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mARs SIGNED

mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 mARs project word cloud

Explore the words cloud of the mARs project. It provides you a very rough idea of what is the project "mARs" about.

preventive    model    promiscuous    microbial    bioinformatic    evolution    broad    antibiotic    genes    chart    microbiology    genetics    virulent    integrons    situ    dna    insights    interplay    combining    significance    quests    biochemistry    vitro    mobile    bacterial    communities    ar    environments    structural    cells    pathogens    confer    health    regulation    bioinformatics    functionally    disciplines    spread    carriers    superbugs    care    transposons    gene    molecular    biology    drug    meta    gut    drive    dissect    machineries    movies    unclear    bridging    occurs    diversity    rare    gained    era    movement    resort    interaction    data    strategies    biochemical    promotes    mechanisms    structure    limited    determinants    drugs    functional    implications    draw    hotspots    clinical    natural    elucidate    sparse    reveal    underlying    multidrug    genomic    annotated    resistance    spreading    view    last    intervention    bacteria    prevalence    resistant    humans    protein    mechanistic    reducing    transfer   

Project "mARs" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙118 €
 EC max contribution 1˙999˙118 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙999˙118.00

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 Project objective

Antibiotic resistance (AR) is spreading rapidly, leading to the development of highly virulent pathogens and multidrug-resistant ‘superbugs’, a major health concern of our era. Mobile DNA elements, transposons and integrons, effectively drive the spread of AR genes in microbial interaction hotspots, such as bacterial communities in humans and natural environments. Yet, our knowledge of their mechanisms remains very sparse. It is unclear how DNA movement occurs on the molecular level and how it is controlled in cells and communities; biochemical and structural data are rare and our view on their diversity and evolution is limited. Here I propose an integrated approach combining bioinformatics, genetics, microbiology, biochemistry, and structural biology to elucidate the mechanisms and diversity of mobile DNA driven resistance spreading. I want to (a) investigate the molecular mechanisms and regulation of AR gene movement in vitro, in model bacteria and in gut bacterial communities; (b) dissect the structure of the underlying molecular machineries to reveal how protein-DNA interplay promotes gene transfer; and (c) characterize the diversity, evolution and functional success of distinct molecular pathways. Mechanistic work will focus on selected mobile elements that confer resistance to last resort drugs and promiscuous gene carriers with high prevalence in health care. Bioinformatic quests will draw on recent (meta)genomic data to chart the clinical significance of molecular insights in situ. By bridging disciplines, I want to provide functionally annotated molecular movies of gene movement and explain how specific molecular strategies evolved to enable broad dissemination of resistance determinants. The insights gained in this research will provide in-depth knowledge on major AR transfer pathways and will have key implications for the development of novel intervention strategies and preventive measures aimed at reducing dissemination of drug resistance in bacteria.

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The information about "MARS" are provided by the European Opendata Portal: CORDIS opendata.

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