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ANTIVIRALS SIGNED

European Training Network on Antiviral Drug Development

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ANTIVIRALS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.antivirals-etn.eu
 Total cost 3˙837˙214 €
 EC max contribution 3˙837˙214 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 510˙748.00
2    CARDIFF UNIVERSITY UK (CARDIFF) participant 546˙575.00
3    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 525˙751.00
4    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 510˙748.00
5    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 498˙432.00
6    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 402˙055.00
7    VIROVET BE (LEUVEN) participant 250˙560.00
8    AICURIS GMBH & CO. KG DE (WUPPERTAL) participant 249˙216.00
9    UNIVERSITAT WIEN AT (WIEN) participant 244˙061.00
10    COMPLIX LUXEMBOURG SA LU (LUXEMBOURG) participant 99˙063.00
11    ARATANA THERAPEUTICS NV BE (HEVERLEE) participant 0.00
12    COMPLIX NV BE (DIEPENBEEK) participant 0.00
13    Virology Education NL (Utrecht) partner 0.00

Map

 Project objective

Viral infections are a major cause of disease, mortality and economic losses worldwide. Antiviral therapy is an essential instrument to control virus infections. At present, however, licensed antiviral drugs have been developed only against a limited number of viruses (e.g. HIV, HCV, influenza, herpesviruses). There is a clear and unmet need for antiviral drugs to treat infections with other important human pathogens.

Europe needs well-trained experts with multidisciplinary skills to advance the antiviral drug development field. However, few, if any, European universities or research institutes have the ability to deliver an intersectoral training programme that covers the broad spectrum of disciplines important for antiviral drug development.

The ANTIVIRALS partnership has been established to fill this gap. It consists of six outstanding European academic partners and four industrial partners (two large R&D companies, of which one is specialized in antiviral drug discovery and development, and two SMEs), and two partner organisations (incl. one SME specialised in education). All partners are leaders in their field, ensuring state-of-the-art training possibilities, and their skills are highly complementary.

ANTIVIRALS aims to introduce 15 ESRs to state-of-the-art knowledge and technology applied in antiviral drug development through both local and network-wide training activities. Individual research projects, research training workshops and intersectoral secondments will be supplemented with complementary skills courses and dissemination activities to improve career development and perspectives. The industrial partners are actively involved in the entire programme and will organize an industry-oriented conference aimed at further bridging the gap between academia and industry.

Thus, ANTIVIRALS offers talented researchers a multidisciplinary and intersectoral training programme and prepares them for a future leading role in antiviral drug development in Europe.

 Deliverables

List of deliverables.
ESR weblog Websites, patent fillings, videos etc. 2020-02-27 15:43:43
PhD Thesis Titles & Degrees Documents, reports 2020-02-27 15:43:43
International conference Other 2020-02-27 15:43:43
Recruitment Other 2019-10-29 16:55:23
ANTIVIRALS website Websites, patent fillings, videos etc. 2019-10-29 16:55:24

