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INTEGRATE SIGNED
Personalised Medicine for Intervertebral Disc Regeneration- Integrating Profiling, Predictive Modelling and Gene Activated Biomaterials
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0INTEGRATE project word cloud
Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.
screening
microenvironmental
intervertebral
horizons
ivd
ultimately
trials
global
inflammatory
treat
epidemiological
platform
modulating
invasive
molecules
designed
inflammation
minimally
direct
patient
endogenous
lower
biomaterial
personalised
envisions
treatment
suppression
scientific
vitro
therapies
gene
glucose
matrix
sustained
small
socioeconomic
therapeutic
levels
profiling
therapy
modulate
degenerated
tailoring
opening
disc
environment
transformative
pain
individual
rate
efficacy
clinical
suit
oxygen
proteins
cell
cytokine
advantages
biomaterials
individuals
functionalised
outcomes
fits
silico
strategies
regeneration
combined
offers
size
regulate
synthesis
pursued
acidity
microenvironment
back
possibility
microenvironments
patients
whereby
activated
underway
altered
predict
knowing
Project "INTEGRATE" data sheet
The following table provides information about the project.
| Coordinator |
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 1˙999˙543 € |
| EC max contribution | 1˙999˙543 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-09-01 to 2025-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN | IE (DUBLIN) | coordinator | 1˙754˙543.00 |
| 2 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN | IE (DUBLIN) | participant | 245˙000.00 |
Map
Project objective
Lower back pain is a global epidemiological and socioeconomic problem. Biomaterial and cell-based therapies have been pursued for the treatment of degenerated intervertebral disc (IVD), with a number of clinical trials underway. However, the degenerated intervertebral disc has a distinct environment (e.g. altered oxygen, glucose, acidity, inflammatory cytokine levels) that is unique to an individual (i.e. patient-specific) and will ultimately determine the likelihood and rate at which regeneration can occur. A “one size fits all” approach will lead to the failure to demonstrate efficacy of advanced therapies, as they are not being designed or personalised for individual patients. This proposal envisions a future whereby advanced gene activated cell therapies are personalised (targeting regeneration or modulating inflammation) to treat back pain based on knowing the individuals unique disc microenvironment. This will be achieved through profiling of individual patient disc microenvironmental factors, with in vitro screening and in silico modelling to design cell therapies and predict regeneration outcomes (Aim 1) combined with the development of tailored functionalised gene activated biomaterials (Aim 2), to enhance matrix formation and modulate the inflammatory processes (Aim 3). Gene-based therapy offers several advantages over direct delivery of proteins or small molecules, among them the possibility of sustained efficacy and endogenous synthesis of growth factors or suppression of inflammatory factors and pathways. The platform technology (personalised gene activated biomaterials to regulate regeneration and inflammation) and knowledge (tailoring cell therapies to suit patient-specific microenvironments) generated through this research are beyond the current state-of-the-art and will provide a significant transformative scientific and clinical step change opening new horizons in minimally-invasive therapeutic strategies.
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