Opendata, web and dolomites

IN-Fo-trace-DG SIGNED

Role of GABAergic interneurons in the formation of new memory traces in the Dentate Gyrus ofbehaving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IN-Fo-trace-DG project word cloud

Explore the words cloud of the IN-Fo-trace-DG project. It provides you a very rough idea of what is the project "IN-Fo-trace-DG" about.

gabaergic    group    examine    gyrus    cellular    discrete    intensive    principal    spatial    tools    traces    environment    associations    suggest    trace    imaging    granule    theories    constraints    fundamental    processed    interneurons    neuronal    made    balance    patterns    populations    disciplinary    memories    learning    emerge    inhibitory    optogenetic    changing    virtual    little    plasticity    synapses    molecular    association    dependent    question    neurons    organisms    output    mechanisms    adapt    born    area    dg    insights    progress    individual    ones    assembly    fo    interconnectivity    largely    modifications    signals    dentate    memory    interference    brain    unknown    cells    innovative    cell    excitation    time    temporal    networks    adult    analyze    ins    first    space    form    difficult    inhibition    recordings    despite    vivo    gcs    excitatory    population    mature    photon    differently    acquisition    recruitment    structure    cortical    visualize   

Project "IN-Fo-trace-DG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙463˙693 €
 EC max contribution 2˙463˙693 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 2˙463˙693.00

Map

 Project objective

Despite intensive study in the past on the problem of how information is processed in the brain to enable individual organisms to adapt to their continuously changing environment, little progress has been made on how new similar but discrete memory traces emerge in neuronal networks during learning. Current theories suggest that experience-dependent modifications in excitation-inhibition balance enable a selected group of neurons to form a new cell association during learning which represent the new memory trace. It was further proposed that particularly GABAergic inhibitory interneurons (INs) have a large impact on population activity in neuronal networks by means of their inhibitory output synapses. However, how cell associations emerge in space and time and how INs may contribute to this process is still largely unknown. This complex topic was so far difficult to address due to technical constraints. IN-Fo-Trace-DG aims to address this fundamental question in the dentate gyrus (DG), a brain structure essential for the acquisition of similar but discrete new memories. Based on our detailed knowledge on DG’s cellular elements, their interconnectivity and our recently established molecular interference tools, we will first, visualize the spatial and temporal activity patterns of cell populations during spatial learning in a virtual-reality using 2-Photon imaging. Second, we will determine the role of IN recruitment and plasticity in assembly formation by optogenetic and molecular interference. Third, we will analyze changes in excitatory and inhibitory signals in granule cells (GCs), the principal cells in this brain area, and INs during learning using whole-cell recordings in vivo. Finally, we will examine whether adult-born GCs contribute differently to learning-associated population activity compared to mature ones in the adult DG. This innovative multi-disciplinary approach will provide new insights on the mechanisms of new memory formation in cortical networks.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IN-FO-TRACE-DG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IN-FO-TRACE-DG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More