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VASCFLAP

A new reconstructing technique using tissue engineering methods to create an engineered autologous vascularized tissue flap

Total Cost €

EC-Contrib. €

Partnership

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VASCFLAP project word cloud

Explore the words cloud of the VASCFLAP project. It provides you a very rough idea of what is the project "VASCFLAP" about.

scant disadvantages feasibility construct axial patients model property flap life supply thickness adjacent wall biomaterial autologous cells market postoperative describe minimal vitro blood skinsubcutisfasciamuscle morbidity burns later quality free technique once treatment reconstructive patient vessels repair complicated intact scarification tissue reduces possibility defect animal risks alternative donor surgical lifted isolated polymeric abdominal human involve alone name trauma seeded improves implantation full portfolio transplant cancer harvesting thousands skin surgery engineered site injured establishing contain niche scaffold consequence performed implanted defects reconstruction overcome transfer intellectual breast severe network uses complete vascularized moved cultured muscle idea plan

Project "VASCFLAP" data sheet

The following table provides information about the project.

Coordinator	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Organization address address: SENATE BUILDING TECHNION CITY city: HAIFA postcode: 32000 website: www.technion.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	147˙500 €
EC max contribution	147˙500 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-PoC
Funding Scheme	ERC-POC
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2016-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Organization address address: SENATE BUILDING TECHNION CITY city: HAIFA postcode: 32000 website: www.technion.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (HAIFA)	coordinator	147˙500.00

Map

Project objective

'Abdominal wall defects are often the consequence of severe trauma, cancer treatment and burns. These defects involve a significant loss of tissue, and often require surgical reconstruction where tissue is lifted from the patient's donor site and moved to his injured site with an intact blood supply (autologous muscle free flap). The current transfer surgery is complicated and involved with donor-site morbidity after tissue harvesting, and scant availability. We propose a robust engineered transplant performed by a novel reconstruction technique to overcome these disadvantages. The proposed transplant uses an alternative biomaterial implantation, offering the possibility to repair a full-thickness defect of the abdominal wall without the need to transfer tissue (skinsubcutisfasciamuscle) from another site and minimal postoperative scarification (skin only). We name this technique 'an Engineered Autologous Vascularized Axial Flap'. The key idea of this approach is the use of a polymeric scaffold upon which human cells will be seeded. The engineered tissue cultured in vitro will contain also a network of blood vessels. Then, this engineered construct will be implanted around large blood vessels adjacent to the injured site. Once highly vascularized, it will be possible to transfer the implanted engineered vascularized construct as a flap for covering the defects. Once developed, this autologous cost-effective engineered tissue product may be used in reconstructive surgery of the abdominal wall and breast (thousands of cases in the EU alone) which improves the patients’ quality of life and reduces surgical costs and risks. Here we describe a plan to develop this product by identifying the most cost-effective niche where we can go to market in. We plan to complete a set of feasibility studies in large animal model using human cells (which could later be isolated from the patient = autologous cells) and proceed establishing our portfolio of intellectual property.'

Publications

List of publications.
year	authors and title	journal	last update
2016	Alina Freiman, Yulia Shandalov, Dekel Rozenfeld, Erez Shor, Sofia Segal, Dror Ben-David, Shai Meretzki, Dana Egozi, Shulamit Levenberg Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-015-0251-6	Stem Cell Research & Therapy 7/1	2019-07-22

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The information about "VASCFLAP" are provided by the European Opendata Portal: CORDIS opendata.