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SENSEI

Sequence-Enabled Single cEll Identification device

Total Cost €

EC-Contrib. €

Partnership

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SENSEI project word cloud

Explore the words cloud of the SENSEI project. It provides you a very rough idea of what is the project "SENSEI" about.

rna cell single blatantly hallmark description classification medicine biology fashion sequencing 2014 building pathologies tissues profound accurate organisms technique data gene populations consumables pathological hundreds al expression rnas dramatically biological functionally science sequence broad profile unbiased published simultaneously basic sampling characterization diabetes cellular treatment enabled super applicable diagnostics blocks et immediately personalized quantities dynamic jaitin parallel massively coherent commercialize billion organs clinics standard resolution subpopulations limitations evident block profiling cells invention dynamics market reconstruct functions monitor cancer affordable molecular starting benefits impossible industry clinical dollar sensei labs functional identification

Project "SENSEI" data sheet

The following table provides information about the project.

Coordinator	WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-PoC
Funding Scheme	ERC-POC
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2016-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	coordinator	150˙000.00

Map

Project objective

The dynamics of cell populations within tissues and organs is a hallmark of multi-cellular organisms. In many pathological states (e.g. cancer, diabetes etc) the functions and quantities of specific cell populations change. The ability to simultaneously and effectively monitor these functions and changes is essential for the study of these pathologies and the development of diagnostics and treatment. While single cell profiling is a multi billion dollar market, currently, unbiased and comprehensive classification of tissues into well-defined and functionally coherent cell subpopulations is impossible due to limitations in technology. Here we propose commercialize a technology we recently developed and published (Jaitin et al Science 2014) - Sequence-Enabled Single cEll identification (SENSEI) - based on massively parallel sequencing of RNA from single cells. Using broad sampling of single cell functional states from multi-cellular tissues we reconstruct biological functions in a bottom-up fashion, starting from the most basic building block – the cell. The potential benefits of this invention are blatantly evident. Since cells are the basic building blocks of multi cellular organisms accurate and dynamic description of cell states and functions is essential for both basic biological research and personalized medicine clinical applications. Our technique is immediately applicable in molecular biology labs, clinics or industry, requires no specific equipment beyond our developed consumables and can provide data on RNAs from hundreds of single cells at the cost of one standard average gene expression profile. Massively parallel single cell RNA sequencing is therefore emerging as a super high-resolution, robust and affordable approach for unbiased functional characterization of complex tissues and is likely going to dramatically change molecular research and have profound clinical applications.

Publications

List of publications.
year	authors and title	journal	last update
2016	Meital Gury-BenAri, ChristophÂ A. Thaiss, Nicolas Serafini, DeborahÂ R. Winter, Amir Giladi, David Lara-Astiaso, Maayan Levy, TomerÂ Meir Salame, Assaf Weiner, Eyal David, Hagit Shapiro, Mally Dori-Bachash, Meirav Pevsner-Fischer, Erika Lorenzo-Vivas, Hadas Keren-Shaul, Franziska Paul, Alon Harmelin, GÃ©rard Eberl, Shalev Itzkovitz, Amos Tanay, JamesÂ P. DiÂ Santo, Eran Elinav, Ido Amit The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome published pages: 1231-1246.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.07.043	Cell 166/5	2019-07-23
2016	O. Matcovitch-Natan, D. R. Winter, A. Giladi, S. Vargas Aguilar, A. Spinrad, S. Sarrazin, H. Ben-Yehuda, E. David, F. Zelada Gonzalez, P. Perrin, H. Keren-Shaul, M. Gury, D. Lara-Astaiso, C. A. Thaiss, M. Cohen, K. Bahar Halpern, K. Baruch, A. Deczkowska, E. Lorenzo-Vivas, S. Itzkovitz, E. Elinav, M. H. Sieweke, M. Schwartz, I. Amit Microglia development follows a stepwise program to regulate brain homeostasis published pages: aad8670-aad8670, ISSN: 0036-8075, DOI: 10.1126/science.aad8670	Science 353/6301	2019-07-23
2015	Franziska Paul, Yaâ€™ara Arkin, Amir Giladi, DiegoÂ Adhemar Jaitin, Ephraim Kenigsberg, Hadas Keren-Shaul, Deborah Winter, David Lara-Astiaso, Meital Gury, Assaf Weiner, Eyal David, Nadav Cohen, FeliciaÂ KathrineÂ Bratt Lauridsen, Simon Haas, Andreas Schlitzer, Alexander Mildner, Florent Ginhoux, Steffen Jung, Andreas Trumpp, BoÂ Torben Porse, Amos Tanay, Ido Amit Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors published pages: 1663-1677, ISSN: 0092-8674, DOI: 10.1016/j.cell.2015.11.013	Cell 163/7	2019-07-23

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The information about "SENSEI" are provided by the European Opendata Portal: CORDIS opendata.

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