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Ctrl-BBB SIGNED

Blood-brain barrier: from molecular mechanisms to intervention strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Ctrl-BBB project word cloud

Explore the words cloud of the Ctrl-BBB project. It provides you a very rough idea of what is the project "Ctrl-BBB" about.

pivotal    spectrum    laboratory    hallmark    genetic    model    barrier    transformative    mechanistic    adaptations    dysfunction    regulation    invasive    suited    brain    parallel    communication    consequently    cerebrovasculature    communications    health    cerebrovascular    drug    healing    sclerosis    cells    instruction    function    disorders    resides    avenue    unifying    culture    disease    complexity    constitute    diseases    homeostasis    endothelial    neurodegeneration    hardwired    cellular    empowering    synergistic    shedding    therapeutic    human    orchestrate    instead    blood    molecular    protection    mouse    pace    validated    treat    pioneer    qualifies    place    cns    normoxia    transparent    ongoing    circulatory    stroke    obstacle    undoubtedly    era    multiple    components    ideally    light    yield    permeability    zebrafish    transit    alternative    endowed    powerful    neurovascular    miniature    conserved    urgent    cell    ctrl    recapitulated    tissues    experiments    unprecedented    bbb    accordingly    neuroprotective    ecs    genetically    strategies    stringently    metabolic   

Project "Ctrl-BBB" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙286˙542 €
 EC max contribution 2˙286˙542 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2025-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 2˙286˙542.00

Map

 Project objective

Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is therefore emerging as a powerful therapeutic avenue for a spectrum of human CNS disorders. In addition, through its neuroprotective function, the BBB represents the main obstacle for CNS drug delivery. There is consequently an urgent need to identify methods to control BBB in health and disease. Of pivotal importance, BBB is not genetically hardwired, but instead results from ongoing neurovascular communications taking place between the ECs and the other components of the neurovascular unit. Shedding light on these communications, and raising our understanding to the mechanistic level will undoubtedly yield transformative therapeutic strategies for human brain disorders. A key obstacle in the study of BBB permeability resides in its complex regulation across cells and tissues. This complexity cannot be recapitulated in cell culture experiments. Our laboratory has recently identified and validated the transparent zebrafish as ideally suited to facilitate these studies, by empowering non-invasive genetic analyses of BBB function under normoxia. Together with a conserved BBB genetic instruction program, the zebrafish cerebrovasculature qualifies as a an alternative “miniature BBB model” where neurovascular communication can be studied at an unprecedented pace. Ctrl-BBB will pioneer synergistic approaches between the zebrafish and the mouse model, to bring BBB research in the era of highly parallel genetic approaches and BBB-focused therapeutic strategies for brain disorders.

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The information about "CTRL-BBB" are provided by the European Opendata Portal: CORDIS opendata.

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