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GlycoSpec SIGNED

Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoSpec project word cloud

Explore the words cloud of the GlycoSpec project. It provides you a very rough idea of what is the project "GlycoSpec" about.

oligosaccharides    extensive    tandem    structural    mass    dictates    assignments    theory    gain    erroneous    occurrence    almost    mechanistic    nature    functions    bond    spectroscopy    virtually    lived    prediction    rules    instrument    creates    automatable    largely    spectrometric    frequent    spectrometry    spectra    rearrangement    cationic    glycans    absolutely    oligosaccharide    intermediates    complicated    glycosciences    generally    unravel    proteomics    ing    oxocarbenium    isomers    synthetic    basis    tailor    diversity    mechanistically    stereochemistry    structure    synthesis    combination    sequencing    cold    probing    fragmentation    mechanisms    pursuit    glycosynthesis    fundamental    poorly    biological    central    ion    encode    accessible    species    glycosidic    equally    reactive    glycospec    reaction    building    initiate    chemical    successful    blocks    glycomics    bonds    assembly    mobility    techniques    reactions    outcome    difficult    glycan   

Project "GlycoSpec" data sheet

The following table provides information about the project.

Coordinator
FREIE UNIVERSITAET BERLIN 

Organization address
address: KAISERSWERTHER STRASSE 16-18
city: BERLIN
postcode: 14195
website: www.fu-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙642˙850 €
 EC max contribution 2˙642˙850 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2025-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FREIE UNIVERSITAET BERLIN DE (BERLIN) coordinator 1˙705˙350.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 937˙500.00

Map

 Project objective

Oligosaccharides or glycans are essential in nature and central participants in virtually every biological process. The extensive structural diversity enables glycans to encode rich information in biological functions; however, it also creates major challenges in almost all aspects of the glycosciences. The synthetic formation of glycosidic bonds during glycan assembly for example, is mechanistically still not fully understood. This is largely a result of highly-reactive, but short-lived oxocarbenium ion intermediates, which are difficult to study using established techniques. However, the structure of these intermediates dictates the stereochemistry of the resulting glycosidic bond, the control of which is absolutely crucial for a successful synthesis. An equally important aspect is the sequencing of glycans, which is generally complicated by the frequent occurrence of isomers. This is further complicated by poorly understood rearrangement reactions during mass spectrometric analysis, which often lead to erroneous structural assignments. Here as well, cationic intermediates are the key species that determine the outcome of the rearrangement. The aim of GlycoSpec is to unravel fundamental aspects of oligosaccharide reaction and fragmentation mechanisms by probing cationic glycan intermediates. To do so, a unique combination of instrument and method development (ion mobility-mass spectrometry and cold-ion spectroscopy), chemical synthesis and theory will be used. The gain in mechanistic understanding will provide the basis to tailor building blocks and reaction conditions and is expected to lead to a major advancement in glycosynthesis. The mechanistic understanding of fragmentation reactions will furthermore lead to general rules for the prediction of tandem mass spectra. Just like in the early years of proteomics, this will make the technology automatable and accessible for broader applications. Therefore, GlycoSpec will help to initiate the pursuit of glycomics.

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The information about "GLYCOSPEC" are provided by the European Opendata Portal: CORDIS opendata.

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