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AArteMIS SIGNED

Aneurysmal Arterial Mechanics: Into the Structure

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AArteMIS" data sheet

The following table provides information about the project.

Coordinator
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS 

Organization address
address: BOULEVARD SAINT MICHEL 60
city: PARIS
postcode: 75272
website: www.armines.net

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.emse.fr/
 Total cost 1˙499˙783 €
 EC max contribution 1˙499˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS FR (PARIS) coordinator 1˙377˙033.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 86˙556.00
3    CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU FR (SAINT ETIENNE) participant 36˙192.00

Map

 Project objective

The rupture of an Aortic Aneurysm (AA), which is often lethal, is a mechanical phenomenon that occurs when the wall stress state exceeds the local strength of the tissue. Our current understanding of arterial rupture mechanisms is poor, and the physics taking place at the microscopic scale in these collagenous structures remains an open area of research. Understanding, modelling, and quantifying the micro-mechanisms which drive the mechanical response of such tissue and locally trigger rupture represents the most challenging and promising pathway towards predictive diagnosis and personalized care of AA. The PI's group was recently able to detect, in advance, at the macro-scale, rupture-prone areas in bulging arterial tissues. The next step is to get into the details of the arterial microstructure to elucidate the underlying mechanisms. Through the achievements of AArteMIS, the local mechanical state of the fibrous microstructure of the tissue, especially close to its rupture state, will be quantitatively analyzed from multi-photon confocal microscopy and numerically reconstructed to establish quantitative micro-scale rupture criteria. AArteMIS will also address developing micro-macro models which are based on the collected quantitative data. The entire project will be completed through collaboration with medical doctors and engineers, experts in all required fields for the success of AArteMIS. AArteMIS is expected to open longed-for pathways for research in soft tissue mechanobiology which focuses on cell environment and to enable essential clinical applications for the quantitative assessment of AA rupture risk. It will significantly contribute to understanding fatal vascular events and improving cardiovascular treatments. It will provide a tremendous source of data and inspiration for subsequent applications and research by answering the most fundamental questions on AA rupture behaviour enabling ground-breaking clinical changes to take place.

 Publications

year authors and title journal last update
List of publications.
2019 Cristina Cavinato, Jerome Molimard, Nicolas Curt, Salvatore Campisi, Laurent Orgéas, Pierre Badel
Does the Knowledge of the Local Thickness of Human Ascending Thoracic Aneurysm Walls Improve Their Mechanical Analysis?
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00169
Frontiers in Bioengineering and Biotechnology 7 2020-02-26
2019 Joseph Brunet, Baptiste Pierrat, Pierre Badel
Review of current advances in the mechanical description and quantification of aortic dissection mechanisms
published pages: 1-1, ISSN: 1937-3333, DOI: 10.1109/rbme.2019.2950140
IEEE Reviews in Biomedical Engineering 2020-02-26
2019 Venkat Ayyalasomayajula, Baptiste Pierrat, Pierre Badel
A computational model for understanding the micro-mechanics of collagen fiber network in the tunica adventitia
published pages: , ISSN: 1617-7959, DOI: 10.1007/s10237-019-01161-1
Biomechanics and Modeling in Mechanobiology 2020-02-26
2017 F. Condemi, S. Campisi, M. Viallon, T. Troalen, G. Xuexin, A. J. Barker, M. Markl, P. Croisille, O. Trabelsi, C. Cavinato, A. Duprey, S. Avril
Fluid- and Biomechanical Analysis of Ascending Thoracic Aorta Aneurysm with Concomitant Aortic Insufficiency
published pages: 2921-2932, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1913-6
Annals of Biomedical Engineering 45/12 2020-02-26
2019 J. Brunet, B. Pierrat, E. Maire, J. Adrien, P. Badel
A combined experimental-numerical lamellar-scale approach of tensile rupture in arterial medial tissue using X-ray tomography
published pages: 116-123, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2019.03.028
Journal of the Mechanical Behavior of Biomedical Materials 95 2020-02-26
2016 Cavinato C, Helfenstein-Didier C, Olivier T, Badel P
A new experimental approach to characterize arterial deformation micro-mechanisms
published pages: , ISSN: , DOI:
2020-02-26
2017 Cavinato C, Helfenstein-Didier C, Olivier T, Badel P
In situ microscopic investigation of arterial tissue during a bulge inflation test
published pages: , ISSN: , DOI:
2020-02-26
2017 Cavinato C, Helfenstein-Didier C, Olivier T, Badel P
A new experimental approach to characterize arterial deformation micro-mechanisms
published pages: , ISSN: , DOI:
2020-02-26
2017 Cristina Cavinato, Clementine Helfenstein-Didier, Thomas Olivier, Sabine Rolland du Roscoat, Norbert Laroche, Pierre Badel
Biaxial loading of arterial tissues with 3D in situ observations of adventitia fibrous microstructure: A method coupling multi-photon confocal microscopy and bulge inflation test
published pages: 488-498, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.07.022
Journal of the Mechanical Behavior of Biomedical Materials 74 2020-02-26
2018 Clémentine Helfenstein-Didier, Damien Taïnoff, Julien Viville, Jérôme Adrien, Éric Maire, Pierre Badel
Tensile rupture of medial arterial tissue studied by X-ray micro-tomography on stained samples
published pages: 362-368, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.11.032
Journal of the Mechanical Behavior of Biomedical Materials 78 2020-02-26
2016 Helfenstein-Didier Clémentine, Taïnoff Damien, Viville Julien, Adrien Jérôme, Maire Eric, Badel Pierre
In situ tensile testing of medial arterial tissue in X-ray microtomography
published pages: , ISSN: , DOI:
22nd Congress of the European Society of Biomechanics 2020-02-26

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