NETSIM

"An integrated study on three novel regulatory hubs in megakaryocytes and platelets, discovered as risk genes for myocardial infarction by a genome-wide association and platelet systems biology study"

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Edwards Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙851˙384 €
EC contributo	2˙851˙384 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-1-1-ITN
Funding Scheme	MC-ITN
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-09-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Edwards Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	coordinator	0.00
2	Academisch Medisch Centrum bij de Universiteit van Amsterdam  Organization address address: MEIBERGDREEF 9 city: AMSTERDAM postcode: 1105AZ contact info Nome: Margreet Cognome: Ruiter-Van Marle Email: send email Telefono: +31 20 566 5558 Fax: +31 20 691 5462	NL (AMSTERDAM)	participant	0.00
3	EUROPEAN MOLECULAR BIOLOGY LABORATORY  Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 contact info Titolo: Dr. Nome: Phil Cognome: Irving Email: send email Telefono: +49 6221 387 8239 Fax: +49 6221 387301	DE (HEIDELBERG)	participant	0.00
4	GENOME RESEARCH LIMITED  Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE contact info Titolo: Mr. Nome: David Cognome: Davison Email: send email Telefono: +44 1223 494937 Fax: +44 1223 494919	UK (LONDON)	participant	0.00
5	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Mr. Nome: Peter Cognome: Ilian Email: send email Telefono: +44 1223 330397 Fax: +44 1223 330365	UK (SWINDON)	participant	0.00
6	ROBERT BOSCH GMBH  Organization address address: Robert-Bosch Platz 1 city: GERLINGEN-SCHILLERHOEHE postcode: 70839 contact info Titolo: Mr. Nome: Carsten Cognome: Konradi Email: send email Telefono: +49 3032788 508 Fax: +49 3032788 224	DE (GERLINGEN-SCHILLERHOEHE)	participant	0.00
7	SYLVIA LAWRY CENTRE FOR MULTIPLE SCLEROSIS RESEARCH E.V.  Organization address address: HOHENLINDENER STRASSE 1 city: MUENCHEN postcode: 81677 contact info Titolo: Dr. Nome: Martin Cognome: Daumer Email: send email Telefono: +49 89 2060 269 50 Fax: +49 89 2060 269 51	DE (MUENCHEN)	participant	0.00
8	TECHNISCHE UNIVERSITAET MUENCHEN  Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 contact info Titolo: Prof. Nome: Nassir Cognome: Navab Email: send email Telefono: +49 89 289 17058 Fax: +49 89 289 17059	DE (MUENCHEN)	participant	0.00
9	TRIUM ANALYSIS ONLINE GMBH  Organization address address: HOHENLINDENER STRASSE 1 city: MUNCHEN postcode: 81677 contact info Titolo: Mr. Nome: Michael Cognome: Scholz Email: send email Telefono: +49 89 2060 26910 Fax: +49 89 2060 26911	DE (MUNCHEN)	participant	0.00
10	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Prof. Nome: Desmond Cognome: Fitzgerald Email: send email Telefono: +353 1 716 1285 Fax: +353 1 716 1216	IE (DUBLIN)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'The overarching objective of the ITN is to offer an intercalated study environment for young and talented researchers in the field of coronary artery disease (CAD) research. 12 PhD fellows operating in a unique training environment will work as a multi-disciplinary team to perform research spanning the full spectrum from basic to translational to bring novel inventions to the bedside. The fellows will be mentored by world-leading experts to shape a new generation of European leaders in biomedical science and overcome current fragmentation in Europe. The research is at the forefront of biomedical science because of the UK genome-wide association study in 2000 myocardial infarction (MI) patients and our EU-FP6 integrated projects Bloodomics and Cardiogenics. We will exploit our knowledge about the genetic architecture of MI to investigate the hypothesis whether sequence variation of genes encoding network hubs poses a greater risk for network destabilisation compared to genes encoding regular nodes. Focusing on three hub genes we postulate that genetic/bio-markers associated with hubs can be integrated in algorithms for MI/CAD risk prediction. Success will critically depend on new developments in computing, machine learning, pattern recognition and advanced data mining and statistical analysis. To have a free development path from basic discovery to health care improvement young scientists must be taught to cross the classic barriers between academic disciplines. We offer a timely and necessary alternative to Europe’s classic PhD programmes by providing a seamlessly integrated multi-disciplinary environment in an academic-private sector partnership free of boundaries. Our aim is a targeted strategy for prevention and treatment based on a better understanding of the genetic and molecular mechanism of disease. This will deliver major advances in public health and patient care, which can only be achieved if a new scientific cadre is developed.'

Introduzione (Teaser)

Young scientists have analysed genetic markers, biomarkers and lifestyle risk factors behind the formation of internal blood clots, a feature seen in cardiovascular disease.