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IP-cure-B SIGNED

Immune profiling to guide host-directed interventions to cure HBV infections

Total Cost €

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EC-Contrib. €

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Partnership

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Project "IP-cure-B" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 14˙943˙030 €
 EC max contribution 9˙983˙029 € (67%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 4˙094˙578.00
2    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 1˙593˙800.00
3    UNIVERSITA DEGLI STUDI DI PARMA IT (PARMA) participant 1˙030˙053.00
4    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 850˙000.00
5    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 690˙048.00
6    INSERM - TRANSFERT SA FR (PARIS) participant 300˙000.00
7    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 299˙550.00
8    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) participant 250˙000.00
9    FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO IT (MILANO) participant 250˙000.00
10    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) participant 250˙000.00
11    HOSPICES CIVILS DE LYON FR (LYON) participant 200˙000.00
12    EUROPEAN LIVER PATIENTS ASSOCIATION BE (BRUXELLES) participant 175˙000.00
13    GILEAD SCIENCES INC US (FOSTER CITY CA) participant 0.00
14    SPRING BANK PHARMACEUTICALS INC. US (WILMINGTON) participant 0.00

Map

 Project objective

The objective of the project is to develop novel curative concepts for chronic hepatitis B (CHB). Specific aims will be to: 1) improve the rate of functional cure of CHB by boosting innate immunity with immune modulators and stimulating adaptive immune responses with a novel therapeutic vaccine; ii) characterize immune and viral biomarker signatures for patient stratification and treatment response monitoring; iii) integrate biological and clinical data to model the best combination treatment for future trials; iv) model the effectiveness of novel curative therapies with respect to disease spectrum, patient heterogeneity, and constraints of National Health Systems.

The project organization will combine: i) a Proof of Concept clinical trial of a combination of 2 novel compounds stimulating innate immunity; ii) a preclinical immune therapy platform in humanized mice combining immune-modulatory strategies to stimulate innate immunity, rescue exhausted HBV-specific T cells and generate anti-HBV adaptive responses; iii) extensive virologic and immune profiling to identify correlates of cure in patients, iv) the integration of large biological and clinical datasets, v) a cost-effectiveness modelling of new therapeutic interventions, vi) project management, vii) results exploitation and dissemination.

The proposal responds to the work program by: i) including the evaluation of emerging concepts in drug and vaccine development to discover a curative strategy for CHB, a major public health concern for Europe, ii) capitalizing on knowledge of host-pathogen interactions to develop novel immune-based therapies, iii) considering age, gender and viral genetic variations, iv) comprising a clinical trial and a pre-clinical platform for the discovery of novel immune interventions, and selection of relevant biomarkers for validation in established clinical cohorts, v) addressing conditions for effective uptake of the new curative interventions by National Health Systems.

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The information about "IP-CURE-B" are provided by the European Opendata Portal: CORDIS opendata.

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