Opendata, web and dolomites

ParkIFNAR SIGNED

Soluble IFNAR2 in Parkinson's disease and its role in the regulation of IFNβ in a neuroinflammatory context.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ParkIFNAR project word cloud

Explore the words cloud of the ParkIFNAR project. It provides you a very rough idea of what is the project "ParkIFNAR" about.

molecular    training    restoring    sifnar2    neurons    pds    context    regulatory    people    maintaining    protein    scientific    edge    benefit    fulfilling    controls    dysregulation    subunits    neuroinflammatory    ifnar1    pathology    reveal    found    lab    million    expertise    treatment    parkinsonian    hypnotise    proteostasis    pd    interactions    unknown    evidences    serum    msca    intrinsic    disorders    neuronal    essentially    receptor    cellular    annually    indicating    beta    mode    host    extremely    caused    remarkably    defective    membrane    levels    patients    function    laboratories    molecule    lower    mechanisms    alterations    cure    billion    expressed    discovered    decreased    career    family    plays    ifnar2    partly    mutation    ifnar    soluble    modulate    homeostasis    signalling    disturbed    interplay    motor    action    ifn    cutting    regulator    neuroinflammation    dopaminergic    13    mitochondrial    endogenous    mediated    interferons   

Project "ParkIFNAR" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-14   to  2022-09-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Parkinsonian disorders (PDs) affect more than 1.2 million people in Europe with an estimated cost of €13.9 billion annually and have no cure. PDs have long been characterized by decreased motor activity, which is caused by the loss of dopaminergic neurons. Several disturbed processes have been described such as proteostasis, mitochondrial function and neuroinflammation, but its molecular mechanisms and their interactions are essentially unknown. There are recent evidences of alterations in the interferons’ (IFN) signalling involved in the neuroinflammatory processes of PDs. The host lab discovered the essential role of IFNβ signalling in the neuronal homeostasis of PD. The IFNβ receptor (IFNAR) plays a key role in the control of IFNβ cellular responses. However, the regulatory mechanisms, at level of its membrane subunits IFNAR 1 and 2, and especially its soluble receptor sIFNAR2 have not been characterized in PD-associated neuroinflammatory context. Most remarkably, the host lab has also identified a new mutation in IFNAR1 associated with a family of PD patients, and I have found that PDs present lower serum levels of sIFNAR2 than controls indicating dysregulation in this pathway. Based on our findings, I hypnotise that a defective IFNβ-IFNAR signalling is associated with PD pathology and this could be partly mediated by the function of sIFNAR2 as this protein is able to modulate the endogenous IFNβ and interplay with membrane-expressed IFNAR1 or IFNAR2. Fulfilling the tasks of this proposal will have strong potential to reveal the mode of action of sIFNAR2, as IFNβ-IFNAR signalling regulator, and as a novel molecule with intrinsic activities in maintaining & restoring the neuronal homeostasis and therefore could identify novel targets for treatment of PD. Through this MSCA-IF I would benefit from a unique training and expertise in one of the most cutting-edge laboratories of the research proposed here, and it will impact extremely my future scientific career.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PARKIFNAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PARKIFNAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TeamUp (2020)

Understanding and improving team decision making in uncertain environments

Read More