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Ctrl-BBB SIGNED

Blood-brain barrier: from molecular mechanisms to intervention strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Ctrl-BBB project word cloud

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light    mouse    ongoing    constitute    dysfunction    multiple    suited    model    genetically    endothelial    stringently    disease    culture    avenue    communications    neurodegeneration    cns    pioneer    homeostasis    strategies    validated    laboratory    genetic    cerebrovascular    disorders    hardwired    obstacle    recapitulated    neuroprotective    accordingly    cellular    ctrl    conserved    synergistic    cells    cerebrovasculature    components    protection    zebrafish    communication    pace    stroke    era    bbb    therapeutic    metabolic    neurovascular    permeability    mechanistic    complexity    sclerosis    transformative    miniature    ecs    parallel    hallmark    qualifies    orchestrate    empowering    place    function    urgent    cell    unifying    health    blood    shedding    treat    consequently    molecular    circulatory    transparent    adaptations    regulation    resides    alternative    unprecedented    instruction    brain    drug    instead    human    ideally    spectrum    experiments    pivotal    healing    transit    normoxia    yield    invasive    diseases    barrier    endowed    undoubtedly    tissues    powerful   

Project "Ctrl-BBB" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙286˙542 €
 EC max contribution 2˙286˙542 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2025-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 2˙286˙542.00

Map

 Project objective

Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is therefore emerging as a powerful therapeutic avenue for a spectrum of human CNS disorders. In addition, through its neuroprotective function, the BBB represents the main obstacle for CNS drug delivery. There is consequently an urgent need to identify methods to control BBB in health and disease. Of pivotal importance, BBB is not genetically hardwired, but instead results from ongoing neurovascular communications taking place between the ECs and the other components of the neurovascular unit. Shedding light on these communications, and raising our understanding to the mechanistic level will undoubtedly yield transformative therapeutic strategies for human brain disorders. A key obstacle in the study of BBB permeability resides in its complex regulation across cells and tissues. This complexity cannot be recapitulated in cell culture experiments. Our laboratory has recently identified and validated the transparent zebrafish as ideally suited to facilitate these studies, by empowering non-invasive genetic analyses of BBB function under normoxia. Together with a conserved BBB genetic instruction program, the zebrafish cerebrovasculature qualifies as a an alternative “miniature BBB model” where neurovascular communication can be studied at an unprecedented pace. Ctrl-BBB will pioneer synergistic approaches between the zebrafish and the mouse model, to bring BBB research in the era of highly parallel genetic approaches and BBB-focused therapeutic strategies for brain disorders.

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The information about "CTRL-BBB" are provided by the European Opendata Portal: CORDIS opendata.

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