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eCHO Systems

Enhancing CHO by Mammalian Systems Biotechnology (eCHO systems)

Total Cost €

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EC-Contrib. €

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Partnership

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Project "eCHO Systems" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.echo-systems.eu
 Total cost 4˙044˙794 €
 EC max contribution 4˙044˙793 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙160˙327.00
2    ACIB GMBH AT (GRAZ) participant 1˙017˙018.00
3    UNIVERSITY OF KENT UK (CANTERBURY, KENT) participant 819˙863.00
4    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 797˙023.00
5    UCB PHARMA SA BE (BRUXELLES) participant 250˙560.00
6    RENTSCHLER BIOTECHNOLOGIE GMBH DE (LAUPHEIM) participant 0.00
7    BIONEER A/S DK (HOERSHOLM) partner 0.00
8    BOEHRINGER INGELHEIM PHARMA GMBH &CO KG DE (INGELHEIM) partner 0.00
9    Chorus GmbH AT (BOHEIMKIRCHEN) partner 0.00
10    CMC BIOLOGICS AS DK (SOBORG) partner 0.00
11    Eli Lilly and Company Limited UK (Basingstoke) partner 0.00
12    EVERCYTE GMBH AT (WIEN) partner 0.00
13    FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED UK (BILLINGHAM) partner 0.00
14    ICOSAGEN AS EE (TARTU) partner 0.00
15    Janssen Biologics NL (Leiden) partner 0.00
16    Symphogen A/S DK (Lyngby) partner 0.00
17    UNIVERSITAET FUER BODENKULTUR WIEN AT (WIEN) partner 0.00

Map

 Project objective

Chinese hamster (CHO) ovary cells are the production host for a 50 billion €/yr biopharmaceuticals market. Current CHO production platforms dates to 1980 and are based primarily on media and process optimisation with little consideration to the optimization of the cellular machinery. Fortunately, with the recent sequencing of the CHO genome, an opportunity has opened to significantly advance the CHO platform. The benefit will be advanced production flexibility and a lower production cost.

This ITN graduate training programme - eCHO Systems - will blend conventional molecular, cellular, and synthetic biology with genome scale systems biology training in ‘omics data acquisition, biological network modeling, and genome engineering in three interdisciplinary topics:

1) Acquisition of large scale ‘omics data sets and their incorporation into genome-scale mathematical models 2) Development of genome engineering tools, enabling synthetic biology 3) Application of systems and synthetic biology and genome engineering to improve performance of CHO producers

The training projects are supported by 15 industrial participants, which will participate in the research and test the results. ESR training will include intense courses focused on computational systems biology, cell biology, business and entrepreneurship. The three universities bring unique complementary skills in systems and synthetic biology, ‘omics technologies, cytometry, and molecular cell biology which will provide depth and breadth to this training. The eCHO Systems will produce four major outputs: General knowledge to improve the productivity, quality, and efficiency of CHO platform cell lines, new systems models for CHO cells, new CHO cell line chassises generated through synthetic biology approaches, high quality education at the graduate level, and a cadre of interdisciplinary graduates poised to transform biopharmaceutical biotechnology.

 Deliverables

List of deliverables.
Integration of proteomic and post-translational data Documents, reports 2019-09-06 08:37:52
Omics-datasets distributed Documents, reports 2019-09-06 08:37:52
Publications Documents, reports 2019-09-06 08:37:52
High throughput screens for gene function and engineered CHO chassis designed for improved recombinant protein yields Documents, reports 2019-09-06 08:37:52
Transcriptional and genomic cross-effects Documents, reports 2019-09-06 08:37:52
Training complete Other 2019-09-06 08:37:52
Effects of lncRNAs Documents, reports 2019-09-06 08:37:52
Final Report Documents, reports 2019-09-06 08:37:52
Enhancing translational rates and protein synthesis Documents, reports 2019-09-06 08:37:52
Mid Term review meeting Documents, reports 2019-09-06 08:37:52
Appointment of SAB Other 2019-09-06 08:37:51

