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GLYCOSWITCH SIGNED

Probing the mysteries of sweet “on-off” switches of the human immune system: toward the development of novel glycomimetics against bacterial infections

Total Cost €

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EC-Contrib. €

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Partnership

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 GLYCOSWITCH project word cloud

Explore the words cloud of the GLYCOSWITCH project. It provides you a very rough idea of what is the project "GLYCOSWITCH" about.

diseases    opening    chemistry    strategies    multidisciplinary    techniques    molecular    immune    tremendous    avenues    attractive    recognition    holistic    bacterial    function    nmr    cancer    groundbreaking    human    directed    spanning    innovative    negative    organisms    paramount    infections    chemical    biochemistry    fill    virulent    detection    comprehension    basis    mediated    gram    normal    organic    glycoswitch    huge    microbial    synthetic    mechanisms    biomedicine    special    promise    autoimmune    decade    invasive    glycomimetics    viral    reverse    gap    etiology    chemist    disorders    decipher    despite    proteins    receptor    expertise    glycoscience    manifold    glycome    boost    spectroscopy    unlock    protein    modulate    resolution    pathogen    secondary    incomplete    approaching    bacteria    glycans    interaction    ultimate    massively    last    picture    physiology    significantly    biology    glycan    diagnostics    biophysics    host    immunosuppression    deciphering    health    holds    combining   

Project "GLYCOSWITCH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙994˙117 €
 EC max contribution 1˙994˙117 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙994˙117.00

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 Project objective

Glycans are directly involved in the normal physiology and in the etiology of several major diseases, spanning from bacterial and viral infections through to cancer and autoimmune disorders. Thus, deciphering the glycome holds huge promise to provide new targets and diagnostics for human health.

Despite the tremendous advance of knowledge in the field of Glycoscience during the last decade, the comprehension at high resolution of the molecular basis of many pathogen-mediated diseases is still incomplete. GLYCOSWITCH will significantly contribute to fill this gap, providing a holistic picture of the manifold mechanisms of host responses to microbial infections, with a special focus on Gram-negative bacteria. I propose to address bacterial glycans recognition by host immune proteins by using a multidisciplinary approach, combining state-of-the-art synthetic organic chemistry, molecular biology, biochemistry and biophysics techniques, massively including NMR spectroscopy. I will apply them in an innovative integrated chemical biology approach in order to decipher key glycan recognition aspects beyond current knowledge. Understanding of molecular mechanisms of detection of invasive virulent bacteria by host organisms will allow to reach the ultimate goal of GLYCOSWITCH project: the design and development of novel and effective glycomimetics able to modulate the function of host immune receptor proteins.

The success of GLYCOSWITCH will unlock attractive opportunities for the development of host-directed strategies to boost the immune response or reverse pathogen-induced immunosuppression.

My unique approach to this project, as an organic chemist with wide expertise in NMR and bacterial glycans, will provide groundbreaking information on protein-glycan interaction systems of paramount importance in biology and biomedicine, opening new avenues for approaching bacterial diseases and their secondary effects.

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The information about "GLYCOSWITCH" are provided by the European Opendata Portal: CORDIS opendata.

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