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mARs SIGNED

mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 mARs project word cloud

Explore the words cloud of the mARs project. It provides you a very rough idea of what is the project "mARs" about.

promotes    bioinformatics    view    era    virulent    transfer    insights    care    clinical    biology    situ    drugs    model    multidrug    structure    transposons    pathogens    microbial    rare    antibiotic    regulation    significance    meta    drive    resort    biochemistry    mechanisms    cells    disciplines    limited    structural    vitro    bacteria    genetics    implications    dissect    quests    evolution    broad    strategies    interaction    intervention    confer    functional    integrons    functionally    draw    molecular    genes    gut    resistance    gene    movies    diversity    biochemical    reveal    promiscuous    microbiology    natural    combining    reducing    elucidate    unclear    mechanistic    environments    movement    interplay    occurs    annotated    bridging    mobile    bacterial    protein    dna    preventive    bioinformatic    hotspots    humans    underlying    spreading    sparse    health    prevalence    resistant    superbugs    last    ar    genomic    carriers    determinants    communities    machineries    data    spread    chart    drug    gained   

Project "mARs" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙118 €
 EC max contribution 1˙999˙118 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙999˙118.00

Map

 Project objective

Antibiotic resistance (AR) is spreading rapidly, leading to the development of highly virulent pathogens and multidrug-resistant ‘superbugs’, a major health concern of our era. Mobile DNA elements, transposons and integrons, effectively drive the spread of AR genes in microbial interaction hotspots, such as bacterial communities in humans and natural environments. Yet, our knowledge of their mechanisms remains very sparse. It is unclear how DNA movement occurs on the molecular level and how it is controlled in cells and communities; biochemical and structural data are rare and our view on their diversity and evolution is limited. Here I propose an integrated approach combining bioinformatics, genetics, microbiology, biochemistry, and structural biology to elucidate the mechanisms and diversity of mobile DNA driven resistance spreading. I want to (a) investigate the molecular mechanisms and regulation of AR gene movement in vitro, in model bacteria and in gut bacterial communities; (b) dissect the structure of the underlying molecular machineries to reveal how protein-DNA interplay promotes gene transfer; and (c) characterize the diversity, evolution and functional success of distinct molecular pathways. Mechanistic work will focus on selected mobile elements that confer resistance to last resort drugs and promiscuous gene carriers with high prevalence in health care. Bioinformatic quests will draw on recent (meta)genomic data to chart the clinical significance of molecular insights in situ. By bridging disciplines, I want to provide functionally annotated molecular movies of gene movement and explain how specific molecular strategies evolved to enable broad dissemination of resistance determinants. The insights gained in this research will provide in-depth knowledge on major AR transfer pathways and will have key implications for the development of novel intervention strategies and preventive measures aimed at reducing dissemination of drug resistance in bacteria.

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The information about "MARS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-16 7:00:36) correctly updated