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OPERAM SIGNED

OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly

Total Cost €

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EC-Contrib. €

0

Partnership

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 OPERAM project word cloud

Explore the words cloud of the OPERAM project. It provides you a very rough idea of what is the project "OPERAM" about.

trial    population    admissions    pharmacotherapy    effectiveness    multiple    therapy    customised    safety    primary    personalised    multimorbid    excluded    structured    software    elderly    most    75    healthcare    older    utilisation    diseases    userfriendly    nmas    unnecessary    nma    reducing    perform    inappropriate    solutions    compliance    preventable    criteria    chronic    practical    safest    indicated    preferences    isolation    multicentre    health    systematic    trials    aged    stopp    optimal    outcomes    medications    adults    network    multimorbidity    centred    intervention    safe    polypharmacy    underuse    1900    detect    optimisation    start    30    reduce    falls    ultimately    causes    quality    fractures    life    hospital    optimise    randomised    uncertain    drug    poor    investigators    ge    bleeding    limits    clinical    operam    assisted    prescribing    patients    guidelines    reduces    enhanced    patient    discontinuation    meta    interventions    prescription    care    pharmacological   

Project "OPERAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.operam-2020.eu
 Total cost 3˙930˙277 €
 EC max contribution 3˙735˙608 € (95%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 71˙245.00
2    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 1˙084˙375.00
3    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 950˙398.00
4    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) participant 878˙006.00
5    TP21 GMBH DE (BERLIN) participant 269˙000.00
6    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 247˙460.00
7    PANEPISTIMIO IOANNINON EL (IOANNINA) participant 185˙857.00
8    UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA IT (CHIETI) participant 49˙265.00
9    UNIVERSITAT BASEL CH (BASEL) participant 0.00

Map

 Project objective

Most older adults have multiple chronic diseases (multimorbidity) and multiple medications (polypharmacy). However, multimorbid patients are often excluded from clinical trials and most guidelines address diseases in isolation. Inappropriate drug prescription and poor drug compliance are common and contribute to up to 30% of hospital admissions. OPERAM investigators developed STOPP/START criteria to detect inappropriate drug use, both over- and underuse. Applying these criteria limits unnecessary polypharmacy and reduces underuse of indicated medications, but it remains uncertain whether systematic pharmacotherapy optimisation can improve clinical outcomes and reduce costs.We propose a multicentre randomised controlled trial to assess the impact of a userfriendly software-assisted intervention to optimise pharmacotherapy and to enhance compliance in 1900 multimorbid patients aged ≥75 years. Outcomes will include drug-related hospital admissions, health care utilisation, quality of life, patient preferences and cost-effectiveness. We will also perform several network meta-analyses (NMA) to provide new comparative evidence on the most effective and safest pharmacological and non-pharmacological interventions to reduce common causes of preventable hospital admissions (e.g. falls, fractures, bleeding). Therapy optimisation in the multimorbid elderly, enhanced compliance and discontinuation of less effective interventions have the potential to improve clinical, quality of life and safety outcomes, while reducing costs. We will provide a structured method with practical software solutions for optimal prescribing and new comparative evidence from NMAs for addressing multimorbidity and polypharmacy by means of customised, patient-centred guidelines. OPERAM ultimately aims at better healthcare delivery in primary and hospital care, based on effective, safe, personalised and cost-effective interventions that can be applied to the rapidly growing older population in Europe.

