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SYBORG SIGNED

combining SYnthetic Biology and chemistry to create novel CO2-fixing enzymes, ORGanelles and ORGanisms

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SYBORG" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mpi-marburg.mpg.de/erb
 Total cost 1˙746˙038 €
 EC max contribution 1˙746˙038 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙746˙038.00

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 Project objective

'Carbon dioxide (CO2) is a potent greenhouse gas whose presence in the atmosphere is a critical factor for global warming. At the same time atmospheric CO2 is a cheap and readily available carbon source that can in principle be used for the synthesis of biomass/biofuels and value-added products. However, as synthetic chemistry lacks suitable catalysts to functionalize the CO2-molecule, there is an increasing need to exploit the CO2-fixing mechanisms offered by Nature for applications at the interface of chemistry and biology. This proposal is centered on reductive carboxylation, a completely novel principle of enzymatic CO2-fixation that we discovered only recently and that is one of the most efficient CO2-fixation reactions described in biology so far. First, we will focus on understanding the novel principle of reductive carboxylation, by studying its catalysis at molecular scale and single step resolution. This will allow us to derive the first detailed catalytic framework for highly efficient CO2-fixation and enable us to engineer novel carboxylation reactions and products. Second, we will establish a new in vitro platform for the assembly and optimization of artificial ('synthetic') CO2-fixation pathways that are based on reductive carboxylation and that have been calculated to be kinetically and bioenergetically favored compared with naturally existing CO2-fixation pathways. This platform closes a long-standing gap between the theory and practice of synthetic pathway design, and will be used to develop the first functional in vitro module for CO2-fixation, a 'synthetic organelle'. Finally, we will realize synthetic CO2-fixation in selected biological model systems. To that end, we will implement the optimized in vitro pathways in isolated chloroplasts, as well as alpha-proteobacterial hosts to create novel CO2-fixing organelles and organisms, breaking new grounds in understanding and engineering biological systems for efficient CO2-fixation.'

 Publications

year authors and title journal last update
List of publications.
2019 Iria Bernhardsgrütter, Kristina Schell, Dominik M. Peter, Farshad Borjian, David Adrian Saez, Esteban Vöhringer-Martinez, Tobias J. Erb
Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO 2 -Binding Potential of Reductases
published pages: 9778-9782, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03431
Journal of the American Chemical Society 141/25 2020-04-14
2019 Gabriele M. M. Stoffel, David Adrian Saez, Hasan DeMirci, Bastian Vögeli, Yashas Rao, Jan Zarzycki, Yasuo Yoshikuni, Soichi Wakatsuki, Esteban Vöhringer-Martinez, Tobias J. Erb
Four amino acids define the CO 2 binding pocket of enoyl-CoA carboxylases/reductases
published pages: 13964-13969, ISSN: 0027-8424, DOI: 10.1073/pnas.1901471116
Proceedings of the National Academy of Sciences 116/28 2020-04-14
2018 Simon Burgener, Thomas Schwander, Elvira Romero, Marco Fraaije, Tobias Erb
Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase
published pages: 68, ISSN: 1420-3049, DOI: 10.3390/molecules23010068
Molecules 23/1 2020-04-14
2015 Dominik M. Peter, Lennart Schada von Borzyskowski, Patrick Kiefer, Philipp Christen, Julia A. Vorholt, Tobias J. Erb
Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis
published pages: 13457-13461, ISSN: 1433-7851, DOI: 10.1002/anie.201505282
Angewandte Chemie International Edition 54/45 2020-04-14
2018 Tobias J Erb, Jan Zarzycki
A short history of RubisCO: the rise and fall (?) of Nature\'s predominant CO 2 fixing enzyme
published pages: 100-107, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.07.017
Current Opinion in Biotechnology 49 2020-04-14
2018 Thomas Schwander, Richard McLean, Jan Zarzycki, Tobias J. Erb
Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family
published pages: 1702-1712, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.000764
Journal of Biological Chemistry 293/5 2020-04-14
2016 Thomas Schwander, Lennart Schada von Borzyskowski, Simon Burgener, Niña Socorro Cortina, Tobias J. Erb
A synthetic pathway for the fixation of carbon dioxide in vitro
published pages: 900-904, ISSN: 0036-8075, DOI: 10.1126/science.aah5237
Science 354/6314 2020-04-14
2016 Dominik Peter, Bastian Vögeli, Niña Cortina, Tobias Erb
A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters
published pages: 517, ISSN: 1420-3049, DOI: 10.3390/molecules21040517
Molecules 21/4 2020-04-14
2017 Johannes Döhlemann, Marcel Wagner, Carina Happel, Martina Carrillo, Patrick Sobetzko, Tobias J. Erb, Martin Thanbichler, Anke Becker
A Family of Single Copy repABC -Type Shuttle Vectors Stably Maintained in the Alpha-Proteobacterium Sinorhizobium meliloti
published pages: 968-984, ISSN: 2161-5063, DOI: 10.1021/acssynbio.6b00320
ACS Synthetic Biology 6/6 2020-04-14
2017 Raoul G Rosenthal, Bastian Vögeli, Tristan Wagner, Seigo Shima, Tobias J Erb
A conserved threonine prevents self-intoxication of enoyl-thioester reductases
published pages: 745-749, ISSN: 1552-4450, DOI: 10.1038/nchembio.2375
Nature Chemical Biology 13/7 2020-04-14
2016 Tobias J Erb, Jan Zarzycki
Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation
published pages: 72-79, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.06.026
Current Opinion in Chemical Biology 34 2020-04-14
2017 Tobias J Erb, Patrik R Jones, Arren Bar-Even
Synthetic metabolism: metabolic engineering meets enzyme design
published pages: 56-62, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.12.023
Current Opinion in Chemical Biology 37 2020-04-14

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