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e-MICROBe SIGNED

Energizing microbes with redox mediators for new bioproductions

Total Cost €

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EC-Contrib. €

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Partnership

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 e-MICROBe project word cloud

Explore the words cloud of the e-MICROBe project. It provides you a very rough idea of what is the project "e-MICROBe" about.

switch    act    metabolism    whereby    central    bioproduct    secreted    store    anodic    traits    cellular    fundamental    foundation    electrical    microbe    clarify    performance    bioprocesses    environmental    cathode    technique    electrochemistry    soluble    anode    engineer    independent    biotech    micro    culture    stability    microscopic    exchange    energy    utilizes    latter    underlying    re    anaerobic    consumption    aerobic    situ    mediator    microbial    broad    bioprocess    plug    observation    couple    electro    cathodic    mediators    steer    efficient    reaction    producing    respiration    thereby    portfolio    lay    employed    play    detrimental    generating    discharge    donor    bioelectrochemical    coupled    mechanism    electrons    co    electron    physiological    either    strains    shuttle    strategy    produces    acceptor    entirely    hosts    substances    generate    redox    generation    operation    innately    cell    inorganic    microorganisms    self    oxygen    reactor    hydrogen    autotrophic   

Project "e-MICROBe" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙991 €
 EC max contribution 1˙999˙991 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 1˙999˙991.00

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 Project objective

In many bioprocesses a broad bioproduct portfolio can currently only be obtained when microorganisms can access oxygen as an electron acceptor. For numerous target substances, however, oxygen is detrimental to product stability and the bioprocess operation. The central aim of e-MICROBe is to innately couple microbial metabolism and electrochemistry via a self-secreted soluble electron mediator to achieve efficient oxygen independent energy metabolism and to directly steer and control metabolism and product formation. This will require creating entirely new physiological traits for production and utilization of redox mediators to generate cellular energy. Thereby, mediators can either act as electron discharge shuttle to enable electro-respiration at an anode or they are employed as inorganic energy donor to deliver electrons from a cathode into the metabolism. We will clarify the underlying reaction pathways in known environmental microorganisms and re-engineer the energy metabolism of common biotech hosts. Thereby, we will switch cellular energy generation from aerobic respiration to anaerobic anodic electro-respiration or from hydrogen consumption as autotrophic electron donor to cathodic electron consumption. The latter process will provide a mechanism to store electrical energy in microbial products. For a new level of in situ insight into microbial energy metabolism, a novel micro-scale bioelectrochemical reactor coupled to microscopic observation and high performance analysis will be developed. With this technique two fundamental concepts for future mediator-based bioprocesses will be evaluated: An all-in-one strategy where one cell is generating the mediators and the targeted product as well as a co-culture system, whereby one cell produces the mediators and a partner cell utilizes them for electro-respiration and product formation. This concept will lay the foundation for a plug-and-play exchange of biotech strains in a mediator-producing co-culture system.

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The information about "E-MICROBE" are provided by the European Opendata Portal: CORDIS opendata.

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