cmRNAbone SIGNED
3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients
Total Cost €
0EC-Contrib. €
0Partnership
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0cmRNAbone project word cloud
Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.
Project "cmRNAbone" data sheet
The following table provides information about the project.
| Coordinator |
AO-FORSCHUNGSINSTITUT DAVOS
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Total cost | 6˙256˙758 € |
| EC max contribution | 6˙256˙758 € (100%) |
| Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
| Code Call | H2020-SC1-2019-Single-Stage-RTD |
| Funding Scheme | RIA |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2023-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AO-FORSCHUNGSINSTITUT DAVOS | CH (DAVOS PLATZ) | coordinator | 710˙750.00 |
| 2 | UNIVERSITE DE BORDEAUX | FR (BORDEAUX) | participant | 1˙117˙558.00 |
| 3 | UNIVERSITEIT MAASTRICHT | NL (MAASTRICHT) | participant | 999˙748.00 |
| 4 | UNIVERSITAT BASEL | CH (BASEL) | participant | 659˙570.00 |
| 5 | ETHRIS GMBH | DE (PLANEGG) | participant | 490˙526.00 |
| 6 | EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH | DE (ST INGBERT) | participant | 457˙500.00 |
| 7 | OZ BIOSCIENCES SAS | FR (MARSEILLE) | participant | 447˙750.00 |
| 8 | FUNDACION CIDETEC | ES (SAN SEBASTIAN) | participant | 443˙500.00 |
| 9 | KUROS BIOSCIENCES BV | NL (BILTHOVEN) | participant | 435˙138.00 |
| 10 | FUNDACION IDONIAL | ES (GIJON) | participant | 310˙500.00 |
| 11 | QBEX GMBH | AT (KLAGENFURT) | participant | 184˙216.00 |
Map
Project objective
Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.
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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.