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Brain circRNAs

Rounding the circle: Unravelling the biogenesis, function and mechanism of action of circRNAs in the Drosophila brain.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Brain circRNAs" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙971˙750 €
 EC max contribution 1˙971˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙971˙750.00

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 Project objective

Tight regulation of RNA metabolism is essential for normal brain function. This includes co and post-transcriptional regulation, which are extremely prevalent in neurons. Recently, circular RNAs (circRNAs), a highly abundant new type of regulatory non-coding RNA have been found across the animal kingdom. Two of these RNAs have been shown to act as miRNA sponges but no function is known for the thousands of other circRNAs, indicating the existence of a widespread layer of previously unknown gene regulation. The present proposal aims to comprehensively determine the role and mode of actions of circRNAs in gene expression and RNA metabolism in the fly brain. We will do so by studying their biogenesis, transport, and mechanism of action, as well as by determining the roles of circRNAs in neuronal function and behaviour. Briefly, we will: 1) identify factors involved in the biogenesis, localization, and stabilization of circRNAs; 2) determine neuro-developmental, molecular, neural and behavioural phenotypes associated with down or up regulation of specific circRNAs; 3) study the molecular mechanisms of action of circRNAs: identify circRNAs that work as miRNA sponges and determine whether circRNAs can encode proteins or act as signalling molecules and 4) perform mechanistic studies in order to determine cause-effect relationships between circRNA function and brain physiology and behaviour. The present proposal will reveal the key pathways by which circRNAs control gene expression and influence neuronal function and behaviour. Therefore it will be one of the pioneer works in the study of this new and important area of research, which we predict will fundamentally transform the study of gene expression regulation in the brain

 Publications

year authors and title journal last update
List of publications.
2017 Ilana Buchumenski, Osnat Bartok, Reut Ashwal-Fluss, Varun Pandey, Hagit T. Porath, Erez Y. Levanon, Sebastian Kadener
Dynamic hyper-editing underlies temperature adaptation in Drosophila
published pages: e1006931, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006931
PLOS Genetics 13/7 2019-07-22
2016 Vaibhav Chikne, Tirza Doniger, K. Shanmugha Rajan, Osnat Bartok, Dror Eliaz, Smadar Cohen-Chalamish, Christian Tschudi, Ron Unger, Yaser Hashem, Sebastian Kadener, Shulamit Michaeli
A pseudouridylation switch in rRNA is implicated in ribosome function during the life cycle of Trypanosoma brucei
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep25296
Scientific Reports 6/1 2019-07-22
2017 Shaked Afik, Osnat Bartok, Maxim N. Artyomov, Alexander A. Shishkin, Sabah Kadri, Mor Hanan, Xiaopeng Zhu, Manuel Garber, Sebastian Kadener
Defining the 5΄ and 3΄ landscape of the Drosophila transcriptome with Exo-seq and RNaseH-seq
published pages: e95-e95, ISSN: 0305-1048, DOI: 10.1093/nar/gkx133
Nucleic Acids Research 45/11 2019-07-22

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The information about "BRAIN CIRCRNAS" are provided by the European Opendata Portal: CORDIS opendata.

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