Opendata, web and dolomites


Label-free quantitative nanoscopy for molecular specific identification at depth in pristine living biological tissues

Total Cost €


EC-Contrib. €






 SPECIPHIC project word cloud

Explore the words cloud of the SPECIPHIC project. It provides you a very rough idea of what is the project "SPECIPHIC" about.

forge    complete    physics    impacting    nanoscale    questions    revolution    applicability    specificity    machine    regenerative    ground    identification    dogmas    polarisation    speciphic    engineering    nanomaterial    probes    biomedical    molecular    societal    give    inevitably    oncology    resolution    optical    untangled    intensity    limit    signature    unmodified    tissues    single    demonstrated    refractive    sensitivity    tagging    interaction    world    paradigm    learning    resolutions    technique    inside    first    medicine    absorption    biological    decipher    tool    quantitatively    living    function    pristine    energy    breaking    index    labelling    starting    demonstrates    unprecedented    building    nanoscopy    free    medical    re    deep    biomolecules    alters    algorithms    sensor    retrieved    nanoscopic    birth    introducing    imaging    shot    vibrational    undergone    erc    pioneering    regular    elementary    blocks    fluorescent    exchange    equivalent    beating    improper    microscopy    molecules    label    samples   

Project "SPECIPHIC" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙016 €
 EC max contribution 1˙499˙016 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Optical microscopy has undergone a revolution that now allows us to access molecular resolution (“nanoscopy”) with the identification of specific biomolecules within biological samples. Nanoscopy has become a key approach to decipher the function of living matter since biomolecules are the elementary building blocks. While being a major tool, high-resolution and specificity can only be achieved by tagging the molecules of interest with fluorescent probes, which inevitably alters the samples, making them improper for medical applications including regenerative medicine. The leading dogmas being that (i) nanoscopy cannot be achieved without labelling and (ii) no specific signature from molecules can be retrieved without energy exchange with the sample (e.g. absorption by probes, molecular vibrational interaction). I propose a complete change of paradigm by introducing label-free nanoscopic imaging using the optical refractive index as a molecular sensor. My ground-breaking approach will be based on our pioneering work which demonstrates that phase, intensity and polarisation information can be quantitatively retrieved with unprecedented sensitivity and with an imaging resolution equivalent to regular imaging with fluorescent probes. I will re-forge this into a single-shot imaging technique capable of beating the optical resolution limit to access nanoscale resolutions, even deep inside living unmodified biological samples. Specific molecular information will be untangled through machine learning algorithms. SPECIPHIC will give birth to the first label-free molecular specific imaging with nanoscale resolution in pristine living biological tissues. The applicability of my concept will be demonstrated in this ERC starting project with applications in regenerative medicine and oncology, impacting thus directly important societal questions. My new approach will impact many other fields, in the biomedical world first but also in physics and for nanomaterial engineering.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SPECIPHIC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SPECIPHIC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  


The Mass Politics of Disintegration

Read More  


The Power of Randomness and Continuity in Submodular Optimization

Read More