 Publications

year authors and title journal last update
List of publications.
2019 Zhengru Shen, Hugo van Krimpen, Marco Spruit
A Lightweight API-Based Approach for Building Flexible Clinical NLP Systems
published pages: 1-11, ISSN: 2040-2295, DOI: 10.1155/2019/3435609
Journal of Healthcare Engineering 2019 2020-04-22
2019 Luise Adam, Elisavet Moutzouri, Christine Baumgartner, Axel Lennart Loewe, Martin Feller, Khadija M’Rabet-Bensalah, Nathalie Schwab, Stefanie Hossmann, Claudio Schneider, Sabrina Jegerlehner, Carmen Floriani, Andreas Limacher, Katharina Tabea Jungo, Corlina Johanna Alida Huibers, Sven Streit, Matthias Schwenkglenks, Marco Spruit, Anette Van Dorland, Jacques Donzé, Patricia M Kearney, Peter Jün
Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial
published pages: , ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-026769
BMJ Open 9:e026769 2020-04-22
2017 Maria Petropoulou, Dimitris Mavridis
A comparison of 20 heterogeneity variance estimators in statistical synthesis of results from studies: a simulation study
published pages: 4266-4280, ISSN: 0277-6715, DOI: 10.1002/sim.7431
Statistics in Medicine 36/27 2020-04-22
2018 Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis O’Mahony, Nicolas Rodondi, Anne Spinewine
International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1007-9
BMC Medicine 16/1 2020-04-22
2017 Chaimani, Anna; Caldwell, Deborah M; Li, Tianjing; Higgins, Julian Pt; Salanti, Georgia
Additional considerations are required when preparing a protocol for a systematic review with multiple interventions.
published pages: 65-74, ISSN: 0895-4356, DOI: 10.7892/boris.94317
Journal of clinical epidemiology 83 2020-04-22
2018 O Riordan, David; Aubert, Carole Elodie; Walsh, Kieran A; Van Dorland, Anette; Rodondi, Nicolas; Du Puy, Robert S; Poortvliet, Rosalinde K E; Gussekloo, Jacobijn; Sinnott, Carol; Byrne, Stephen; Galvin, Rose; Jukema, J Wouter; Mooijaart, Simon P; Baumgartner, Christine; McCarthy, Vera; Walsh, Elaine K; Collet, Tinh-Hai; Dekkers, Olaf M; Blum, Manuel R; Kearney, Patricia M
Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study
published pages: 1-10, ISSN: 2044-6055, DOI: 10.17863/CAM.24741
BMJ open 8 2020-04-22
2017 Beuscart, Jean Baptiste; Dalleur, Olivia; Boland, Benoit; Thevelin, Stefanie; Knol, Wilma; Cullinan, Shane; Schneider, Claudio; O\'Mahony, Denis; Rodondi, Nicolas; Spinewine, Anne
Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol
published pages: 1379-1389, ISSN: 1178-1998, DOI: 10.7892/boris.106338
Clinical Interventions in Aging Vo. 12 2020-04-22
2016 Zhengru Shen, Michiel Meulendijk, Marco Spruit
A federated information architecture for multinational clinical trials: STRIPA revisited
published pages: , ISSN: , DOI:
24th European Conference on Information Systems 2020-04-22
2019 Zhengru Shen, Marco Spruit
A Systematic Review of Open Source Clinical Software on GitHub for Improving Software Reuse in Smart Healthcare
published pages: 150, ISSN: 2076-3417, DOI: 10.3390/app9010150
Applied Sciences 9/1 2020-04-22
2018 Stefanie Thevelin, Anne Spinewine, Jean-Baptiste Beuscart, Benoit Boland, Sophie Marien, Fanny Vaillant, Ingeborg Wilting, Ariel Vondeling, Carmen Floriani, Claudio Schneider, Jacques Donzé, Nicolas Rodondi, Shane Cullinan, Denis O\'Mahony, Olivia Dalleur
Development of a standardized chart review method to identify drug-related hospital admissions in older people
published pages: 2600-2614, ISSN: 0306-5251, DOI: 10.1111/bcp.13716
British Journal of Clinical Pharmacology 84/11 2020-04-22
2017 Jean-Baptiste Beuscart, Lisa G. Pont, Stefanie Thevelin, Benoit Boland, Olivia Dalleur, Anne W. S. Rutjes, Johanna I. Westbrook, Anne Spinewine
A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set
published pages: 942-952, ISSN: 0306-5251, DOI: 10.1111/bcp.13197
British Journal of Clinical Pharmacology 83/5 2020-04-22

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