Explore the words cloud of the PyroSuL project. It provides you a very rough idea of what is the project "PyroSuL" about.
The following table provides information about the project.
UNIVERSITY OF EAST ANGLIA
|Coordinator Country||United Kingdom [UK]|
|Total cost||212˙933 €|
|EC max contribution||212˙933 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2021-01-01 to 2022-12-31|
Take a look of project's partnership.
|1||UNIVERSITY OF EAST ANGLIA||UK (NORWICH)||coordinator||212˙933.00|
PyroSuL (Pyrophosphate Surrogates with Low polarity as part of glycosyltransferase ligands) is a project focused on the development of synthetic building blocks acting as surrogates for the pyrophosphate moiety in glycosyltransferase inhibitors. The final aim of this project is obtaining less polar ligands and inhibitors able to permeate across cellular membranes, which is the bottleneck for these inhibitors to have in vivo biological application. Through structure-based design, new surrogates will be explored. Interaction studies will be carried out through firstly computational approaches, and spectroscopic (nuclear magnetic resonance) and spectrometric (mass spectrometry) techniques will be employed. Surrogates showing promising affinity with the pyrophosphate recognition zone will be synthetically incorporated to substrate-like compounds, bearing a nucleoside and a carbohydrate or mimic. Final derivatives are supposed to show good protein affinities and membrane permeability properties.
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The information about "PYROSUL" are provided by the European Opendata Portal: CORDIS opendata.
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