Opendata, web and dolomites

Ctrl-BBB SIGNED

Blood-brain barrier: from molecular mechanisms to intervention strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Ctrl-BBB project word cloud

Explore the words cloud of the Ctrl-BBB project. It provides you a very rough idea of what is the project "Ctrl-BBB" about.

sclerosis    invasive    avenue    pace    bbb    yield    health    alternative    diseases    parallel    permeability    cerebrovasculature    ecs    cellular    hallmark    stroke    dysfunction    instruction    genetic    neuroprotective    ctrl    instead    unprecedented    disease    place    miniature    cell    treat    cerebrovascular    light    zebrafish    culture    conserved    transformative    urgent    communication    genetically    protection    validated    hardwired    multiple    transit    endowed    mouse    normoxia    powerful    molecular    obstacle    drug    model    laboratory    neurodegeneration    experiments    adaptations    therapeutic    cells    orchestrate    undoubtedly    ongoing    strategies    pioneer    regulation    empowering    barrier    synergistic    unifying    constitute    tissues    ideally    endothelial    mechanistic    neurovascular    era    stringently    healing    cns    pivotal    resides    metabolic    homeostasis    qualifies    components    shedding    communications    brain    human    function    accordingly    consequently    suited    complexity    transparent    blood    spectrum    recapitulated    circulatory    disorders   

Project "Ctrl-BBB" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙286˙542 €
 EC max contribution 2˙286˙542 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2025-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 2˙286˙542.00

Map

 Project objective

Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is therefore emerging as a powerful therapeutic avenue for a spectrum of human CNS disorders. In addition, through its neuroprotective function, the BBB represents the main obstacle for CNS drug delivery. There is consequently an urgent need to identify methods to control BBB in health and disease. Of pivotal importance, BBB is not genetically hardwired, but instead results from ongoing neurovascular communications taking place between the ECs and the other components of the neurovascular unit. Shedding light on these communications, and raising our understanding to the mechanistic level will undoubtedly yield transformative therapeutic strategies for human brain disorders. A key obstacle in the study of BBB permeability resides in its complex regulation across cells and tissues. This complexity cannot be recapitulated in cell culture experiments. Our laboratory has recently identified and validated the transparent zebrafish as ideally suited to facilitate these studies, by empowering non-invasive genetic analyses of BBB function under normoxia. Together with a conserved BBB genetic instruction program, the zebrafish cerebrovasculature qualifies as a an alternative “miniature BBB model” where neurovascular communication can be studied at an unprecedented pace. Ctrl-BBB will pioneer synergistic approaches between the zebrafish and the mouse model, to bring BBB research in the era of highly parallel genetic approaches and BBB-focused therapeutic strategies for brain disorders.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CTRL-BBB" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CTRL-BBB" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More