Take a look to the deliverables list in detail:  detailed list of ANTIVIRALS deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 François Ferron, Lorenzo Subissi, Ana Theresa Silveira De Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, Gérard Bricogne, Bruno Canard, Isabelle Imbert
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA
published pages: E162-E171, ISSN: 0027-8424, DOI: 10.1073/pnas.1718806115
Proceedings of the National Academy of Sciences 115/2 2019-11-22
2017 Charlotte E. Melia, Hilde M. van der Schaar, Heyrhyoung Lyoo, Ronald W.A.L. Limpens, Qian Feng, Maryam Wahedi, Gijs J. Overheul, Ronald P. van Rij, Eric J. Snijder, Abraham J. Koster, Montserrat Bárcena, Frank J.M. van Kuppeveld
Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles
published pages: 587-599, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.09.068
Cell Reports 21/3 2019-11-22
2017 Heyrhyoung Lyoo, Cristina M. Dorobantu, Hilde M. van der Schaar, Frank J.M. van Kuppeveld
Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein
published pages: 86-90, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.10.006
Antiviral Research 147 2019-11-22
2017 Jih Ru Hwu, Nitesh K. Gupta, Shwu-Chen Tsay, Wen-Chieh Huang, Irina C. Albulescu, Kristina Kovacikova, Martijn J. van Hemert
Bis(benzofuran–thiazolidinone)s and bis(benzofuran–thiazinanone)s as inhibiting agents for chikungunya virus
published pages: 96-101, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.08.008
Antiviral Research 146 2019-11-22
2016 Rachel Ulferts, S. Matthijn de Boer, Lonneke van der Linden, Lisa Bauer, Hey Rhyoung Lyoo, Maria J. Maté, Julie Lichière, Bruno Canard, Daphne Lelieveld, Wienand Omta, David Egan, Bruno Coutard, Frank J. M. van Kuppeveld
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C
published pages: 2627-2638, ISSN: 0066-4804, DOI: 10.1128/AAC.02182-15
Antimicrobial Agents and Chemotherapy 60/5 2019-11-22
2017 Irina C. Albulescu, Kristina Kovacikova, Ali Tas, Eric J. Snijder, Martijn J. van Hemert
Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles
published pages: 230-236, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.04.016
Antiviral Research 143 2019-11-22
2017 Tassini S, Sun L, Lanko K, Crespan E, Langron E, Falchi F, Kissova M, Armijos-Rivera JI, Delang L, Mirabelli C, Neyts J, Pieroni M, Cavalli A, Costantino G, Maga G, Vergani P, Leyssen P, Radi M
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.
published pages: 1400-1416, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01521
J Med Chem 60(4) 2019-11-22
2017 Lisa Bauer, Heyrhyoung Lyoo, Hilde M van der Schaar, Jeroen RPM Strating, Frank JM van Kuppeveld
Direct-acting antivirals and host-targeting strategies to combat enterovirus infections
published pages: 1-8, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2017.03.009
Current Opinion in Virology 24 2019-11-22
2017 Kristina Lanko, Kristel Eggermont, Abdulsamie Patel, Suzanne Kaptein, Leen Delang, Catherine M. Verfaillie, Johan Neyts
Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals
published pages: 82-86, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.07.010
Antiviral Research 145 2019-11-22
2016 Cristina M. Dorobantu, Lucian Albulescu, Heyrhyoung Lyoo, Mirjam van Kampen, Raffaele De Francesco, Volker Lohmann, Christian Harak, Hilde M. van der Schaar, Jeroen R. P. M. Strating, Alexander E. Gorbalenya, Frank J. M. van Kuppeveld
Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein
published pages: e00068-16, ISSN: 2379-5042, DOI: 10.1128/mSphere.00068-16
mSphere 1/3 2019-11-22
2017 Jeroen RPM Strating, Frank JM van Kuppeveld
Viral rewiring of cellular lipid metabolism to create membranous replication compartments
published pages: 24-33, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2017.02.005
Current Opinion in Cell Biology 47 2019-11-07
2019 Susan Schuster, Gijs J. Overheul, Lisa Bauer, Frank J. M. van Kuppeveld, Ronald P. van Rij
No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50287-w
Scientific Reports 9/1 2019-11-07
2019 Vladimira Horova, Heyrhyoung Lyoo, Bartosz Różycki, Dominika Chalupska, Miroslav Smola, Jana Humpolickova, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld, Evzen Boura, Martin Klima
Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites
published pages: e1007962, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007962
PLOS Pathogens 15/8 2019-10-03
2019 Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Félix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid
published pages: e1007760, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007760
PLOS Pathogens 15/5 2019-10-03
