Explore the words cloud of the RevMito project. It provides you a very rough idea of what is the project "RevMito" about.
The following table provides information about the project.
|Coordinator Country||Finland [FI]|
|Total cost||1˙497˙160 €|
|EC max contribution||1˙497˙160 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-04-01 to 2020-03-31|
Take a look of project's partnership.
|1||HELSINGIN YLIOPISTO||FI (HELSINGIN YLIOPISTO)||coordinator||1˙033˙640.00|
|2||KOC UNIVERSITY||TR (ISTANBUL)||participant||463˙519.00|
Mitochondrial DNA (mtDNA) encodes several proteins playing key roles in bioenergetics. Pathological mutations of mtDNA can be inherited or may accumulate following treatment for viral infections or cancer. Furthermore, many organisms, including humans, accumulate significant mtDNA damage during their lifespan, and it is therefore possible that mtDNA mutations can promote the aging process.
There are no effective treatments for most diseases caused by mtDNA mutation. An understanding of the cellular consequences of mtDNA damage is clearly imperative. Toward this goal, we use the budding yeast Saccharomyces cerevisiae as a cellular model of mitochondrial dysfunction. Genetic manipulation and biochemical study of this organism is easily achieved, and many proteins and processes important for mitochondrial biogenesis were first uncovered and best characterized using this experimental system. Importantly, current evidence suggests that processes required for survival of cells lacking a mitochondrial genome are widely conserved between yeast and other organisms, making likely the application of our findings to human health.
We will study the repercussions of mtDNA damage by three different strategies. First, we will investigate the link between a conserved, nutrient-sensitive signalling pathway and the outcome of mtDNA loss, since much recent evidence points to modulation of such pathways as a potential approach to increase the fitness of cells with mtDNA damage. Second, we will explore the possibility that defects in cytosolic proteostasis are precipitated by mtDNA mutation. Third, we will apply the knowledge and concepts gained in S. cerevisiae to both candidate-based and unbiased searches for genes that determine the aftermath of severe mtDNA damage in human cells. Beyond the mechanistic knowledge of mitochondrial dysfunction that will emerge from this project, we expect to identify new avenues toward the treatment of mitochondrial disease.
|year||authors and title||journal||last update|
Michal Eisenberg-Bord, Hui S. Tsui, Diana Antunes, LucÃa FernÃ¡ndez-del-RÃo, Michelle C. Bradley, Cory D. Dunn, Theresa P. T. Nguyen, Doron Rapaport, Catherine F. Clarke, Maya Schuldiner
The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis
published pages: 251525641882540, ISSN: 2515-2564, DOI: 10.1177/2515256418825409
Oygul Mirzalieva, Shinhye Jeon, Kevin Damri, Ruth Hartke, Layla Drwesh, Keren Demishtein-Zohary, Abdussalam Azem, Cory D. Dunn, Pablo M. Peixoto
Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01960
|Frontiers in Physiology 9||2020-03-31|
Emel AkdoÄŸan, Mehmet Tardu, GÃ¶rkem Garipler, GÃ¼lkÄ±z Baytek, Ä°. Halil Kavakli, Cory D. Dunn
Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA
published pages: e0146511, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0146511
|PLOS ONE 11/1||2019-05-29|
Cory D. Dunn
Some Liked It Hot: A Hypothesis Regarding Establishment of the Proto-Mitochondrial Endosymbiont During Eukaryogenesis
published pages: 99-106, ISSN: 0022-2844, DOI: 10.1007/s00239-017-9809-5
|Journal of Molecular Evolution 85/3-4||2019-05-29|
Abdurrahman Keskin, Emel AkdoÄŸan, Cory D. Dunn
Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane
published pages: 691-705, ISSN: 0016-6731, DOI: 10.1534/genetics.116.196428
GÃ¼leycan LutfullahoÄŸlu-Bal, Abdurrahman Keskin, AyÅŸe Bengisu SeferoÄŸlu, Cory D. Dunn
Bacterial tail anchors can target to the mitochondrial outer membrane
published pages: , ISSN: 1745-6150, DOI: 10.1186/s13062-017-0187-0
|Biology Direct 12/1||2019-05-29|
GÃ¼leycan LutfullahoÄŸlu-Bal, AyÅŸe Bengisu SeferoÄŸlu, Abdurrahman Keskin, Emel AkdoÄŸan, Cory D. Dunn
A bacteria-derived tail anchor localizes to peroxisomes in yeast and mammalian cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34646-7
|Scientific Reports 8/1||2019-05-22|
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