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SPECIPHIC SIGNED

Label-free quantitative nanoscopy for molecular specific identification at depth in pristine living biological tissues

Total Cost €

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EC-Contrib. €

0

Partnership

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 SPECIPHIC project word cloud

Explore the words cloud of the SPECIPHIC project. It provides you a very rough idea of what is the project "SPECIPHIC" about.

physics    elementary    resolution    function    algorithms    medicine    microscopy    tool    questions    pristine    untangled    probes    sensor    societal    engineering    optical    sensitivity    label    machine    ground    breaking    nanomaterial    resolutions    shot    signature    imaging    biological    limit    dogmas    single    improper    intensity    speciphic    retrieved    revolution    labelling    nanoscopic    demonstrates    samples    molecular    applicability    tissues    demonstrated    regenerative    introducing    deep    starting    nanoscale    beating    identification    inevitably    specificity    give    learning    impacting    birth    index    fluorescent    molecules    medical    blocks    pioneering    paradigm    first    alters    interaction    technique    free    undergone    exchange    refractive    oncology    living    forge    re    inside    nanoscopy    absorption    biomedical    world    vibrational    unmodified    building    tagging    complete    equivalent    biomolecules    erc    regular    quantitatively    unprecedented    polarisation    energy    decipher   

Project "SPECIPHIC" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙016 €
 EC max contribution 1˙499˙016 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙016.00

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 Project objective

Optical microscopy has undergone a revolution that now allows us to access molecular resolution (“nanoscopy”) with the identification of specific biomolecules within biological samples. Nanoscopy has become a key approach to decipher the function of living matter since biomolecules are the elementary building blocks. While being a major tool, high-resolution and specificity can only be achieved by tagging the molecules of interest with fluorescent probes, which inevitably alters the samples, making them improper for medical applications including regenerative medicine. The leading dogmas being that (i) nanoscopy cannot be achieved without labelling and (ii) no specific signature from molecules can be retrieved without energy exchange with the sample (e.g. absorption by probes, molecular vibrational interaction). I propose a complete change of paradigm by introducing label-free nanoscopic imaging using the optical refractive index as a molecular sensor. My ground-breaking approach will be based on our pioneering work which demonstrates that phase, intensity and polarisation information can be quantitatively retrieved with unprecedented sensitivity and with an imaging resolution equivalent to regular imaging with fluorescent probes. I will re-forge this into a single-shot imaging technique capable of beating the optical resolution limit to access nanoscale resolutions, even deep inside living unmodified biological samples. Specific molecular information will be untangled through machine learning algorithms. SPECIPHIC will give birth to the first label-free molecular specific imaging with nanoscale resolution in pristine living biological tissues. The applicability of my concept will be demonstrated in this ERC starting project with applications in regenerative medicine and oncology, impacting thus directly important societal questions. My new approach will impact many other fields, in the biomedical world first but also in physics and for nanomaterial engineering.

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The information about "SPECIPHIC" are provided by the European Opendata Portal: CORDIS opendata.

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