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VIROME SIGNED

Shaping of long term innate immunity by viral education of bone marrow monocytes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VIROME project word cloud

Explore the words cloud of the VIROME project. It provides you a very rough idea of what is the project "VIROME" about.

regulated    immunophenotyping    underestimated    microbes    fundamental    macrophage    innate    murid    dynamic    single    unbiased    devised    progenitors    shapes    shows    priming    determinant    balance    monocyte    training    disease    assays    induction    cd169    steady    functional    history    niche    pneumonia    immunity    trains    immunomodulation    combination    outcomes    primed    microbial    immune    viruses    heterologous    replenishment    variation    frequently    finely    local    roles    microenvironment    heterogeneous    seq    educated    fate    bone    rna    atac    mechanism    imprinting    play    protective    commensals    shaping    preliminary    mice    literature    environmental    pathogens    trained    host    herpesvirus    shape    shown    anti    regulatory    monocytes    biological    infections    explore    viral    cells    function    macrophages    molecular    first    proof    postulate    education    susceptibility    paradigm    symbiotic    amongst    cell    underlying    pathogenic    interactions    virus    marrow   

Project "VIROME" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LIEGE 

Organization address
address: PLACE DU 20 AOUT 7
city: LIEGE
postcode: 4000
website: www.ulg.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙499˙950 €
 EC max contribution 1˙499˙950 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE BE (LIEGE) coordinator 1˙499˙950.00

Map

 Project objective

Symbiotic and pathogenic microbes are major environmental factors that play fundamental roles in shaping host immunity. Such dynamic interactions between commensals or pathogens and the host must be finely regulated to balance protective immune responses and induction of regulatory pathways. While frequently underestimated, immune imprinting by viruses is a key determinant for variation in disease susceptibility. Numerous evidence shows that a history of infections trains the innate immune system for the long term. Amongst the cells that are trained, monocytes are highly heterogeneous and are involved in essential biological processes such as anti-microbial activity, immunomodulation or macrophage-niche replenishment. While the current paradigm states that monocyte fate and function are driven by the local microenvironment, a recent study has shown that monocytes are primed in the bone marrow for functional properties. Here, we want to explore how and where monocyte development and function are educated by symbiotic (Murid herpesvirus 4) or pathogenic (Pneumonia Virus of Mice) viruses and with which potential outcomes for long-term immunity. To this end, we have devised three main aims. First, following infections, we will characterize monocytes and their progenitors by classical immunophenotyping, functional assays and unbiased single-cell RNA-seq in combination with ATAC-seq, to investigate in-depth how and where viruses shape monocytes and monocyte-derived cells. Second, molecular mechanism(s) underlying monocyte priming after infections will be assessed. In particular, based on literature and preliminary results, we postulate that bone marrow CD169 macrophages could play a key role in early monocyte priming. Third, the consequences of virus-driven monocyte training will be investigated at steady state and upon heterologous challenges. Such research could provide the proof of concept that viral education of bone marrow monocytes shapes long-term innate immunity.

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The information about "VIROME" are provided by the European Opendata Portal: CORDIS opendata.

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