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BMPARK SIGNED

Development of BMP2 Neurotrophic Therapy for Parkinson’s Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BMPARK project word cloud

Explore the words cloud of the BMPARK project. It provides you a very rough idea of what is the project "BMPARK" about.

bmp2    career    function    lewy    molecular    projected    century    extensive    inclusions    disease    region    dopaminergic    neuropathological    double    scientific    million    dopamine    maturity    signalling    plans    date    investigation    accumulation    alpha    multidisciplinary    professional    neurite    trials    societal    relevance    demographic    morphogenetic    model    efficacy    transgene    hallmarks    protein    synuclein    therapy    pd    paralleled    people    brain    modifying    parkinson    context    economy    transformative    mechanism    substantia    bodies    me    13    therapies    total    predominantly    annum    motor    aging    nigra    bone    midbrain    clinical    rat    billion    communication    intensive    viral    progressive    highlight    despite    stakeholders    socioeconomic    axons    contribution    independence    worldwide    protect    bmp    degeneration    levels    half    training    neuroprotective    intraneuronal    consist    neurons    2030    neurotrophic    individuals    neurodegenerative    direct    vectors   

Project "BMPARK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 184˙590.00

Map

 Project objective

Parkinson’s Disease (PD) is a progressive neurodegenerative disease. PD affects more than 6 million people worldwide while 1.2 million people have PD in Europe. For the European economy PD has a total socioeconomic cost of €13.9 billion per annum. With the aging demographic the number of individuals affects by PD are projected to double by 2030 highlight the need for disease modifying therapies. The neuropathological hallmarks of PD are the progressive loss of dopaminergic neurons in a region of the brain known as the substantia nigra in the midbrain, and the accumulation of intraneuronal inclusions called Lewy bodies and lewy neurite that consist predominantly of a protein called α-synuclein. Despite over half a century of investigation, there is no disease modifying therapy for PD. I propose that a protein called bone morphogenetic protein (BMP)2 can protect midbrain dopaminergic neurons in the PD brain. BMP2 is distinct from other neurotrophic factors used in the clinical trials to date in that it has a different signalling mechanism that can be targeted to protect dopaminergic neurons. Here I will assess the neuroprotective efficacy of viral vectors carrying the BMP2 transgene in the rat α-synuclein model of PD. I will determine if this molecular therapy can protect dopamine neurons and their axons against α-synuclein induced degeneration to maintain brain dopamine levels and improve motor function. To do this, I will use a multidisciplinary approach which will be paralleled by intensive training and career development opportunities to enable me to make a transformative contribution to knowledge and to achieve professional maturity and independence. In this way, this work has direct relevance for the future development of neurotrophic factors for clinical use in PD and the extensive dissemination and communication plans to target all stakeholders will ensure both societal and scientific impact in an European context and also for individuals with PD.

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The information about "BMPARK" are provided by the European Opendata Portal: CORDIS opendata.

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