2019 Jim Baggen, Yue Liu, Heyrhyoung Lyoo, Arno L. W. van Vliet, Maryam Wahedi, Jost W. de Bruin, Richard W. Roberts, Pieter Overduin, Adam Meijer, Michael G. Rossmann, Hendrik Jan Thibaut, Frank J. M. van Kuppeveld
Bypassing pan-enterovirus host factor PLA2G16
published pages: 3171, ISSN: 2041-1723, DOI: 10.1038/s41467-019-11256-z
Nature Communications 10/1 2019-10-03
2019 Natacha S. Ogando, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C. Posthuma, Eric J. Snijder
The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.01813
Frontiers in Microbiology 10 2019-10-03
2018 Mike Bray, Graciela Andrei, Ester Ballana, Kara Carter, David Durantel, Brian Gentry, Zlatko Janeba, Jennifer Moffat, Clasien J. Oomen, Bart Tarbet, Eva Riveira-Muñoz, José. A. Esté
Meeting report: 31st International Conference on Antiviral Research
published pages: 88-102, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.08.002
Antiviral Research 158 2019-10-03
2019 Ana S. Ferreira-Ramos, Changqing Li, Cécilia Eydoux, Jean Marie Contreras, Christophe Morice, Gilles Quérat, Alba Gigante, María-Jesús Pérez Pérez, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly, Bruno Coutard
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay
published pages: 59-69, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2019.01.003
Antiviral Research 163 2019-10-03
2019 Lisa Bauer, Roberto Manganaro, Birgit Zonsics, Jeroen R. P. M. Strating, Priscila El Kazzi, Moira Lorenzo Lopez, Rachel Ulferts, Clara van Hoey, Maria J. Maté, Thierry Langer, Bruno Coutard, Andrea Brancale, Frank J. M. van Kuppeveld
Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner
published pages: 1609-1623, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.9b00179
ACS Infectious Diseases 5/9 2019-10-03
2019 Ji-seong Yoon, Gyudong Kim, Dnyandev B. Jarhad, Hong-Rae Kim, Young-Sup Shin, Shuhao Qu, Pramod K. Sahu, Hea Ok Kim, Hyuk Woo Lee, Su Bin Wang, Yun Jeong Kong, Tong-Shin Chang, Natacha S. Ogando, Kristina Kovacikova, Eric J. Snijder, Clara C. Posthuma, Martijn J. van Hemert, Lak Shin Jeong
Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues
published pages: 6346-6362, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00781
Journal of Medicinal Chemistry 62/13 2019-10-03
2018 Pietro Scaturro, Alexey Stukalov, Darya A. Haas, Mirko Cortese, Kalina Draganova, Anna Płaszczyca, Ralf Bartenschlager, Magdalena Götz, Andreas Pichlmair
An orthogonal proteomic survey uncovers novel Zika virus host factors
published pages: 253-257, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0484-5
Nature 561/7722 2019-09-20
2019 Heyrhyoung Lyoo, Hilde M. van der Schaar, Cristina M. Dorobantu, Huib H. Rabouw, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld
ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB
published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.02742-18
mBio 10/1 2019-09-20
2019 Anna PÅ‚aszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager
A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle
published pages: e1007736, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007736
PLOS Pathogens 15/5 2019-09-20
2018 C. E. Melia, H. M. van der Schaar, A. W. M. de Jong, H. R. Lyoo, E. J. Snijder, A. J. Koster, F. J. M. van Kuppeveld, M. Bárcena
The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles
published pages: e00420-18, ISSN: 2150-7511, DOI: 10.1128/mbio.00420-18
mBio 9/2 2019-08-06
2018 Lanko, Kristina; Ma, Yipeng; Delang, Leen; Mirabelli, Carmen; Neyts, Johan
Antiviral effects of selected nucleoside analogs against human parechoviruses A1 and A3
published pages: , ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.009
Lirias 1 2019-08-06
2018 Angelica Corcuera, Katharina Stolle, Stefan Hillmer, Stefan Seitz, Ji-Young Lee, Ralf Bartenschlager, Alexander Birkmann, Andreas Urban
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro
published pages: 135-142, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.07.011
Antiviral Research 158 2019-05-22
2018 Lisa Bauer, Salvatore Ferla, Sarah A. Head, Shridhar Bhat, Kalyan K. Pasunooti, Wei Q. Shi, Lucian Albulescu, Jun O. Liu, Andrea Brancale, Frank J.M. van Kuppeveld, Jeroen R.P.M. Strating
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)
published pages: 55-63, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.05.010
Antiviral Research 156 2019-05-22
2018 Maximilian Münster, Anna Płaszczyca, Mirko Cortese, Christopher Neufeldt, Sarah Goellner, Gang Long, Ralf Bartenschlager
A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy
published pages: 368, ISSN: 1999-4915, DOI: 10.3390/v10070368
Viruses 10/7 2019-05-22

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