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cmRNAbone SIGNED

3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Total Cost €

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EC-Contrib. €

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Partnership

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 cmRNAbone project word cloud

Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.

cmrnas    auditing    therapies    1st    mechanisms    neurons    neurogenesis    synthesized    life    enormous    3d    pdgf    proof    regenerative    formulations    sensory    bone    injuries    fragile    therapeutic    optimizing    candidate    patient    economic    keeping    commercial    bioprinting    consisting    peptides    functional    create    due    regulatory    preclinical    promises    polysaccharide    bb    trial    laminin    conjunction    ageing    group    calcium    until    human    vitro    printer    overreaching    socio    solution    sema3a    intrinsic    printed    rnas    release    fabrication    osteoporosis    bmp7    ink    deciphering    osteoinductivity    ingrowth    ratio    failed    medical    extrusion    guiding    loading    cmrnabone    endothelial    solutions    style    biomaterial    printing    vivo    dosage    vasculogenesis    clinically    lipids    combination    nations    nanocapsules    realized    tools    industrialized    facilities    presenting    amenable    effort    gmp    osteogenesis    modified    preparing    clinical    fracture    strategies    cells    patients    traumatic    loaded    phosphate    experts    hyaluronan    formulated    chemically    vegf    vectors   

Project "cmRNAbone" data sheet

The following table provides information about the project.

Coordinator
AO-FORSCHUNGSINSTITUT DAVOS 

Organization address
address: CLAVADELERSTRASSE 8
city: DAVOS PLATZ
postcode: 7270
website: www.aofoundation.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 6˙256˙758 €
 EC max contribution 6˙256˙758 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AO-FORSCHUNGSINSTITUT DAVOS CH (DAVOS PLATZ) coordinator 710˙750.00
2    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 1˙117˙558.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 999˙748.00
4    UNIVERSITAT BASEL CH (BASEL) participant 659˙570.00
5    ETHRIS GMBH DE (PLANEGG) participant 490˙526.00
6    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 457˙500.00
7    OZ BIOSCIENCES SAS FR (MARSEILLE) participant 447˙750.00
8    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 443˙500.00
9    KUROS BIOSCIENCES BV NL (BILTHOVEN) participant 435˙138.00
10    FUNDACION IDONIAL ES (GIJON) participant 310˙500.00
11    QBEX GMBH AT (KLAGENFURT) participant 184˙216.00

Map

 Project objective

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.

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