CHIRAL-MOF

Development of New Chiral Adsorbents for Enantioselective Separations

Coordinatore	UNIVERSITY OF SURREY    more  Organization address address: Stag Hill city: GUILDFORD postcode: GU2 7XH contact info Titolo: Ms. Nome: Maria Cognome: Sega-Buhalis Email: send email Telefono: +44 1483 683498 Fax: +44 1483 689567
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	75˙000 €
EC contributo	75˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2014-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF SURREY  Organization address address: Stag Hill city: GUILDFORD postcode: GU2 7XH contact info Titolo: Ms. Nome: Maria Cognome: Sega-Buhalis Email: send email Telefono: +44 1483 683498 Fax: +44 1483 689567	UK (GUILDFORD)	coordinator	75˙000.00

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 Obiettivo del progetto (Objective)

'Separation of chiral molecules plays an important role in the production of a wide array of pharmaceuticals, agricultural chemicals, and other molecules. Often these separations are carried out using chromatography, but the materials used in chiral chromatography columns have a number of disadvantages. In particular, they exhibit low capacity and it is difficult to tailor them because of poor control over the molecular-level architecture where chiral binding occurs. To overcome these problems, this project will develop new metal-organic frameworks (MOFs) featuring well controlled chiral environments. MOFs are a new class of nanoporous materials synthesized in a building-block approach from metal nodes and organic linkers with great potential for separations, catalysis, and other applications.

The objectives of this multidisciplinary project are to • Develop and test the necessary tools for molecular simulation of adsorption of chiral molecules in MOFs • Use molecular modeling to guide the synthesis of new MOFs for targeted separation of some important racemic mixtures • Collaborate with synthetic chemists to demonstrate experimentally that MOFs can perform enantioselective separations and test the results from simulations against experiments • Gain a better understanding of chiral recognition and the factors that affect selectivity in chiral MOFs.

The proposed research will integrate solid state chemistry, adsorption fundamentals, and molecular modeling which forms the interface for achieving transformative advances in this field.'

Introduzione (Teaser)

Many important molecules exist in two nearly identical forms that have very different biological effects. EU-funded scientists investigated the use of novel supramolecular structures in separating the two.