Opendata, web and dolomites

GLYCOSWITCH SIGNED

Probing the mysteries of sweet “on-off” switches of the human immune system: toward the development of novel glycomimetics against bacterial infections

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GLYCOSWITCH project word cloud

Explore the words cloud of the GLYCOSWITCH project. It provides you a very rough idea of what is the project "GLYCOSWITCH" about.

disorders    massively    gram    avenues    immune    mediated    glycome    promise    glycoswitch    huge    strategies    interaction    secondary    special    directed    molecular    deciphering    glycan    nmr    etiology    chemistry    picture    basis    fill    biology    glycans    last    diagnostics    incomplete    innovative    viral    decipher    mechanisms    opening    ultimate    biomedicine    modulate    biochemistry    synthetic    manifold    glycoscience    protein    normal    attractive    glycomimetics    detection    cancer    function    approaching    pathogen    microbial    expertise    combining    human    organic    reverse    techniques    spectroscopy    autoimmune    despite    boost    gap    proteins    biophysics    bacterial    tremendous    recognition    organisms    comprehension    negative    unlock    chemical    multidisciplinary    receptor    resolution    holds    groundbreaking    health    bacteria    spanning    host    decade    physiology    invasive    chemist    immunosuppression    significantly    paramount    infections    diseases    virulent    holistic   

Project "GLYCOSWITCH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙994˙117 €
 EC max contribution 1˙994˙117 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙994˙117.00

Map

 Project objective

Glycans are directly involved in the normal physiology and in the etiology of several major diseases, spanning from bacterial and viral infections through to cancer and autoimmune disorders. Thus, deciphering the glycome holds huge promise to provide new targets and diagnostics for human health.

Despite the tremendous advance of knowledge in the field of Glycoscience during the last decade, the comprehension at high resolution of the molecular basis of many pathogen-mediated diseases is still incomplete. GLYCOSWITCH will significantly contribute to fill this gap, providing a holistic picture of the manifold mechanisms of host responses to microbial infections, with a special focus on Gram-negative bacteria. I propose to address bacterial glycans recognition by host immune proteins by using a multidisciplinary approach, combining state-of-the-art synthetic organic chemistry, molecular biology, biochemistry and biophysics techniques, massively including NMR spectroscopy. I will apply them in an innovative integrated chemical biology approach in order to decipher key glycan recognition aspects beyond current knowledge. Understanding of molecular mechanisms of detection of invasive virulent bacteria by host organisms will allow to reach the ultimate goal of GLYCOSWITCH project: the design and development of novel and effective glycomimetics able to modulate the function of host immune receptor proteins.

The success of GLYCOSWITCH will unlock attractive opportunities for the development of host-directed strategies to boost the immune response or reverse pathogen-induced immunosuppression.

My unique approach to this project, as an organic chemist with wide expertise in NMR and bacterial glycans, will provide groundbreaking information on protein-glycan interaction systems of paramount importance in biology and biomedicine, opening new avenues for approaching bacterial diseases and their secondary effects.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLYCOSWITCH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLYCOSWITCH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More