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VAMEAP SIGNED
Virulence Activities of the Metalloprotease Effector AVR-Pita from the rice blast fungus Magnaporthe oryzae
Total Cost €
0EC-Contrib. €
0Partnership
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0VAMEAP project word cloud
Explore the words cloud of the VAMEAP project. It provides you a very rough idea of what is the project "VAMEAP" about.
despite
found
oryzae
machinery
bridge
maintained
fitness
efficient
effector
blast
mechanisms
suggesting
proteins
protease
secreted
polymorphisms
biochemical
nothing
tool
screens
food
perform
life
magnapor
multidisciplinary
manipulate
plant
functional
virulence
vameap
avr
rice
metalloprotease
pathogens
resistance
molecular
powerful
natural
effectors
disease
rationally
cycle
diseases
strategies
pathogen
gather
fungal
constraint
combination
host
understand
sequence
crop
pressure
populations
causal
benefit
resilient
agent
protein
gap
interaction
survey
pita
biology
diversity
rely
underlying
Project "VAMEAP" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 184˙707 € |
| EC max contribution | 184˙707 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2021 |
| Duration (year-month-day) | from 2021-01-04 to 2023-01-03 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT | FR (PARIS CEDEX 07) | coordinator | 184˙707.00 |
Map
Project objective
Plant diseases are a major constraint on food production. To rationally design efficient and resilient disease control strategies, it is essential to understand the molecular mechanisms underlying pathogen virulence. Most pathogens rely on secreted proteins called effectors to manipulate the host machinery for their benefit and perform their life cycle. In VAMEAP, we propose to characterize the virulence activities of the metalloprotease effector AVR-Pita from Magnaporthe oryzae, the causal agent of rice blast disease. Despite a strong selection pressure against this effector, AVR-Pita is maintained in populations of the pathogen suggesting a crucial role for the fitness of M. oryzae. Yet, next to nothing is known about the virulence activities or host targets of AVR-Pita. Here we propose an ambitious combination of biochemical and functional approaches to bridge this knowledge gap. We will survey the natural diversity and sequence polymorphisms in AVR-Pita and investigate the impact of its loss on the fitness of M. oryzae. We will identify the virulence targets of AVR-Pita using protein-protein interaction screens and characterize the protease activity of this effector. Beyond the knowledge that this project will gather on AVR-Pita, it will also help to understand the biology of metalloprotease effectors commonly found in fungal pathogens. The multidisciplinary approach developed in this project will be a powerful tool to further understand fungal virulence and help design new resistance strategies to control fungal crop diseases.
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The information about "VAMEAP" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-04-19 18:45:24) correctly updated