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PhilPharm SIGNED

Philosophy of Pharmacology: Safety, Statistical standards and Evidence Amalgamation

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "PhilPharm" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA POLITECNICA DELLE MARCHE 

Organization address
address: PIAZZA ROMA 22
city: ANCONA
postcode: 60121
website: www.univpm.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://philpharmblog.wordpress.com/
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA POLITECNICA DELLE MARCHE IT (ANCONA) coordinator 643˙084.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 856˙915.00
3    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 0.00

Map

 Project objective

'The project intends addresses safety assessment in pharmacology with a view on philosophical work on causality and causal inference from statistical data ((Pearl 2000; Spirtes, Glymour, Scheines 2000, Woodward 2003, Cartwright, 2007b). This interest is motivated by the fact that current evidence standards emphasize internal validity of studies and hence randomization, disregarding alternative routes to causal assessment, such as the joint support of different sorts of evidence to a given hypothesis. This may be particularly detrimental in that, much of the evidence for harms comes from anecdotal reports, case series, or survey data, which standard guidelines of evidence evaluation regard as being of poorer quality with respect to controlled (randomized) experiments. Although the role of this 'lower level' evidence is increasingly acknowledged to be a valid source of information for the risk profile of medications (Howick et al. 2009, Hauben and Aronson, 2007), current practices have difficulty in assigning it a precise epistemic status and integrating it with more standard methods of hypothesis testing. The philosophical debate has already addressed similar questions in relation to the assessment of treatment efficacy (Worral 2010, Papineau, 1993; Cartwright, 2007). However, none of these contributions expressly addresses the specific issues arising in causal assessment for harms. The project intends to change the evidence standards for safety assessment by providing a unified framework for the amalgamation of diverse evidence in safety assessment. In particular, the project intends to: 1) present a foundational analysis on statistical/causal inference with a focus on safety assessment; 2) Build a unified epistemic framework within which different kinds of evidence can be combined and used for decision; 3) Provide the theoretical framework for the development of new standards of drug evaluation. '

 Publications

year authors and title journal last update
List of publications.
2015 Howick J., Graham KA, Mebius A. (2015)
Philosophy of Evidence Based Medicine
published pages: , ISSN: , DOI:
Oxford Bibliographies 2019-09-02
2016 Jürgen Landes, George Masterton
Invariant Equivocation
published pages: , ISSN: 0165-0106, DOI: 10.1007/s10670-016-9810-1
Erkenntnis 2019-09-02
2016 Alexander Mebius
Assigning Functions to Medical Technologies
published pages: , ISSN: 2210-5433, DOI: 10.1007/s13347-016-0241-3
Philosophy & Technology 2019-09-02
2018 Barbara Osimani, Marta Bertolaso, Emanuele Frontoni, Roland Poellinger
Real and Virtual Clinical Trials: A Formal Analysis
published pages: , ISSN: 0167-7411, DOI:
TOPOI 2019-09-02
2017 Ãœrgen Landes, Barbara Osimani, Roland Poellinger
Epistemology of Causal Inference in Pharmacology. Towards a Framework for the Assessment of Harms
published pages: , ISSN: 1879-4912, DOI:
European Journal for Philosophy of Science 2019-09-02
2016 Alexander Mebius, Ashley Graham Kennedy, Jeremy Howick
Research gaps in the philosophy of evidence-based medicine
published pages: 757-771, ISSN: 1747-9991, DOI: 10.1111/phc3.12352
Philosophy Compass 11/11 2019-09-02
2016 Jürgen Landes, Jon Williamson
Objective Bayesian nets from consistent datasets
published pages: 20007, ISSN: , DOI: 10.1063/1.4959048
AIP Conference Proceedings volume 1758 2019-09-02
2017 Samuel C. Fletcher, Jürgen Landes, Roland Poellinger (eds.)
Special issue: Evidence Amalgamation in the Sciences
published pages: , ISSN: , DOI:
2019-09-02
2017 Roland Poellinger
Analogy-Based Inference Patterns in Pharmacological Research
published pages: , ISSN: , DOI:
Osimani, Barbara and Adam La Caze (eds.): Uncertainty in Pharmacology: Epistemology, Methods, and Decisions. 2019-09-02
2018 Barbara Osimani
What\'s Hot in Mathematical Philosophy? Formal Epistemology of Medicine
published pages: , ISSN: 1757-0522, DOI:
The Reasoner Volume 12, Number 2 – Februar 2019-09-02
2016 Jürgen Landes, Jon Williamson
Special issue: Combining probability and logic
published pages: 1-2, ISSN: 1570-8683, DOI: 10.1016/j.jal.2015.09.009
Journal of Applied Logic 14 2019-09-02
2019 Barbara Osimani, Roland Poellinger
Causal Inference through Computational Modelling: A Protocol for Model Validation
published pages: , ISSN: , DOI:
Will Science Remain Human? 2019 2019-09-02
2019 Jürgen Landes
An Evidence-Hierarchical Decision Aid for Ranking in Evidence-Based Medicine. In Barbara Osimani and Adam La Caze, editors,
published pages: , ISSN: , DOI:
Uncertainty in Pharmacology: Epistemology, Methods and Decisions, Boston Studies for the Philosophy and History of Science. Springer. 2019-09-02
2018 Jürgen Landes
L&P-updating - All Bets Are Off. The Reasoner, 12 (2): page 10, 2018.
published pages: , ISSN: 1757-0522, DOI:
The Reasoner 2019-09-02

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