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InflaCare SIGNED

An exosome-based therapeutic approach against chronic inflammation

Total Cost €

EC-Contrib. €

Partnership

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InflaCare project word cloud

Explore the words cloud of the InflaCare project. It provides you a very rough idea of what is the project "InflaCare" about.

complications diseases persistent discovered activation anti metabolic erc triggers cross chronic barrier unmet unlike animal minimal consolidator lowering stimulating extended disorders periods biocompatibility pronounced toxicity inherent preclinical definer innovative therapeutic broad neurodegenerative mice man inflammatory medicine antiviral damage strategy diabetes dna countermeasures onset blood therapies cargo inflammation rheumatoid neurodegeneration sophisticated provides severe signaling brain immune models innate body arthritis circulate devastating premature immunogenic

Project "InflaCare" data sheet

The following table provides information about the project.

Coordinator	IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Total cost	0 €
EC max contribution	150˙000 € (0%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-PoC
Funding Scheme	ERC-POC-LS
Starting year	2020
Duration (year-month-day)	from 2020-05-01 to 2021-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	coordinator	150˙000.00

Map

Project objective

DNA damage triggers the activation of innate immune signaling leading to chronic inflammation and the premature onset of e.g. rheumatoid arthritis, diabetes, metabolic diseases and neurodegenerative disorders in man. Based on our ERC consolidator program DeFiNER, we recently discovered that persistent DNA damage triggers the innate immune system stimulating broad inflammatory and antiviral immune countermeasures that lead to chronic inflammation and the premature onset of severe metabolic complications and neurodegeneration in mice. Here, we propose a sophisticated a therapeutic anti-inflammatory strategy aimed at lowering chronic inflammation in preclinical animal models with pronounced metabolic diseases or neurodegeneration. Unlike available anti-inflammatory therapies, the proposed therapeutic approach is non-immunogenic, allows the therapeutic cargo to circulate for extended periods within the body and to cross the blood brain barrier with no biocompatibility complications and minimal to no inherent toxicity issues in mice. This novel strategy provides, therefore, the means towards an innovative medicine that will effectively address real but unmet therapeutic needs for a wide range of devastating diseases associated with chronic inflammation.

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The information about "INFLACARE" are provided by the European Opendata Portal: CORDIS opendata.