Opendata, web and dolomites


Redefining Tsetse symbiont bacteria: A Trojan horse against Trypanosome transmission

Total Cost €


EC-Contrib. €






 Trojan project word cloud

Explore the words cloud of the Trojan project. It provides you a very rough idea of what is the project "Trojan" about.

domesticated    fusion    reduce    molecular    biology    kill    therapeutic    university    entomology    transmission    causes    claim    microbiology    endosymbionts    animals    vivo    disease    skills    conceptual    flies    historic    sickness    france    interference    solid    competence    fly    proteins    stability    complementary    symbionts    innovative    promoters    nagana    scourge    tsetse    sleeping    groningen    eliminate    secretion    humans    antimicrobial    trypanosoma    advantage    fighting    drastically    characterization    evaluation    agriculture    parasite    worst    groups    infected    methodology    time    identification    idea    sodalis    national    assays    health    expertise    responsible    french    blocking    drug    fluorescent    insecticidal    trypanosomiasis    methodological    overexpressed    rna    sp    vector    trypanosome    continent    expression    paratransgenesis    netherlands    inherency    progeny    poverty    interaction    african    avoids    peptides    heterologous    sustainable    active    parasitology   

Project "Trojan" data sheet

The following table provides information about the project.


Organization address
address: Broerstraat 5
postcode: 9712CP

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

African trypanosomiasis has been a historic scourge on the African continent and one of the major causes of poverty. It is responsible for sleeping sickness in humans and it avoids the development of agriculture based on domesticated animals where it causes Nagana. It is a neglected disease with the worst drug control according to WHO. In this project, I propose a conceptual change in the therapeutic approach against Trypanosoma sp., being the goal of the proposal to eliminate the parasite in its vector, the tsetse fly, thus fighting both, sleeping sickness and Nagana. Taking advantage of the current methodological advances, the claim of this innovative proposal is the design of a new expression system to reduce or eliminate the vector competence, using for it one of the endosymbionts of the fly, Sodalis sp. The development of this idea involves a work of entomology, microbiology, parasitology and molecular biology. For this study, 2 research groups with solid and complementary expertise and skills are required: The French National Research Institute for Sustainable Development (France) and the University of Groningen (The Netherlands). The methodology implemented in this project will be: (i) characterization of proteins secretion pathways in Sodalis for heterologous expression of peptides, (ii) identification of promoters overexpressed in Sodalis upon interaction with Trypanosoma, and their characterization by fusion to fluorescent proteins, iii) paratransgenesis assays in flies and evaluation of the in vivo activity in infected and non-infected flies, stability across time and inherency to progeny, iv) analysis of the vector competence, using the new expression system by the production of antimicrobial peptides active against Trypanosoma, production of insecticidal peptides to kill the flies infected and RNA interference with the fly/symbionts. Blocking parasite transmission, we will contribute to drastically reduce the impact of trypanosome on African health.

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The information about "TROJAN" are provided by the European Opendata Portal: CORDIS opendata.

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