Take a look to the deliverables list in detail:  detailed list of eCHO Systems deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Heena Dhiman, Matthias P. Gerstl, David Ruckerbauer, Michael Hanscho, Heinz Himmelbauer, Colin Clarke, Niall Barron, Jürgen Zanghellini, Nicole Borth
Genetic and epigenetic variation across genes involved in energy metabolism and mitochondria of Chinese Hamster Ovary cell lines
published pages: 1800681, ISSN: 1860-6768, DOI: 10.1002/biot.201800681
Biotechnology Journal 2019-09-06
2017 Henning Gram Hansen, Nuša Pristovšek, Helene Faustrup Kildegaard, Gyun Min Lee
Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
published pages: 64-76, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2016.11.008
Biotechnology Advances 35/1 2019-09-06
2018 Linas Tamošaitis, Christopher Mark Smales
Meta-Analysis of Publicly Available Chinese Hamster Ovary (CHO) Cell Transcriptomic Datasets for Identifying Engineering Targets to Enhance Recombinant Protein Yields
published pages: 1800066, ISSN: 1860-6768, DOI: 10.1002/biot.201800066
Biotechnology Journal 2019-09-06
2018 Prashant Kaushik, Michael Henry, Martin Clynes, Paula Meleady
The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture
published pages: 1700221, ISSN: 1860-6768, DOI: 10.1002/biot.201700221
Biotechnology Journal 13/10 2019-09-06
2018 Nina Bydlinski, Daniel Maresch, Valerie Schmieder, Gerald Klanert, Richard Strasser, Nicole Borth
The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells
published pages: 101-110, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.07.015
Journal of Biotechnology 282 2019-09-06
2019 Cyrielle Calmels, Andréa McCann, Laetitia Malphettes, Mikael Rørdam Andersen
Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process
published pages: 9-19, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.09.009
Metabolic Engineering 51 2019-09-06
2018 Davide Vito, C Mark Smales
Engineering of the cellular translational machinery and non-coding RNAs to enhance CHO cell growth, recombinant product yields and quality
published pages: 199-208, ISSN: 2211-3398, DOI: 10.1016/j.coche.2018.11.002
Current Opinion in Chemical Engineering 22 2019-09-06
2017 Michael Henry, Martin Power, Prashant Kaushik, Orla Coleman, Martin Clynes, Paula Meleady
Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift
published pages: 2339-2358, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.6b00868
Journal of Proteome Research 16/7 2019-09-06
2019 Thomas Amann, Anders Holmgaard Hansen, Stefan Kol, Henning Gram Hansen, Johnny Arnsdorf, Saranya Nallapareddy, Bjørn Voldborg, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles
published pages: 143-152, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.11.014
Metabolic Engineering 52 2019-09-06
2019 Inmaculada Hernandez, Heena Dhiman, Gerald Klanert, Vaibhav Jadhav, Norbert Auer, Michael Hanscho, Martina Baumann, Anna Esteve-Codina, Marc Dabad, Jessica Gómez, Tyler Alioto, Angelika Merkel, Emanuele Raineri, Simon Heath, Daniel Rico, Nicole Borth
Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture
published pages: 677-692, ISSN: 0006-3592, DOI: 10.1002/bit.26891
Biotechnology and Bioengineering 116/3 2019-09-06
2017 Paul S. Kelly, Colin Clarke, Alan Costello, Craig Monger, Justine Meiller, Heena Dhiman, Nicole Borth, Michael J. Betenbaugh, Martin Clynes, Niall Barron
Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells
published pages: , ISSN: 1096-7176, DOI: 10.1016/j.ymben.2017.02.001
Metabolic Engineering 2019-09-06
2017 Amandine Bastide, Diego Peretti, John R.P. Knight, Stefano Grosso, Ruth V. Spriggs, Xavier Pichon, Thomas Sbarrato, Anne Roobol, Jo Roobol, Davide Vito, Martin Bushell, Tobias von der Haar, C. Mark Smales, Giovanna R. Mallucci, Anne E. Willis
RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3
published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.01.047
Current Biology 2019-09-06
2018 Thomas Amann, Anders Holmgaard Hansen, Stefan Kol, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 tailors N-glycan profiles of therapeutics and secreted host cell proteins
published pages: 1800111, ISSN: 1860-6768, DOI: 10.1002/biot.201800111
Biotechnology Journal 2019-09-06
2018 Sara Pereira, Helene Faustrup Kildegaard, Mikael Rørdam Andersen
Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients
published pages: 1700499, ISSN: 1860-6768, DOI: 10.1002/biot.201700499
Biotechnology Journal 13/3 2019-09-06
2018 Valerie Schmieder, Nina Bydlinski, Richard Strasser, Martina Baumann, Helene Faustrup Kildegaard, Vaibhav Jadhav, Nicole Borth
Enhanced Genome Editing Tools For Multi-Gene Deletion Knock-Out Approaches Using Paired CRISPR sgRNAs in CHO Cells
published pages: 1700211, ISSN: 1860-6768, DOI: 10.1002/biot.201700211
Biotechnology Journal 13/3 2019-09-06
2018 Nuša Pristovšek, Henning Gram Hansen, Daria Sergeeva, Nicole Borth, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept
published pages: 1700216, ISSN: 1860-6768, DOI: 10.1002/biot.201700216
Biotechnology Journal 13/3 2019-09-06
2018 Oliver Rupp, Madolyn L. MacDonald, Shangzhong Li, Heena Dhiman, Shawn Polson, Sven Griep, Kelley Heffner, Inmaculada Hernandez, Karina Brinkrolf, Vaibhav Jadhav, Mojtaba Samoudi, Haiping Hao, Brewster Kingham, Alexander Goesmann, Michael J. Betenbaugh, Nathan E. Lewis, Nicole Borth, Kelvin H. Lee
A reference genome of the Chinese hamster based on a hybrid assembly strategy
published pages: , ISSN: 0006-3592, DOI: 10.1002/bit.26722
Biotechnology and Bioengineering 2019-09-06
2018 Ricardo Valdés-Bango Curell, Niall Barron
Exploring the Potential Application of Short Non-Coding RNA-Based Genetic Circuits in Chinese Hamster Ovary Cells
published pages: 1700220, ISSN: 1860-6768, DOI: 10.1002/biot.201700220
Biotechnology Journal 2019-09-06
2018 Davide Vito, Christopher Mark Smales
The Long Non-Coding RNA Transcriptome Landscape in CHO Cells Under Batch and Fed-Batch Conditions
published pages: 1800122, ISSN: 1860-6768, DOI: 10.1002/biot.201800122
Biotechnology Journal 2019-09-06
2018 Ankita Singh, Helene F. Kildegaard, Mikael R. Andersen
An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures
published pages: 1800070, ISSN: 1860-6768, DOI: 10.1002/biot.201800070
Biotechnology Journal 2019-09-06
2018 Nicolas Marx, Clemens Grünwald-Gruber, Nina Bydlinski, Heena Dhiman, Ly Ngoc Nguyen, Gerald Klanert, Nicole Borth
CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells
published pages: 1700217, ISSN: 1860-6768, DOI: 10.1002/biot.201700217
Biotechnology Journal 2019-09-06

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