Explore the words cloud of the InflaCare project. It provides you a very rough idea of what is the project "InflaCare" about.
The following table provides information about the project.
IDRYMA TECHNOLOGIAS KAI EREVNAS
|Coordinator Country||Greece [EL]|
|Total cost||0 €|
|EC max contribution||150˙000 € (0%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2020-05-01 to 2021-10-31|
Take a look of project's partnership.
|1||IDRYMA TECHNOLOGIAS KAI EREVNAS||EL (IRAKLEIO)||coordinator||150˙000.00|
DNA damage triggers the activation of innate immune signaling leading to chronic inflammation and the premature onset of e.g. rheumatoid arthritis, diabetes, metabolic diseases and neurodegenerative disorders in man. Based on our ERC consolidator program DeFiNER, we recently discovered that persistent DNA damage triggers the innate immune system stimulating broad inflammatory and antiviral immune countermeasures that lead to chronic inflammation and the premature onset of severe metabolic complications and neurodegeneration in mice. Here, we propose a sophisticated a therapeutic anti-inflammatory strategy aimed at lowering chronic inflammation in preclinical animal models with pronounced metabolic diseases or neurodegeneration. Unlike available anti-inflammatory therapies, the proposed therapeutic approach is non-immunogenic, allows the therapeutic cargo to circulate for extended periods within the body and to cross the blood brain barrier with no biocompatibility complications and minimal to no inherent toxicity issues in mice. This novel strategy provides, therefore, the means towards an innovative medicine that will effectively address real but unmet therapeutic needs for a wide range of devastating diseases associated with chronic inflammation.
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The information about "INFLACARE" are provided by the European Opendata Portal: CORDIS opendata.