Opendata, web and dolomites

ANEUPLOIDY SIGNED

Molecular origins of aneuploidies in healthy and diseased human tissues

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "ANEUPLOIDY" data sheet

The following table provides information about the project.

Coordinator
RUDER BOSKOVIC INSTITUTE 

Organization address
address: Bijenicka cesta 54
city: ZAGREB
postcode: 10000
website: www.irb.hr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Croatia [HR]
 Total cost 9˙999˙750 €
 EC max contribution 9˙999˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2026-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUDER BOSKOVIC INSTITUTE HR (ZAGREB) coordinator 3˙833˙375.00
2    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 3˙489˙250.00
3    FACULTY OF SCIENCE UNIVERSITY OF ZAGREB HR (ZAGREB) participant 1˙499˙625.00
4    MASSACHUSETTS INSTITUTE OF TECHNOLOGY US (CAMBRIDGE) participant 1˙177˙500.00

Map

 Project objective

Chromosome segregation errors cause aneuploidy, a state of karyotype imbalance that accelerates tumor formation and impairs embryonic development. Even though mitotic errors have been studied extensively in cell cultures, the mechanisms generating various errors, their propagation and effects on genome integrity are not well understood. Moreover, very little is known about mitotic errors in complex tissues. The main goal of this project is to uncover the molecular origins of mitotic errors and their contribution to karyotype aberrations in healthy and diseased tissues. To achieve our goal, we have assembled an interdisciplinary team of experts in molecular and cell biology, cell biophysics, chromosomal instability in cancer, and theoretical physics. Our team will introduce novel approaches to study aneuploidy (superresolution microscopy, optogenetics, laser ablation, single cell karyotype sequencing) and apply them to state-of-the-art tissue cultures (mammalian organoids and tumoroids). In close collaboration, Tolić will establish assays to detect and quantify error types in cells, and Kops and Amon will use the assays on various healthy and cancer tissues. Tolić and Kops will uncover the molecular origins of errors, their propagation and impact on genome integrity, while Amon will lead the investigation of the mechanisms that ensure high chromosome segregation fidelity in healthy tissues. Interwoven in these collaborations are the efforts of Pavin, who will develop a theoretical model to describe the origin of errors and to quantitatively link chromosome segregation fidelity in single cells and tissues. Model and experiment will continuously inspire each other, to achieve deep understanding of how mitotic errors arise, how they propagate and how they impact on cell populations. Thus, the extensive sets of expertise present in our team will be combined and expanded with novel technologies to tackle the big challenge of the origins of aneuploidy in humans.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANEUPLOIDY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ANEUPLOIDY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

TOROS (2019)

A Theory-Oriented Real-Time Operating System for Temporally Sound Cyber-Physical Systems

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More  

sociOlfa (2020)

Learning from social scents: from territory to identity

Read More