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BMPARK SIGNED

Development of BMP2 Neurotrophic Therapy for Parkinson’s Disease

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 BMPARK project word cloud

Explore the words cloud of the BMPARK project. It provides you a very rough idea of what is the project "BMPARK" about.

neuropathological    levels    degeneration    dopaminergic    me    investigation    despite    parkinson    economy    therapies    direct    brain    bone    hallmarks    morphogenetic    consist    efficacy    accumulation    highlight    function    maturity    vectors    context    alpha    inclusions    training    century    clinical    region    signalling    dopamine    neurons    extensive    socioeconomic    demographic    worldwide    transformative    relevance    neuroprotective    lewy    contribution    annum    midbrain    aging    individuals    societal    molecular    therapy    professional    stakeholders    people    scientific    billion    substantia    protect    projected    mechanism    model    paralleled    multidisciplinary    axons    date    nigra    disease    million    protein    intensive    13    modifying    motor    neurodegenerative    predominantly    trials    total    progressive    synuclein    2030    plans    bmp2    bmp    independence    double    neurotrophic    intraneuronal    career    pd    transgene    rat    viral    neurite    communication    bodies    half   

Project "BMPARK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 184˙590.00

Map

 Project objective

Parkinson’s Disease (PD) is a progressive neurodegenerative disease. PD affects more than 6 million people worldwide while 1.2 million people have PD in Europe. For the European economy PD has a total socioeconomic cost of €13.9 billion per annum. With the aging demographic the number of individuals affects by PD are projected to double by 2030 highlight the need for disease modifying therapies. The neuropathological hallmarks of PD are the progressive loss of dopaminergic neurons in a region of the brain known as the substantia nigra in the midbrain, and the accumulation of intraneuronal inclusions called Lewy bodies and lewy neurite that consist predominantly of a protein called α-synuclein. Despite over half a century of investigation, there is no disease modifying therapy for PD. I propose that a protein called bone morphogenetic protein (BMP)2 can protect midbrain dopaminergic neurons in the PD brain. BMP2 is distinct from other neurotrophic factors used in the clinical trials to date in that it has a different signalling mechanism that can be targeted to protect dopaminergic neurons. Here I will assess the neuroprotective efficacy of viral vectors carrying the BMP2 transgene in the rat α-synuclein model of PD. I will determine if this molecular therapy can protect dopamine neurons and their axons against α-synuclein induced degeneration to maintain brain dopamine levels and improve motor function. To do this, I will use a multidisciplinary approach which will be paralleled by intensive training and career development opportunities to enable me to make a transformative contribution to knowledge and to achieve professional maturity and independence. In this way, this work has direct relevance for the future development of neurotrophic factors for clinical use in PD and the extensive dissemination and communication plans to target all stakeholders will ensure both societal and scientific impact in an European context and also for individuals with PD.

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The information about "BMPARK" are provided by the European Opendata Portal: CORDIS opendata.

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