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VASCFLAP

A new reconstructing technique using tissue engineering methods to create an engineered autologous vascularized tissue flap

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VASCFLAP project word cloud

Explore the words cloud of the VASCFLAP project. It provides you a very rough idea of what is the project "VASCFLAP" about.

treatment    abdominal    human    possibility    reconstruction    free    harvesting    disadvantages    transfer    reconstructive    portfolio    injured    blood    niche    alternative    complicated    severe    donor    contain    full    skinsubcutisfasciamuscle    isolated    wall    cancer    repair    minimal    defects    name    supply    lifted    vitro    thickness    vessels    overcome    network    animal    alone    breast    scarification    construct    muscle    improves    burns    tissue    risks    implanted    intellectual    surgical    morbidity    technique    scant    consequence    skin    polymeric    involve    cells    idea    flap    quality    property    patients    vascularized    market    defect    seeded    plan    once    postoperative    cultured    scaffold    complete    life    feasibility    engineered    autologous    uses    model    adjacent    axial    establishing    thousands    biomaterial    moved    reduces    implantation    performed    patient    intact    trauma    describe    surgery    later    transplant    site   

Project "VASCFLAP" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 147˙500 €
 EC max contribution 147˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 147˙500.00

Map

 Project objective

'Abdominal wall defects are often the consequence of severe trauma, cancer treatment and burns. These defects involve a significant loss of tissue, and often require surgical reconstruction where tissue is lifted from the patient's donor site and moved to his injured site with an intact blood supply (autologous muscle free flap). The current transfer surgery is complicated and involved with donor-site morbidity after tissue harvesting, and scant availability. We propose a robust engineered transplant performed by a novel reconstruction technique to overcome these disadvantages. The proposed transplant uses an alternative biomaterial implantation, offering the possibility to repair a full-thickness defect of the abdominal wall without the need to transfer tissue (skinsubcutisfasciamuscle) from another site and minimal postoperative scarification (skin only). We name this technique 'an Engineered Autologous Vascularized Axial Flap'. The key idea of this approach is the use of a polymeric scaffold upon which human cells will be seeded. The engineered tissue cultured in vitro will contain also a network of blood vessels. Then, this engineered construct will be implanted around large blood vessels adjacent to the injured site. Once highly vascularized, it will be possible to transfer the implanted engineered vascularized construct as a flap for covering the defects. Once developed, this autologous cost-effective engineered tissue product may be used in reconstructive surgery of the abdominal wall and breast (thousands of cases in the EU alone) which improves the patients’ quality of life and reduces surgical costs and risks. Here we describe a plan to develop this product by identifying the most cost-effective niche where we can go to market in. We plan to complete a set of feasibility studies in large animal model using human cells (which could later be isolated from the patient = autologous cells) and proceed establishing our portfolio of intellectual property.'

 Publications

year authors and title journal last update
List of publications.
2016 Alina Freiman, Yulia Shandalov, Dekel Rozenfeld, Erez Shor, Sofia Segal, Dror Ben-David, Shai Meretzki, Dana Egozi, Shulamit Levenberg
Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro
published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-015-0251-6
Stem Cell Research & Therapy 7/1 2019-07-22

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The information about "VASCFLAP" are provided by the European Opendata Portal: CORDIS opendata.

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