Opendata, web and dolomites

EscaPI SIGNED

Exploring the non-genetic (i.e. ePIgenetic) mechanisms that contribute to therapy Escape in melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EscaPI project word cloud

Explore the words cloud of the EscaPI project. It provides you a very rough idea of what is the project "EscaPI" about.

barcoding    involvement    ensured    lab    mainly    thought    technologies    profiles    me    collaborations    predictive    jcm    sequencing    acquisition    multiplexed    epigenomics    acquired    view    cells    epigenomic    qualified    combining    develops    indicates    biomarkers    stochastic    genetic    manner    absence    anticipate    personal    drug    undergo    search    mrd    percentage    background    clinically    pool    scientist    vivo    disease    broaden    tracing    melanoma    data    staining    omics    patients    performing    single    minimal    context    unclear    evolution    epigenetic    underlying    depletion    anticancer    clinical    cell    lineage    combination    models    resolution    versus    drive    drugs    experts    tolerance    tolerant    dynamic    resistance    transition    phenotypes    experiments    reprogramming    computational    alterations    close    dna    heterogeneous    residual    advantage    skills    independent    subpopulation    date    epigenetics    achievements    mechanisms   

Project "EscaPI" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 178˙320.00

Map

 Project objective

Resistance to anticancer drugs, which often develops from a heterogeneous pool of drug-tolerant cells known as minimal residual disease (MRD), is thought to mainly occur through acquisition of genetic alterations. Emerging evidence indicates that drug resistance may also be acquired in absence of a genetic cause. It remains unclear, however, whether genetic versus non-genetic mechanisms of resistance are selected in a stochastic manner, and what are the epigenomics mechanisms underlying the transition from drug-tolerance to resistance. This project aims at identifying the drug-tolerant subpopulation(s) that drive non-genetic resistance by performing lineage tracing and depletion experiments in pre-clinical models. Taking advantage of up-to-date technologies combining in vivo barcoding and single-cell multi-omics approaches, this project aims to provide a dynamic and integrated view of the evolution of epigenomic profiles -at single-cell resolution- before, during and after acquisition of drug resistance phenotypes in a in vivo clinically-relevant context. A third objective of this proposal is to search for predictive biomarkers of non-genetic resistance and to assess the percentage of melanoma patients that undergo non-genetic resistance through combination of multiplexed staining and targeted DNA sequencing. The success of this project is ensured by my personal background in epigenetics and related data computational analysis, the achievements of the JCM lab in melanoma epigenetic reprogramming and the close collaborations with experts in single-cell multi-omics fields. I anticipate that my involvement in this project will broaden my skills and knowledge and help me become a high-qualified European independent scientist.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ESCAPI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ESCAPI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

ASSEMBLY (2019)

Advancing Synthethic Supramolecular chemical biology

Read More  

INSPiRE (2018)

The Influence of Information Search on Preference Formation and Choice

Read More