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A new reconstructing technique using tissue engineering methods to create an engineered autologous vascularized tissue flap

Total Cost €


EC-Contrib. €






 VASCFLAP project word cloud

Explore the words cloud of the VASCFLAP project. It provides you a very rough idea of what is the project "VASCFLAP" about.

trauma    blood    name    thickness    describe    contain    moved    network    polymeric    tissue    human    breast    cells    biomaterial    defect    animal    wall    quality    abdominal    patient    transfer    reconstructive    scarification    later    improves    consequence    seeded    surgery    model    reconstruction    once    muscle    site    niche    postoperative    free    injured    flap    property    treatment    donor    establishing    vascularized    plan    technique    portfolio    intact    complete    idea    cultured    complicated    autologous    feasibility    reduces    adjacent    performed    morbidity    disadvantages    minimal    skin    market    possibility    life    patients    intellectual    overcome    repair    full    alternative    uses    harvesting    thousands    involve    alone    severe    skinsubcutisfasciamuscle    scaffold    axial    vessels    transplant    construct    burns    isolated    implantation    risks    engineered    lifted    supply    surgical    scant    defects    cancer    implanted    vitro   

Project "VASCFLAP" data sheet

The following table provides information about the project.


Organization address
city: HAIFA
postcode: 32000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 147˙500 €
 EC max contribution 147˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

'Abdominal wall defects are often the consequence of severe trauma, cancer treatment and burns. These defects involve a significant loss of tissue, and often require surgical reconstruction where tissue is lifted from the patient's donor site and moved to his injured site with an intact blood supply (autologous muscle free flap). The current transfer surgery is complicated and involved with donor-site morbidity after tissue harvesting, and scant availability. We propose a robust engineered transplant performed by a novel reconstruction technique to overcome these disadvantages. The proposed transplant uses an alternative biomaterial implantation, offering the possibility to repair a full-thickness defect of the abdominal wall without the need to transfer tissue (skinsubcutisfasciamuscle) from another site and minimal postoperative scarification (skin only). We name this technique 'an Engineered Autologous Vascularized Axial Flap'. The key idea of this approach is the use of a polymeric scaffold upon which human cells will be seeded. The engineered tissue cultured in vitro will contain also a network of blood vessels. Then, this engineered construct will be implanted around large blood vessels adjacent to the injured site. Once highly vascularized, it will be possible to transfer the implanted engineered vascularized construct as a flap for covering the defects. Once developed, this autologous cost-effective engineered tissue product may be used in reconstructive surgery of the abdominal wall and breast (thousands of cases in the EU alone) which improves the patients’ quality of life and reduces surgical costs and risks. Here we describe a plan to develop this product by identifying the most cost-effective niche where we can go to market in. We plan to complete a set of feasibility studies in large animal model using human cells (which could later be isolated from the patient = autologous cells) and proceed establishing our portfolio of intellectual property.'


year authors and title journal last update
List of publications.
2016 Alina Freiman, Yulia Shandalov, Dekel Rozenfeld, Erez Shor, Sofia Segal, Dror Ben-David, Shai Meretzki, Dana Egozi, Shulamit Levenberg
Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro
published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-015-0251-6
Stem Cell Research & Therapy 7/1 2019-07-22

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The information about "VASCFLAP" are provided by the European Opendata Portal: CORDIS opendata.

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