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PREFERABLE SIGNED

Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life

Total Cost €

EC-Contrib. €

Partnership

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PREFERABLE project word cloud

Explore the words cloud of the PREFERABLE project. It provides you a very rough idea of what is the project "PREFERABLE" about.

deleterious clinical symptoms pain care preferable solid urgent trial disease proportion quality fatigue metastases 40 reshaping palliative setting either combining therapy despite healthcare exercising relative live cognitive treatment nausea dysfunction recommendations tremendous patients qol randomised app dyspnoea median vomiting cancer solution generate medical survival standard negatively suffer diagnosis itself distressing guidelines breast perspectives exercise 34 beneficial 90 life effectiveness metastatic multinational conclusive vision effect extended mbc intervention supervised unsupervised perspective differences social insomnia longer mapping periods emotional improvement pharmacological course

Project "PREFERABLE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	4˙121˙130 €
EC max contribution	3˙983˙347 € (97%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	1˙025˙436.00
2	JULIUS CLINICAL RESEARCH BV JULIUS CLINICAL RESEARCH BV Organization address address: BROEDERPLEIN 41-43 city: ZEIST postcode: 3703 CD website: www.juliusclinical.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ZEIST)	participant	724˙040.00
3	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	406˙035.00
4	STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Organization address address: PLESMANLAAN 121 city: AMSTERDAM postcode: 1066 CX website: www.nki.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	381˙770.00
5	NUROGAMES GMBH NUROGAMES GMBH Organization address address: SCHAAFENSTRASSE 25 city: KOLN postcode: 50676 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOLN)	participant	336˙625.00
6	FUNDACION ONKOLOGIKOA FUNDAZIOA FUNDACION ONKOLOGIKOA FUNDAZIOA Organization address address: PASEO DR BEGUIRISTAIN 121 city: DONOSTIA SAN SEBASTIAN postcode: 20014 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DONOSTIA SAN SEBASTIAN)	participant	262˙550.00
7	GDANSKI UNIWERSYTET MEDYCZNY GDANSKI UNIWERSYTET MEDYCZNY Organization address address: ULICA M SKLODOWSKIEJ CURIE 3A city: GDANSK postcode: 80210 website: http://www.amg.gda.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (GDANSK)	participant	260˙850.00
8	DEUTSCHE SPORTHOCHSCHULE KOLN DEUTSCHE SPORTHOCHSCHULE KOLN Organization address address: AM SPORTPARK MUENGERSDORF 6 city: KOLN postcode: 50933 website: www.dshs-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOLN)	participant	242˙025.00
9	DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 280 city: HEIDELBERG postcode: 69120 website: www.dkfz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	235˙025.00
10	UNIVERSITATSKLINIKUM HEIDELBERG UNIVERSITATSKLINIKUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 website: www.klinikum.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	77˙741.00
11	EUROPA DONNA THE EUROPEAN BREAST CANCER COALITION EUROPA DONNA THE EUROPEAN BREAST CANCER COALITION Organization address address: PIAZZA AMENDOLA 3 city: MILANO postcode: 20149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	31˙250.00
12	AUSTRALIAN CATHOLIC UNIVERSITY LIMITED AUSTRALIAN CATHOLIC UNIVERSITY LIMITED Organization address address: 40 EDWARD STREET city: NORTH SYDNEY postcode: 2060 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (NORTH SYDNEY)	participant	0.00

Map

Project objective

Despite the tremendous improvement in early diagnosis and treatment of breast cancer, a large proportion (up to 40%) of patients with breast cancer will eventually develop metastases. Patients with metastatic breast cancer (MBC) have a median overall survival of 2-3 years, and a relative 5-year survival of 34%. Current advances in therapy have extended the life of those patients with MBC, however these patients still suffer (for longer periods) from deleterious side-effects (either related to the disease itself or to the treatment) such as fatigue, pain, nausea and vomiting, insomnia, dyspnoea, emotional, social and cognitive dysfunction. Among all these side-effects, fatigue is the most common and distressing treatment-related side-effect, as up to 90% of patients with MBC experience fatigue over the course of treatment. All these symptoms negatively affect patients’ QoL and thus an urgent solution is needed to help those with advanced breast cancer to “live well” for as long as possible. PREFERABLE’s vision is to improve the standard of care in MBC by improving the quality, effectiveness and cost-effectiveness for patients in a palliative setting using a non-pharmacological intervention combining supervised and unsupervised app-based exercise. Based on the results from a multinational randomised controlled phase 3 clinical trial (EFFECT trial; (cost)- effectiveness study), the different perspectives of patients with MBC on exercising (PERSPECTIVE study), and through mapping the differences in the European healthcare systems, the PREFERABLE project will generate solid and conclusive evidence of the beneficial effect of exercise on cancer-related side effects and patients’ quality of life in the palliative setting. By this, PREFERABLE will contribute towards reshaping medical practice and improving clinical guidelines and recommendations.

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