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hyP5 SIGNED

Adopting orphan pumps: Structural and functional characterization of P5-ATPases

Total Cost €

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EC-Contrib. €

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Partnership

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 hyP5 project word cloud

Explore the words cloud of the hyP5 project. It provides you a very rough idea of what is the project "hyP5" about.

cell    cryo    disease    basis    phd    na    astonishingly    little    ray    atp13a1    relationships    microscopy    profound    strategies    spectrometry    atp13a2    host    bound    hek    disorders    assays    elucidate    mass    membrane    subsequently    native    human    proteins    diseases    interaction    atpase    structure    eukaryotes    traits    yeasts    catalytic    mechanisms    expand    last    molecular    identification    severe    ions    onset    decades    guide    electron    parkinsonism    expressed    single    structures    despite    discovery    malfunctions    cells    particle    spf1p    familial    substrates    autism    postdoc    drug    conserved    phenotypical    ca2    neurodegenerative    functional    function    cellular    biology    pumps    ypk9p    mutational    subjects    belong    superfamily    biotechnologically    purified    ion    cofactors    cognitive    yeast    treatments    pursue    park9    reveal    3d    serve    transporters    crystallography    lipids    atpases    em    medicine    actual    neurological    wish    characterization    network    physiological    language    structural    investigations    substrate    orthologues    p5   

Project "hyP5" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 219˙312.00

Map

 Project objective

P5-ATPases are conserved in all eukaryotes and malfunctions in human are associated with severe neurological diseases, such as familial early-onset parkinsonism and autism/language disorders, and with phenotypical traits in yeasts. They belong to the P-type ATPase superfamily, which encompass a range of essential membrane transporters for ions and lipids. Ion pumps such as Na,K-ATPase and Ca2-ATPase have been studied in great detail during the last decades. However, astonishingly little is known about the P5-ATPases and their actual function, despite their physiological importance in all eukaryotes. The current proposal focuses on substrate identification and structural characterization of P5-ATPases, as well as investigations of their cellular interaction network. Human P5-ATPases (ATP13A1 through 5, ATP13A2 also known as PARK9) and the yeast orthologues Spf1p and Ypk9p will be subjects of this study. Target proteins will be expressed in their native host (yeast or HEK cells) and subsequently purified and used for activity assays, structural studies, and identification of interaction partners. Native mass spectrometry will identify bound substrates and cofactors, and activity studies will elucidate structure-function relationships. 3D-structures obtained by single-particle cryo-electron microscopy (cryo-EM) and/or X-ray crystallography will reveal catalytic mechanisms and mutational effects. Structural and functional characterization of P5-ATPases can therefore serve as a basis for understanding molecular mechanisms of e.g. neurodegenerative and cognitive disorders and guide novel strategies in disease treatments and drug discovery. Using my profound experience from my PhD with crystallography of biotechnologically relevant proteins, I wish to pursue a postdoc focused on membrane proteins with a strong potential in molecular medicine and to expand my knowledge of methods in structural biology and molecular cell biology, in particular cryo-EM.

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The information about "HYP5" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-09-25 20:31:28) correctly updated