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Ctrl-BBB SIGNED

Blood-brain barrier: from molecular mechanisms to intervention strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Ctrl-BBB project word cloud

Explore the words cloud of the Ctrl-BBB project. It provides you a very rough idea of what is the project "Ctrl-BBB" about.

neurodegeneration    experiments    disease    strategies    neuroprotective    synergistic    transformative    genetically    consequently    tissues    pioneer    zebrafish    treat    stroke    cellular    protection    pace    unprecedented    metabolic    resides    barrier    therapeutic    diseases    instead    brain    recapitulated    communication    endothelial    transit    disorders    invasive    powerful    instruction    dysfunction    adaptations    parallel    molecular    cns    ctrl    conserved    empowering    era    sclerosis    ideally    health    shedding    hardwired    miniature    laboratory    stringently    qualifies    culture    healing    constitute    regulation    genetic    unifying    spectrum    cells    cerebrovascular    endowed    ecs    cerebrovasculature    neurovascular    pivotal    validated    orchestrate    complexity    hallmark    circulatory    permeability    blood    homeostasis    undoubtedly    obstacle    suited    bbb    avenue    model    transparent    alternative    cell    drug    accordingly    ongoing    mechanistic    human    communications    place    multiple    normoxia    components    yield    function    mouse    light    urgent   

Project "Ctrl-BBB" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙286˙542 €
 EC max contribution 2˙286˙542 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2025-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 2˙286˙542.00

Map

 Project objective

Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is therefore emerging as a powerful therapeutic avenue for a spectrum of human CNS disorders. In addition, through its neuroprotective function, the BBB represents the main obstacle for CNS drug delivery. There is consequently an urgent need to identify methods to control BBB in health and disease. Of pivotal importance, BBB is not genetically hardwired, but instead results from ongoing neurovascular communications taking place between the ECs and the other components of the neurovascular unit. Shedding light on these communications, and raising our understanding to the mechanistic level will undoubtedly yield transformative therapeutic strategies for human brain disorders. A key obstacle in the study of BBB permeability resides in its complex regulation across cells and tissues. This complexity cannot be recapitulated in cell culture experiments. Our laboratory has recently identified and validated the transparent zebrafish as ideally suited to facilitate these studies, by empowering non-invasive genetic analyses of BBB function under normoxia. Together with a conserved BBB genetic instruction program, the zebrafish cerebrovasculature qualifies as a an alternative “miniature BBB model” where neurovascular communication can be studied at an unprecedented pace. Ctrl-BBB will pioneer synergistic approaches between the zebrafish and the mouse model, to bring BBB research in the era of highly parallel genetic approaches and BBB-focused therapeutic strategies for brain disorders.

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The information about "CTRL-BBB" are provided by the European Opendata Portal: CORDIS opendata.

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