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UCUPA SIGNED

Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UCUPA project word cloud

Explore the words cloud of the UCUPA project. It provides you a very rough idea of what is the project "UCUPA" about.

host    caenorhabditis    cell    therapeutic    proteome    molecules    function    mechanism    microscopy    fewer    mutagenesis    reporter    techniques    transgenic    crispr    ageing    specialization    endoplasmic    genome    assays    arisen    model    activation    dysfunction    quality    ethical    accumulation    vertebrate    evolution    itself    specialized    aggregates    interventions    what    onset    xbp    track    disease    skills    organelles    defines    protein    age    editing    suggesting    screen    understand    1s    instrumental    unfolded    monitoring    transmembrane    translated    screening    alzheimer    elegans    proteostasis    reticulum    signalling    transcription    molecular    nematode    me    ire    er    proteins    lose    biological    functional    occurs    avenues    lifespan    independence    protect    shutdown    biogenesis    central    biology    disorders    animals    upr    models    declines    transference    weeks    advantages    properly    strains    prevent    sensor    implicated    folded    create    folding    monitor   

Project "UCUPA" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 212˙933.00

Map

 Project objective

What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorhabditis elegans as a model to understand age-related proteostasis dysfunction. C. elegans offer many advantages over the use of vertebrate models, such as its short lifespan of about two weeks, reduced costs, and fewer ethical issues. We will focus on the UPR pathway, as changes in this pathway have already been implicated in the ageing process itself and in the onset of age-related disorders, such as Alzheimer’s disease. We propose to use CRISPR genome editing to create C. elegans transgenic reporter strains that enable us to track the activity of different UPR signalling molecules using microscopy and molecular biology techniques. We will monitor two central steps of the IRE-1/XBP-1 UPR pathway (1) the activation of the transmembrane sensor protein IRE-1 and (2) the biogenesis of the transcription factor XBP-1s. After age-related changes have been identified, we will use mutagenesis-based screening assays to screen for novel interventions that prevent UPR pathway shutdown. This research will contribute to a better understanding of why ageing occurs, as well as suggesting new therapeutic avenues for age-related disorders. This proposal will also be instrumental for the development and transference of new skills between the host and the applicant that will lead me towards independence.

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The information about "UCUPA" are provided by the European Opendata Portal: CORDIS opendata.

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