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Trojan SIGNED

Redefining Tsetse symbiont bacteria: A Trojan horse against Trypanosome transmission

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Trojan project word cloud

Explore the words cloud of the Trojan project. It provides you a very rough idea of what is the project "Trojan" about.

innovative    infected    methodology    endosymbionts    causes    symbionts    solid    stability    therapeutic    animals    continent    entomology    university    secretion    drastically    skills    fusion    idea    trypanosoma    national    worst    heterologous    inherency    trypanosomiasis    sustainable    historic    vector    advantage    fighting    microbiology    drug    nagana    fly    biology    identification    sleeping    humans    france    trypanosome    blocking    time    netherlands    french    disease    transmission    active    characterization    interaction    health    fluorescent    claim    peptides    reduce    poverty    parasitology    scourge    avoids    competence    expression    responsible    parasite    antimicrobial    eliminate    flies    paratransgenesis    evaluation    sickness    promoters    domesticated    proteins    tsetse    interference    progeny    agriculture    sp    complementary    groningen    overexpressed    vivo    kill    assays    expertise    sodalis    molecular    methodological    insecticidal    conceptual    rna    groups    african   

Project "Trojan" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 187˙572.00

Map

 Project objective

African trypanosomiasis has been a historic scourge on the African continent and one of the major causes of poverty. It is responsible for sleeping sickness in humans and it avoids the development of agriculture based on domesticated animals where it causes Nagana. It is a neglected disease with the worst drug control according to WHO. In this project, I propose a conceptual change in the therapeutic approach against Trypanosoma sp., being the goal of the proposal to eliminate the parasite in its vector, the tsetse fly, thus fighting both, sleeping sickness and Nagana. Taking advantage of the current methodological advances, the claim of this innovative proposal is the design of a new expression system to reduce or eliminate the vector competence, using for it one of the endosymbionts of the fly, Sodalis sp. The development of this idea involves a work of entomology, microbiology, parasitology and molecular biology. For this study, 2 research groups with solid and complementary expertise and skills are required: The French National Research Institute for Sustainable Development (France) and the University of Groningen (The Netherlands). The methodology implemented in this project will be: (i) characterization of proteins secretion pathways in Sodalis for heterologous expression of peptides, (ii) identification of promoters overexpressed in Sodalis upon interaction with Trypanosoma, and their characterization by fusion to fluorescent proteins, iii) paratransgenesis assays in flies and evaluation of the in vivo activity in infected and non-infected flies, stability across time and inherency to progeny, iv) analysis of the vector competence, using the new expression system by the production of antimicrobial peptides active against Trypanosoma, production of insecticidal peptides to kill the flies infected and RNA interference with the fly/symbionts. Blocking parasite transmission, we will contribute to drastically reduce the impact of trypanosome on African health.

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The information about "TROJAN" are provided by the European Opendata Portal: CORDIS opendata.

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