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cmRNAbone SIGNED

3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Total Cost €

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EC-Contrib. €

0

Partnership

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 cmRNAbone project word cloud

Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.

laminin    sensory    fabrication    life    human    facilities    presenting    strategies    lipids    overreaching    patients    extrusion    vegf    trial    loading    effort    preparing    therapies    1st    dosage    ratio    formulated    cmrnabone    vectors    calcium    peptides    experts    candidate    bioprinting    mechanisms    synthesized    hyaluronan    preclinical    until    injuries    fragile    vitro    vivo    ageing    functional    printed    create    consisting    traumatic    osteoporosis    combination    ink    gmp    tools    medical    industrialized    biomaterial    endothelial    printer    chemically    amenable    conjunction    failed    neurogenesis    style    vasculogenesis    ingrowth    pdgf    optimizing    auditing    formulations    regenerative    fracture    regulatory    osteogenesis    patient    guiding    intrinsic    due    release    promises    clinically    bmp7    rnas    cells    group    bb    modified    commercial    deciphering    proof    bone    polysaccharide    keeping    realized    printing    loaded    socio    neurons    sema3a    nations    enormous    therapeutic    phosphate    3d    cmrnas    nanocapsules    clinical    solution    osteoinductivity    economic    solutions   

Project "cmRNAbone" data sheet

The following table provides information about the project.

Coordinator
AO-FORSCHUNGSINSTITUT DAVOS 

Organization address
address: CLAVADELERSTRASSE 8
city: DAVOS PLATZ
postcode: 7270
website: www.aofoundation.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 6˙256˙758 €
 EC max contribution 6˙256˙758 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AO-FORSCHUNGSINSTITUT DAVOS CH (DAVOS PLATZ) coordinator 710˙750.00
2    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 1˙117˙558.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 999˙748.00
4    UNIVERSITAT BASEL CH (BASEL) participant 659˙570.00
5    ETHRIS GMBH DE (PLANEGG) participant 490˙526.00
6    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 457˙500.00
7    OZ BIOSCIENCES SAS FR (MARSEILLE) participant 447˙750.00
8    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 443˙500.00
9    KUROS BIOSCIENCES BV NL (BILTHOVEN) participant 435˙138.00
10    FUNDACION IDONIAL ES (GIJON) participant 310˙500.00
11    QBEX GMBH AT (KLAGENFURT) participant 184˙216.00

Map

 Project objective

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-05-17 13:21:41) correctly updated