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PREFERABLE SIGNED

Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "PREFERABLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 4˙121˙130 €
 EC max contribution 3˙983˙347 € (97%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙025˙436.00
2    JULIUS CLINICAL RESEARCH BV NL (ZEIST) participant 724˙040.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 406˙035.00
4    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 381˙770.00
5    NUROGAMES GMBH DE (KOLN) participant 336˙625.00
6    FUNDACION ONKOLOGIKOA FUNDAZIOA ES (DONOSTIA SAN SEBASTIAN) participant 262˙550.00
7    GDANSKI UNIWERSYTET MEDYCZNY PL (GDANSK) participant 260˙850.00
8    DEUTSCHE SPORTHOCHSCHULE KOLN DE (KOLN) participant 242˙025.00
9    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 235˙025.00
10    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 77˙741.00
11    EUROPA DONNA THE EUROPEAN BREAST CANCER COALITION IT (MILANO) participant 31˙250.00
12    AUSTRALIAN CATHOLIC UNIVERSITY LIMITED AU (NORTH SYDNEY) participant 0.00

Map

 Project objective

Despite the tremendous improvement in early diagnosis and treatment of breast cancer, a large proportion (up to 40%) of patients with breast cancer will eventually develop metastases. Patients with metastatic breast cancer (MBC) have a median overall survival of 2-3 years, and a relative 5-year survival of 34%. Current advances in therapy have extended the life of those patients with MBC, however these patients still suffer (for longer periods) from deleterious side-effects (either related to the disease itself or to the treatment) such as fatigue, pain, nausea and vomiting, insomnia, dyspnoea, emotional, social and cognitive dysfunction. Among all these side-effects, fatigue is the most common and distressing treatment-related side-effect, as up to 90% of patients with MBC experience fatigue over the course of treatment. All these symptoms negatively affect patients’ QoL and thus an urgent solution is needed to help those with advanced breast cancer to “live well” for as long as possible. PREFERABLE’s vision is to improve the standard of care in MBC by improving the quality, effectiveness and cost-effectiveness for patients in a palliative setting using a non-pharmacological intervention combining supervised and unsupervised app-based exercise. Based on the results from a multinational randomised controlled phase 3 clinical trial (EFFECT trial; (cost)- effectiveness study), the different perspectives of patients with MBC on exercising (PERSPECTIVE study), and through mapping the differences in the European healthcare systems, the PREFERABLE project will generate solid and conclusive evidence of the beneficial effect of exercise on cancer-related side effects and patients’ quality of life in the palliative setting. By this, PREFERABLE will contribute towards reshaping medical practice and improving clinical guidelines and recommendations.

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