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IN-Fo-trace-DG SIGNED

Role of GABAergic interneurons in the formation of new memory traces in the Dentate Gyrus ofbehaving mice

Total Cost €

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EC-Contrib. €

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Partnership

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 IN-Fo-trace-DG project word cloud

Explore the words cloud of the IN-Fo-trace-DG project. It provides you a very rough idea of what is the project "IN-Fo-trace-DG" about.

area    memories    structure    neuronal    disciplinary    processed    intensive    networks    theories    organisms    question    fo    inhibition    group    little    form    trace    interference    interneurons    dependent    gcs    mature    individual    acquisition    optogenetic    cell    difficult    granule    suggest    constraints    analyze    changing    neurons    born    patterns    recruitment    largely    recordings    visualize    virtual    excitation    photon    adapt    excitatory    first    memory    cellular    examine    associations    emerge    unknown    cells    output    plasticity    principal    interconnectivity    balance    space    traces    signals    mechanisms    environment    progress    spatial    population    learning    ins    modifications    tools    inhibitory    gabaergic    gyrus    dentate    made    fundamental    innovative    synapses    vivo    adult    cortical    populations    despite    dg    brain    insights    time    assembly    temporal    discrete    association    ones    differently    imaging    molecular   

Project "IN-Fo-trace-DG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙463˙693 €
 EC max contribution 2˙463˙693 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 2˙463˙693.00

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 Project objective

Despite intensive study in the past on the problem of how information is processed in the brain to enable individual organisms to adapt to their continuously changing environment, little progress has been made on how new similar but discrete memory traces emerge in neuronal networks during learning. Current theories suggest that experience-dependent modifications in excitation-inhibition balance enable a selected group of neurons to form a new cell association during learning which represent the new memory trace. It was further proposed that particularly GABAergic inhibitory interneurons (INs) have a large impact on population activity in neuronal networks by means of their inhibitory output synapses. However, how cell associations emerge in space and time and how INs may contribute to this process is still largely unknown. This complex topic was so far difficult to address due to technical constraints. IN-Fo-Trace-DG aims to address this fundamental question in the dentate gyrus (DG), a brain structure essential for the acquisition of similar but discrete new memories. Based on our detailed knowledge on DG’s cellular elements, their interconnectivity and our recently established molecular interference tools, we will first, visualize the spatial and temporal activity patterns of cell populations during spatial learning in a virtual-reality using 2-Photon imaging. Second, we will determine the role of IN recruitment and plasticity in assembly formation by optogenetic and molecular interference. Third, we will analyze changes in excitatory and inhibitory signals in granule cells (GCs), the principal cells in this brain area, and INs during learning using whole-cell recordings in vivo. Finally, we will examine whether adult-born GCs contribute differently to learning-associated population activity compared to mature ones in the adult DG. This innovative multi-disciplinary approach will provide new insights on the mechanisms of new memory formation in cortical networks.

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