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UCARE SIGNED

Uncovering the epigenetic signature of female-specifiC biological networks and key driver genes of coronary ArteRy diseasE

Total Cost €

0

EC-Contrib. €

0

Partnership

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 UCARE project word cloud

Explore the words cloud of the UCARE project. It provides you a very rough idea of what is the project "UCARE" about.

atherosclerotic    42    hospitalizations    plaque    pooling    missed    biobank    cad    lagging    artery    gene    causes    trials    individual    differences    tissues    powered    diagnostic    ruptured    data    underrepresentation    erosion    evident    mostly    efforts    coronary    utilize    worrying    corresponds    unravel    analyze    expression    systemically    rupture    thrombus    younger    free    expressed    diseased    diagnostics    patterns    translated    recognition    profiles    tissue    deaths    intact    trend    convincingly    cell    sexes    cardiovascular    51    women    ages    endothelial    closing    pathophysiology    networks    diagnoses    regulatory    genes    biology    gap    sex    dna    single    player    female    delayed    epigenetic    clinical    whereas    contributed    methylation    plasma    clinically    gradually    plaques    disease    men    shown    human    suffer    underlying    ucare    mechanism    move    refers    signatures    aid    group    samples    cells    diagnosis    vascular   

Project "UCARE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙999˙979 €
 EC max contribution 1˙999˙979 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-08-31   to  2025-08-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙999˙979.00

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 Project objective

Cardiovascular disease causes 51% of deaths in women and 42% of deaths in men in Europe. Women are contributing mostly to the worrying trend of increases in hospitalizations for coronary artery disease (CAD) at younger ages. Missed and delayed diagnoses in women are more common than in men, as the pathophysiology of CAD in women is different than in men. Men often have atherosclerotic plaque rupture as underlying mechanism for CAD whereas women more often suffer from plaque erosion. Plaque erosion refers to thrombus formation on top of an intact non-ruptured plaque in the coronary artery.

Early recognition of plaque erosion will, therefore, specifically aid in the diagnosis of CAD in women. However, knowledge on CAD and plaque erosion in women is lagging behind. This is due to the underrepresentation of women in clinical trials for CAD and biobank studies. This gap is now only gradually being recognized in research, but not yet fully addressed as pooling of data from both sexes is still common practice. My research efforts have convincingly contributed to the awareness that sex differences in human diseased vascular tissue are relevant. With my group I have shown that sex differences are specifically evident in regulatory gene networks and key player genes for CAD. This also corresponds with sex-specific epigenetic signatures of atherosclerotic plaques, and human endothelial gene expression patterns.

In UCARE, I propose to utilize vascular tissues and plaque samples from well-powered studies to analyze these by sex to a single-cell level. This approach will identify female-specific key player genes in individual cells of plaques and unravel clinically relevant female-specific biology of CAD and plaque erosion. These findings will be translated to systemically expressed DNA methylation profiles in cell free DNA in plasma to move towards early diagnostics. This is a necessary and challenging step towards closing the diagnostic gap between men and women.

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The information about "UCARE" are provided by the European Opendata Portal: CORDIS opendata.

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