSTITUT DAVOS 

Organization address
address: CLAVADELERSTRASSE 8
city: DAVOS PLATZ
postcode: 7270
website: www.aofoundation.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 6˙256˙758 €
 EC max contribution 6˙256˙758 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AO-FORSCHUNGSINSTITUT DAVOS CH (DAVOS PLATZ) coordinator 710˙750.00
2    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 1˙117˙558.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 999˙748.00
4    UNIVERSITAT BASEL CH (BASEL) participant 659˙570.00
5    ETHRIS GMBH DE (PLANEGG) participant 490˙526.00
6    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 457˙500.00
7    OZ BIOSCIENCES SAS FR (MARSEILLE) participant 447˙750.00
8    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 443˙500.00
9    KUROS BIOSCIENCES BV NL (BILTHOVEN) participant 435˙138.00
10    FUNDACION IDONIAL ES (GIJON) participant 310˙500.00
11    QBEX GMBH AT (KLAGENFURT) participant 184˙216.00

Map

 Project objective

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.

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