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UCUPA SIGNED

Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 UCUPA project word cloud

Explore the words cloud of the UCUPA project. It provides you a very rough idea of what is the project "UCUPA" about.

specialization    molecular    advantages    upr    interventions    sensor    proteins    protein    cell    skills    track    evolution    lifespan    independence    molecules    understand    xbp    declines    onset    aggregates    avenues    transgenic    reporter    assays    techniques    proteome    functional    strains    age    what    fewer    animals    specialized    host    transcription    mechanism    therapeutic    transmembrane    editing    biogenesis    organelles    protect    itself    unfolded    biology    er    defines    shutdown    suggesting    ethical    screening    monitoring    create    arisen    elegans    dysfunction    quality    accumulation    weeks    ageing    models    prevent    model    translated    occurs    screen    vertebrate    signalling    microscopy    ire    endoplasmic    crispr    mutagenesis    caenorhabditis    lose    me    genome    biological    disorders    1s    instrumental    function    activation    reticulum    folded    disease    transference    central    proteostasis    properly    alzheimer    monitor    implicated    nematode    folding   

Project "UCUPA" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 212˙933.00

Map

 Project objective

What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorhabditis elegans as a model to understand age-related proteostasis dysfunction. C. elegans offer many advantages over the use of vertebrate models, such as its short lifespan of about two weeks, reduced costs, and fewer ethical issues. We will focus on the UPR pathway, as changes in this pathway have already been implicated in the ageing process itself and in the onset of age-related disorders, such as Alzheimer’s disease. We propose to use CRISPR genome editing to create C. elegans transgenic reporter strains that enable us to track the activity of different UPR signalling molecules using microscopy and molecular biology techniques. We will monitor two central steps of the IRE-1/XBP-1 UPR pathway (1) the activation of the transmembrane sensor protein IRE-1 and (2) the biogenesis of the transcription factor XBP-1s. After age-related changes have been identified, we will use mutagenesis-based screening assays to screen for novel interventions that prevent UPR pathway shutdown. This research will contribute to a better understanding of why ageing occurs, as well as suggesting new therapeutic avenues for age-related disorders. This proposal will also be instrumental for the development and transference of new skills between the host and the applicant that will lead me towards independence.

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The information about "UCUPA" are provided by the European Opendata Portal: CORDIS opendata.

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